Substrate: PML (protein binding)
Seq-ID: P29590 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-4793330   MDM2_HUMAN
MINT-4793489   P53_HUMAN
MINT-6743913   TOP3A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
DNA binding,
protein homodimerization activity,
ubiquitin protein ligase binding,
transcription coactivator activity,
zinc ion binding,
protein binding,
transcription repressor activity,
cobalt ion binding		 cytoplasm,
nuclear membrane,
nucleolus,
nuclear matrix,
insoluble fraction,
nucleus,
PML body		 protein stabilization,
negative regulation of angiogenesis,
negative regulation of cell proliferation,
negative regulation of cell growth,
cell cycle arrest,
positive regulation of histone deacetylation,
negative regulation of transcription,
PML body organization,
response to cytokine stimulus,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
protein targeting,
maintenance of protein location in nucleus,
negative regulation of mitotic cell cycle,
induction of apoptosis,
DNA damage response, signal transduction resulting in induction of apoptosis,
negative regulation of translation in response to oxidative stress,
positive regulation of defense response to virus by host,
protein complex assembly,
transcription,
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,
response to hypoxia
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 518 QPRPSTSKAVSPPHLDGPPSP - 18669648
HTP
1.00
 - -
0.95
 - medium

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