Substrate: Presenilin 1 (Presenilin 1 (PS-1) (S182 protein))
Seq-ID: P49769 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-1958847   EFNB1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cadherin binding,
endopeptidase activity		 neuronal cell body,
cytoplasmic vesicle,
dendritic shaft,
endoplasmic reticulum membrane,
growth cone,
Golgi membrane,
ciliary rootlet,
integral to plasma membrane,
cell surface,
axon		 beta-amyloid metabolic process,
Cajal-Retzius cell differentiation,
negative regulation of axonogenesis,
smooth endoplasmic reticulum calcium ion homeostasis,
cerebral cortex cell migration,
skeletal system morphogenesis,
neuron development,
response to oxidative stress,
brain morphogenesis,
Notch receptor processing,
mitochondrial transport,
regulation of synaptic plasticity,
positive regulation of apoptosis,
post-embryonic development,
anagen,
heart looping,
amyloid precursor protein catabolic process,
synaptic vesicle targeting,
positive regulation of coagulation,
cell fate specification,
memory,
T cell receptor signaling pathway,
embryonic limb morphogenesis,
positive regulation of MAP kinase activity,
positive regulation of protein amino acid phosphorylation,
choline transport,
blood vessel development,
membrane protein ectodomain proteolysis,
dorsal/ventral neural tube patterning,
regulation of synaptic transmission, glutamatergic,
thymus development,
anti-apoptosis,
protein amino acid glycosylation,
protein transport,
regulation of epidermal growth factor receptor activity,
T cell activation involved in immune response,
hemopoietic progenitor cell differentiation,
regulation of resting membrane potential,
L-glutamate transport,
Notch signaling pathway,
neuron migration,
neuron apoptosis,
autophagic vacuole assembly,
response to DNA damage stimulus,
myeloid leukocyte differentiation,
epithelial cell proliferation,
negative regulation of protein kinase activity,
regulation of protein binding,
protein maturation by peptide bond cleavage,
somitogenesis,
activation of MAPKK activity,
negative regulation of protein amino acid phosphorylation
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 329 RAERETQDSGSGNDDGGFSEE - 19144319
HTP
0.78
 - PSN
0.75
 - medium
S 365 PESRAAVQELSGSILTSEDPE - 19144319
HTP
0.16
 - PSN
0.52
 - medium
S 367 SRAAVQELSGSILTSEDPEER - 15345747
HTP
0.58
 - PSN
0.49
 - medium
S 367 SRAAVQELSGSILTSEDPEER - 17242355
HTP
0.58
 - PSN
0.49
 - medium
S 367 SRAAVQELSGSILTSEDPEER - 19144319
HTP
0.58
 - PSN
0.49
 - medium
T 370 AVQELSGSILTSEDPEERGVK - 15345747
HTP
0.16
 - PSN
0.43
 - medium
T 370 AVQELSGSILTSEDPEERGVK - 17242355
HTP
0.16
 - PSN
0.43
 - medium
T 370 AVQELSGSILTSEDPEERGVK - 19144319
HTP
0.16
 - PSN
0.43
 - medium
S 371 VQELSGSILTSEDPEERGVKL - 17242355
HTP
0.55
 - PSN
0.41
 - medium
S 371 VQELSGSILTSEDPEERGVKL - 19144319
HTP
0.55
 - PSN
0.41
 - medium

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