| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|
| similar to Centromeric protein E (CENP-E protein) |
unclassified |
|
|
|
| DNA topoisomerase II, alpha |
DNA topoisomerase II alpha |
protein kinase C binding,
DNA topoisomerase (ATP-hydrolyzing) activity,
DNA-dependent ATPase activity,
chromatin binding,
histone deacetylase binding,
ATP binding,
ubiquitin binding,
drug binding,
protein heterodimerization activity,
protein C-terminus binding,
protein homodimerization activity,
protein binding |
DNA topoisomerase complex (ATP-hydrolyzing),
cytoplasm,
condensed chromosome,
chromosome,
nucleolus,
nucleoplasm |
positive regulation of apoptosis,
DNA ligation,
DNA replication,
chromosome condensation,
DNA repair,
embryonic cleavage,
chromosome segregation,
phosphoinositide-mediated signaling,
apoptotic chromosome condensation,
DNA topological change,
positive regulation of transcription from RNA polymerase II promoter,
positive regulation of retroviral genome replication |
| MER |
Receptor tyrosine kinase |
ATP binding,
transmembrane receptor protein tyrosine kinase activity,
protein binding |
soluble fraction,
integral to plasma membrane |
visual perception,
cell-cell signaling,
response to stimulus,
protein amino acid phosphorylation,
cell surface receptor linked signaling pathway |
| DNA topoisomerase II |
DNA topoisomerase II (EC 5.99.1.3) (from PhosphoBase) |
DNA topoisomerase (ATP-hydrolyzing) activity,
mRNA binding,
rDNA binding,
ATP binding,
satellite DNA binding,
four-way junction DNA binding,
protein binding |
synaptonemal complex,
cytoplasm,
insoluble fraction,
soluble fraction,
chromatin accessibility complex,
mitochondrion,
chromosome |
reciprocal meiotic recombination,
chromatin silencing,
chromatin remodeling at centromere,
chromatin assembly or disassembly,
meiosis,
DNA strand elongation involved in DNA replication,
regulation of mitotic recombination,
mitotic spindle organization,
DNA topological change,
mitotic chromosome condensation,
mitotic cell cycle G2/M transition decatenation checkpoint,
metaphase plate congression |
| DNA polymerase beta |
DNA polymerase beta (from PhosphoBase) |
DNA-directed DNA polymerase activity,
metal ion binding,
damaged DNA binding,
lyase activity |
nucleus |
pyrimidine dimer repair,
DNA replication,
response to ethanol |
| G6P isomerase |
Glucose-6-phosphate isomerase |
cytokine activity,
growth factor activity,
glucose-6-phosphate isomerase activity |
cytoplasm,
extracellular space |
gluconeogenesis,
hemostasis,
glycolysis,
angiogenesis,
humoral immune response |
| Telomeric repeat binding factor 1 |
Telomeric repeat binding factor 1 (TTAGGG repeat binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1) |
DNA bending activity,
telomeric DNA binding,
caspase activator activity,
double-stranded telomeric DNA binding,
protein heterodimerization activity,
protein homodimerization activity,
telomerase inhibitor activity,
microtubule binding |
spindle,
nuclear telomere cap complex,
cytoplasm,
chromosome, telomeric region,
nucleoplasm,
nucleus |
positive regulation of mitotic cell cycle,
activation of caspase activity,
regulation of transcription,
telomere maintenance via telomerase,
telomere maintenance via telomere shortening,
negative regulation of telomere maintenance via telomerase,
mitosis,
protein homooligomerization,
induction of apoptosis,
negative regulation of telomerase activity,
negative regulation of telomere maintenance via semi-conservative replication,
cell division,
positive regulation of microtubule polymerization,
positive regulation of mitosis,
mitotic cell cycle spindle assembly checkpoint,
age-dependent telomere shortening,
G2/M transition of mitotic cell cycle |
| Telomerase reverse transcriptase |
Telomerase reverse transcriptase |
telomeric RNA binding,
telomeric DNA binding,
telomeric template RNA reverse transcriptase activity,
protein homodimerization activity |
nuclear telomere cap complex,
cytoplasm,
telomerase holoenzyme complex,
nucleolus,
nucleoplasm |
senescence,
telomere maintenance via telomerase,
DNA strand elongation,
anti-apoptosis,
telomere formation via telomerase |
| Centromeric protein a |
DNA binding protein |
DNA binding,
chromatin binding,
protein binding |
condensed nuclear chromosome kinetochore,
nucleosome |
kinetochore assembly,
interspecies interaction between organisms,
nucleosome assembly,
establishment of mitotic spindle orientation,
protein localization to chromosome, centromeric region |
| Centromeric protein E |
DNA binding protein |
kinetochore binding,
ATP binding,
microtubule motor activity |
spindle,
condensed chromosome kinetochore,
cytoplasm,
microtubule,
nucleus |
positive regulation of protein kinase activity,
kinetochore assembly,
microtubule-based movement,
mitotic metaphase plate congression,
cell division,
mitotic metaphase,
mitotic chromosome movement towards spindle pole,
multicellular organismal development |
| Inner centromere protein |
Cell cycle control protein |
protein binding |
spindle,
condensed chromosome kinetochore,
cytoplasm,
centromeric heterochromatin,
microtubule,
central element,
midbody |
cytokinesis,
mitosis,
chromosome segregation |
| RNA polymerase II subunit A C-terminal domain phosphatase |
Enzyme: Phosphohydrolase |
DNA-directed RNA polymerase activity,
CTD phosphatase activity |
nucleoplasm |
protein amino acid dephosphorylation |
| Octamer binding transcription factor 1 |
Transcription factor |
transcription repressor activity,
sequence-specific DNA binding,
sequence-specific DNA binding transcription factor activity,
protein binding |
|
transcription,
negative regulation of transcription, DNA-dependent |
| Coatomer protein complex, subunit alpha |
Transport/cargo protein |
hormone activity,
calcium ion binding,
unfolded protein binding,
structural molecule activity |
COPI vesicle coat,
microsome,
cytosol,
soluble fraction,
endoplasmic reticulum,
extracellular space |
intracellular protein transport,
pancreatic juice secretion,
retrograde vesicle-mediated transport, Golgi to ER,
protein folding,
COPI coating of Golgi vesicle |
| DNA topoisomerase II, beta |
Enzyme: Topoisomerase |
protein kinase C binding,
DNA topoisomerase (ATP-hydrolyzing) activity,
chromatin binding,
histone deacetylase binding,
ATP binding,
protein heterodimerization activity,
protein C-terminus binding |
SWI/SNF-type complex,
cytosol,
chromosome,
nucleolus,
nucleoplasm |
axonogenesis,
forebrain development,
neuron migration,
DNA topological change |
| DNA polymerase alpha 70 kDa subunit |
DNA polymerase |
DNA binding,
protein heterodimerization activity |
alpha DNA polymerase:primase complex,
nucleoplasm |
DNA replication,
protein import into nucleus, translocation |
| Protein disulfide isomerase P5 |
Enzyme: Isomerase |
protein disulfide isomerase activity,
protein binding |
plasma membrane,
ER-Golgi intermediate compartment,
melanosome,
endoplasmic reticulum lumen |
protein folding,
cell redox homeostasis |
| Telomeric repeat binding factor 2 |
DNA binding protein |
double-stranded telomeric DNA binding,
protein C-terminus binding,
protein homodimerization activity |
nuclear telomere cap complex,
male germ cell nucleus,
Mre11 complex,
nucleoplasm,
nuclear chromosome, telomeric region |
senescence,
regulation of transcription,
protection from non-homologous end joining at telomere,
telomere maintenance via telomerase,
telomeric loop formation,
negative regulation of telomere maintenance via semi-conservative replication,
protein localization to chromosome, telomeric region,
cell cycle,
in utero embryonic development,
positive regulation of telomere maintenance,
age-dependent telomere shortening |
| Telomeric repeat binding factor 2 interacting protein 1 |
Cell cycle control protein |
DNA binding,
protein binding |
nuclear telomere cap complex,
cytoplasm,
Mre11 complex,
nucleoplasm |
telomere maintenance via telomere lengthening,
protection from non-homologous end joining at telomere,
telomere maintenance via telomerase,
negative regulation of DNA recombination at telomere,
regulation of double-strand break repair via homologous recombination,
protein localization to chromosome, telomeric region,
transcription,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
negative regulation of telomere maintenance,
positive regulation of NF-kappaB transcription factor activity |
| Emerin |
1 trans15 protein |
actin binding,
beta-tubulin binding |
nuclear inner membrane,
integral to membrane,
microtubule,
endoplasmic reticulum,
nuclear lamina,
nuclear outer membrane |
negative regulation of fibroblast proliferation,
positive regulation of protein export from nucleus,
muscle contraction,
regulation of canonical Wnt receptor signaling pathway,
negative regulation of catenin protein nuclear translocation,
muscle organ development,
cellular response to growth factor stimulus |
| Telomerase-binding protein p23 |
Chaperone |
prostaglandin-E synthase activity,
telomerase activity,
unfolded protein binding |
cytoplasm,
chromosome, telomeric region,
cytosol,
telomerase holoenzyme complex |
telomere maintenance,
chaperone cofactor-dependent protein refolding,
prostaglandin biosynthetic process,
signal transduction |
| DNA-directed RNA polymerase I 40 kDa polypeptide |
DNA-dependent RNA polymerase |
protein dimerization activity,
DNA-directed RNA polymerase activity,
DNA binding |
DNA-directed RNA polymerase I complex,
nucleoplasm |
transcription from RNA polymerase I promoter |
| Merlin |
Probably acts as a ,15, stabilizing protein |
cytoskeletal protein binding |
cytoskeleton,
perinuclear region of cytoplasm,
early endosome,
nucleolus,
ruffle membrane,
extrinsic to membrane,
filopodium membrane |
actin cytoskeleton organization,
negative regulation of tyrosine phosphorylation of Stat5 protein,
positive regulation of stress fiber assembly,
negative regulation of cell proliferation,
regulation of hippo signaling cascade,
negative regulation of cell-matrix adhesion,
Schwann cell proliferation,
negative regulation of cell migration,
negative regulation of tyrosine phosphorylation of Stat3 protein,
negative regulation of DNA replication,
negative regulation of cell-cell adhesion |
| Polymerase I and transcript release factor |
Termination of transcription by RNA polymerase I |
rRNA primary transcript binding,
RNA polymerase I transcription termination factor activity,
protein binding |
microsome,
caveola,
cytosol,
endoplasmic reticulum,
mitochondrion,
nucleoplasm,
nucleus |
transcription termination,
transcription initiation from RNA polymerase I promoter |
| Protein disulfide-isomerase A3 precursor |
Protein disulfide isomerase family |
protein disulfide isomerase activity |
melanosome,
endoplasmic reticulum lumen |
cell redox homeostasis |
| Tubulin polymerization-promoting protein |
Promotes in vitro the polymerization of tubulin into double-walled tubules |
microtubule binding |
soluble fraction,
perinuclear region of cytoplasm,
microtubule,
nucleus |
positive regulation of protein polymerization,
microtubule polymerization,
microtubule bundle formation |
| Homer3 |
Unclassified |
protein C-terminus binding,
protein domain specific binding |
cell junction,
cytoplasm,
postsynaptic membrane,
postsynaptic density |
protein targeting,
metabotropic glutamate receptor signaling pathway |
| Coatomer beta subunit |
unclassified |
structural molecule activity,
protein binding |
COPI vesicle coat,
cytosol |
intracellular protein transport,
intra-Golgi vesicle-mediated transport,
retrograde vesicle-mediated transport, Golgi to ER,
COPI coating of Golgi vesicle |
| Centromere protein N |
unclassified |
|
condensed chromosome kinetochore,
nucleus |
|
| DNA polymerase delta subunit 3 |
DNA binding |
DNA-directed DNA polymerase activity,
protein binding |
delta DNA polymerase complex,
nucleoplasm |
mismatch repair,
nucleotide-excision repair, DNA gap filling,
DNA synthesis involved in DNA repair |
| DNA polymerase epsilon subunit 3 |
DNA binding |
DNA-directed DNA polymerase activity,
sequence-specific DNA binding,
protein binding |
nucleus |
DNA replication |
| Mediator of RNA polymerase II transcription subunit 12 |
receptor activity |
ligand-dependent nuclear receptor transcription coactivator activity,
RNA polymerase II transcription mediator activity,
receptor activity,
protein C-terminus binding,
protein domain specific binding,
vitamin D receptor binding,
thyroid hormone receptor binding |
mediator complex,
centrosome,
nucleolus |
negative regulation of Wnt receptor signaling pathway,
androgen receptor signaling pathway,
transcription initiation from RNA polymerase II promoter,
positive regulation of transcription from RNA polymerase II promoter |
| Non-POU domain-containing octamer-binding protein |
protein binding |
DNA binding,
identical protein binding,
RNA binding,
nucleotide binding |
paraspeckles,
nuclear matrix |
regulation of transcription,
DNA recombination,
mRNA processing,
transcription,
DNA repair,
RNA splicing |
| Repressor of RNA polymerase III transcription MAF1 homolog |
unclassified |
transcription regulator activity |
nucleus |
negative regulation of transcription from RNA polymerase III promoter,
transcription |
| Triosephosphate isomerase |
triose-phosphate isomerase activity |
triose-phosphate isomerase activity |
|
gluconeogenesis,
fatty acid biosynthetic process,
pentose-phosphate shunt,
glycolysis |
| Poly [ADP-ribose] polymerase 1 |
|
NAD+ ADP-ribosyltransferase activity,
DNA binding,
identical protein binding,
protein N-terminus binding,
transcription factor binding,
zinc ion binding |
transcription factor complex,
nucleolus,
nuclear envelope |
regulation of transcription,
cellular response to insulin stimulus,
transcription from RNA polymerase II promoter,
protein amino acid ADP-ribosylation |
| DNA-directed RNA polymerase II subunit RPB9 |
|
DNA-directed RNA polymerase activity,
DNA binding,
transcription regulator activity,
zinc ion binding |
DNA-directed RNA polymerase II, core complex |
transcription initiation from RNA polymerase II promoter,
RNA elongation from RNA polymerase II promoter,
RNA splicing |
| RNA polymerase II elongation factor ELL |
|
RNA polymerase II transcription elongation factor activity,
positive transcription elongation factor activity,
protein binding |
Cajal body,
transcription elongation factor complex,
nuclear speck |
RNA elongation from RNA polymerase II promoter |
| Coatomer subunit zeta-1 |
|
protein binding |
COPI vesicle coat,
cytosol |
intracellular protein transport,
intra-Golgi vesicle-mediated transport,
retrograde vesicle-mediated transport, Golgi to ER,
COPI coating of Golgi vesicle |
| DNA polymerase epsilon catalytic subunit A |
|
DNA binding,
DNA-directed DNA polymerase activity,
chromatin binding,
nucleotide binding,
zinc ion binding,
protein binding |
nucleoplasm |
G1/S transition of mitotic cell cycle,
nucleotide-excision repair, DNA gap filling,
DNA synthesis involved in DNA repair |
| TATA box-binding protein-associated factor RNA polymerase I subunit C |
|
DNA binding,
general RNA polymerase II transcription factor activity,
RNA polymerase I transcription factor activity |
nucleoplasm |
transcription from RNA polymerase I promoter,
transcription from RNA polymerase II promoter |
| Mediator of RNA polymerase II transcription subunit 13-like |
|
|
|
regulation of transcription,
transcription |
| Poly [ADP-ribose] polymerase 8 |
|
NAD+ ADP-ribosyltransferase activity |
intracellular |
|
| DNA polymerase epsilon subunit 4 |
|
DNA-directed DNA polymerase activity,
sequence-specific DNA binding,
protein binding |
nucleus |
|
| Mediator of RNA polymerase II transcription subunit 17 |
|
ligand-dependent nuclear receptor transcription coactivator activity,
RNA polymerase II transcription mediator activity,
receptor activity,
vitamin D receptor binding,
thyroid hormone receptor binding |
transcription factor complex,
mediator complex |
androgen receptor signaling pathway,
transcription initiation from RNA polymerase II promoter,
positive regulation of transcription from RNA polymerase II promoter |
| DNA-directed RNA polymerase III subunit RPC5 |
|
DNA-directed RNA polymerase activity |
nucleus |
transcription,
innate immune response,
response to virus |
| DNA-directed RNA polymerase III subunit RPC2 |
|
DNA-directed RNA polymerase activity,
DNA binding,
metal ion binding,
ribonucleoside binding |
nucleus |
positive regulation of interferon-beta production,
transcription,
innate immune response,
positive regulation of innate immune response,
response to virus |
| DNA polymerase lambda |
|
DNA binding,
DNA-directed DNA polymerase activity,
metal ion binding,
lyase activity |
nucleus |
DNA replication,
somatic hypermutation of immunoglobulin genes,
nucleotide-excision repair |
| TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L |
|
DNA binding,
RNA polymerase II transcription factor activity,
transcription coactivator activity,
transcription initiation factor activity |
histone deacetylase complex,
STAGA complex |
regulation of transcription factor activity,
chromatin remodeling,
transcription initiation,
regulation of transcription from RNA polymerase II promoter,
histone H3 acetylation |
| Conserved oligomeric Golgi complex subunit 1 |
|
protein binding |
Golgi membrane |
protein transport |
| Conserved oligomeric Golgi complex subunit 4 |
|
|
Golgi membrane |
protein transport |
| Regulator of telomere elongation helicase 1 homolog |
|
DNA binding,
iron-sulfur cluster binding,
metal ion binding,
ATP binding,
ATP-dependent DNA helicase activity |
nucleus |
regulation of double-strand break repair via homologous recombination,
DNA repair |
| Transformer-2 sex-determining protein |
|
RNA binding,
nucleotide binding,
protein binding |
precatalytic spliceosome |
male somatic sex determination,
regulation of alternative nuclear mRNA splicing, via spliceosome,
spliceosome assembly,
spermatogenesis,
female somatic sex determination,
cell differentiation,
sex differentiation |
