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NameDescriptionMolecular FunctionCellular ComponentBiological Process
Plekhm3 Unclassified metal ion binding
Plekho2 Pleckstrin homology domain-containing protein
Plekho1 Unclassified cytoplasm,
nucleus,
membrane
Plexin 2 Unclassified semaphorin receptor activity integral to membrane,
intracellular
limb bud formation,
centrosome localization,
granule cell precursor tangential migration,
pharyngeal system development,
cell surface receptor linked signaling pathway,
neural tube development,
somitogenesis
Triple functional domain protein The Trio guanine nucleotide exchange factor promotes the exchange of GDP by GTP. ATP binding,
Rho guanyl-nucleotide exchange factor activity,
protein serine/threonine kinase activity
cytosol induction of apoptosis by extracellular signals,
apoptosis,
transmembrane receptor protein tyrosine phosphatase signaling pathway,
regulation of Rho protein signal transduction,
protein amino acid phosphorylation
Pleckstrin pleckstrin (platelet p47 protein) (from PhosphoBase) phosphatidylinositol-3,4-bisphosphate binding,
protein kinase C binding,
protein homodimerization activity
extracellular region,
cytosol,
soluble fraction,
membrane fraction,
ruffle membrane
cortical actin cytoskeleton organization,
positive regulation of actin filament depolymerization,
protein kinase C signaling cascade,
protein secretion by platelet,
platelet aggregation,
regulation of cell diameter,
negative regulation of calcium-mediated signaling,
vesicle docking involved in exocytosis,
negative regulation of inositol phosphate biosynthetic process,
actin cytoskeleton reorganization,
positive regulation of actin filament bundle assembly,
integrin-mediated signaling pathway,
inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway,
hemopoietic progenitor cell differentiation,
positive regulation of platelet activation,
phosphoinositide metabolic process,
positive regulation of inositol-polyphosphate 5-phosphatase activity,
positive regulation of integrin activation,
ruffle organization,
thrombin receptor signaling pathway
Neurofilament triplet M protein neurofilament triplet M protein (160 kD neurofilament protein) (from PhosphoBase) structural constituent of cytoskeleton,
structural molecule activity,
protein binding
neurofilament,
neuromuscular junction
intermediate filament bundle assembly,
neurofilament cytoskeleton organization,
regulation of axon diameter,
axon cargo transport,
microtubule cytoskeleton organization
Complement C1r subcomponent complement C1R component precursor (EC 3.4.21.41) (from PhosphoBase) serine-type endopeptidase activity,
calcium ion binding
extracellular region proteolysis,
innate immune response,
complement activation, classical pathway
Complement component 3 Complement protein receptor binding,
endopeptidase inhibitor activity,
protein binding
extracellular space positive regulation vascular endothelial growth factor production,
positive regulation of angiogenesis,
positive regulation of type IIa hypersensitivity,
positive regulation of activation of membrane attack complex,
positive regulation of phagocytosis,
signal transduction,
complement activation, alternative pathway,
complement activation, classical pathway,
G-protein coupled receptor protein signaling pathway
Origin recognition complex subunit 1 DNA binding protein DNA binding,
nucleoside-triphosphatase activity,
ATP binding,
protein binding
cytosol,
origin recognition complex
DNA-dependent DNA replication initiation
Plectin 1 Anchor protein actin binding,
structural constituent of muscle
plasma membrane,
cytosol,
cytoskeleton,
insoluble fraction,
contractile fiber
hemidesmosome assembly
Multiple asters 1 Cytoskeletal associated protein kinetochore binding,
microtubule plus-end binding
condensed chromosome kinetochore,
centrosomal corona,
cytosol,
Golgi apparatus,
cytoplasmic microtubule,
kinetochore microtubule,
cortical microtubule cytoskeleton
exit from mitosis,
establishment or maintenance of cell polarity,
mitosis,
cell division,
negative regulation of microtubule depolymerization,
microtubule bundle formation
Fanconi anemia, complementation group D2 Cell cycle control protein protein binding nucleoplasm DNA repair,
response to gamma radiation
SWI/SNF complex 155 kDa subunit Transcription factor DNA binding,
chromatin binding,
protein N-terminus binding,
transcription coactivator activity
XY body,
npBAF complex,
nBAF complex,
SWI/SNF complex,
nucleoplasm
DNA packaging,
chromatin assembly or disassembly,
chromatin remodeling,
nervous system development,
transcription,
organ morphogenesis,
insulin receptor signaling pathway,
positive regulation of transcription from RNA polymerase II promoter
SWI/SNF complex 170 kDa subunit Transcription factor DNA binding,
chromatin binding,
transcription coactivator activity
npBAF complex,
chromatin,
nBAF complex,
SWI/SNF complex,
nucleoplasm,
nucleus
positive regulation of transcription, DNA-dependent,
chromatin assembly or disassembly,
chromatin remodeling,
nervous system development,
transcription,
regulation of transcription from RNA polymerase II promoter,
negative regulation of transcription, DNA-dependent
G protein-coupled receptor associated sorting protein 2 Unclassified cytoplasm
CCR4-NOT transcription complex subunit 3 Transcription regulatory protein transcription regulator activity,
protein binding
cytoplasm,
nucleus
transcription
Coatomer protein complex, subunit alpha Transport/cargo protein hormone activity,
calcium ion binding,
unfolded protein binding,
structural molecule activity
COPI vesicle coat,
microsome,
cytosol,
soluble fraction,
endoplasmic reticulum,
extracellular space
intracellular protein transport,
pancreatic juice secretion,
retrograde vesicle-mediated transport, Golgi to ER,
protein folding,
COPI coating of Golgi vesicle
Xeroderma pigmentosum group C complementing protein DNA repair protein damaged DNA binding,
single-stranded DNA binding,
protein binding
nucleoplasm,
nucleus
nucleotide-excision repair, DNA damage removal,
intra-S DNA damage checkpoint,
response to UV-B,
nucleotide-excision repair
Exosome complex exonuclease RRP4 Ribonuclease 3`-5`-exoribonuclease activity,
7S RNA binding,
protein binding
exosome (RNase complex),
cytoplasm,
nucleolus
rRNA processing
THO complex, subunit 1 Transcription regulatory protein DNA binding,
RNA binding,
transcription elongation regulator activity,
protein binding
cytoplasm,
nuclear matrix,
nuclear speck,
THO complex part of transcription export complex
intronless viral mRNA export from host nucleus,
apoptosis,
mRNA processing,
transcription,
signal transduction,
RNA splicing
THO complex subunit 2 Transcription factor RNA binding,
protein binding
THO complex part of transcription export complex intronless viral mRNA export from host nucleus,
mRNA processing,
RNA splicing
Symplekin Cell junction protein protein binding cytoplasm,
cytoskeleton,
nucleoplasm,
tight junction
mRNA processing,
cell adhesion
DNA-repair protein complementing XP-A cells homolog DNA repair protein metal ion binding,
damaged DNA binding,
nucleotide binding,
protein homodimerization activity,
protein domain specific binding
nucleoplasm,
nucleus
response to oxidative stress,
response to toxin,
nucleotide-excision repair, DNA damage removal,
DNA damage response, signal transduction resulting in induction of apoptosis,
response to UV,
nucleotide-excision repair
Adaptor protein complex AP-2 alpha-1 subunit Adapter molecule protein transporter activity,
protein binding
plasma membrane,
clathrin adaptor complex,
cytosol,
coated pit,
AP-2 adaptor complex,
clathrin coat of trans-Golgi network vesicle,
stored secretory granule
regulation of defense response to virus by virus,
intracellular protein transport,
endocytosis,
Golgi to endosome transport
Adaptor protein complex AP-3 beta-2 subunit Transport/cargo protein protein transporter activity,
protein binding
membrane coat,
clathrin coated vesicle membrane,
trans-Golgi network
intracellular protein transport,
endocytosis
Anaphase promoting complex subunit 1 Cell cycle control protein cytosol,
anaphase-promoting complex,
nucleoplasm
protein K11-linked ubiquitination,
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
mitosis,
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process,
cell division,
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Anaphase promoting complex subunit 2 Cell cycle control protein ubiquitin-protein ligase activity,
ubiquitin protein ligase binding
cytosol,
anaphase-promoting complex,
cullin-RING ubiquitin ligase complex,
nucleoplasm
cyclin catabolic process,
regulation of cyclin-dependent protein kinase activity,
protein K11-linked ubiquitination,
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
mitosis,
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process,
cell division,
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Anaphase promoting complex subunit 4 Cell cycle control protein ubiquitin-protein ligase activity cytosol,
anaphase-promoting complex,
nucleoplasm
protein K11-linked ubiquitination,
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process,
cell division,
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
G2/M transition of mitotic cell cycle,
mitotic anaphase
Anaphase promoting complex subunit 5 Cell cycle control protein binding,
ubiquitin-protein ligase activity
cytosol,
anaphase-promoting complex,
nucleoplasm
protein K11-linked ubiquitination,
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process,
cell division,
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
G2/M transition of mitotic cell cycle,
mitotic anaphase
Anaphase promoting complex subunit 7 Cell cycle control protein cytosol,
anaphase-promoting complex,
nucleoplasm
protein K11-linked ubiquitination,
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
mitosis,
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process,
cell division,
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
DASH complex subunit ASK1 Cytoskeletal protein of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore structural constituent of cytoskeleton,
protein binding
spindle,
cytoplasm,
microtubule,
DASH complex
mitosis,
mitotic spindle organization in nucleus,
regulation of microtubule polymerization or depolymerization,
cell division,
chromosome segregation
DASH complex subunit DAM1 Cytoskeletal protein of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore identical protein binding,
structural constituent of cytoskeleton
cytoplasm,
kinetochore microtubule,
DASH complex,
spindle midzone
mitosis,
mitotic spindle organization in nucleus,
regulation of microtubule polymerization or depolymerization,
cell division,
chromosome segregation
DASH complex subunit SPC19 Cytoskeletal protein of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore structural constituent of cytoskeleton,
protein binding
spindle pole body,
spindle microtubule,
DASH complex
mitosis,
mitotic spindle organization in nucleus,
regulation of microtubule polymerization or depolymerization,
cell division,
chromosome segregation,
microtubule nucleation
DASH complex subunit SPC34 Cytoskeletal protein of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore identical protein binding,
structural constituent of cytoskeleton
spindle pole body,
spindle microtubule,
DASH complex
mitosis,
mitotic spindle organization in nucleus,
regulation of microtubule polymerization or depolymerization,
cell division,
chromosome segregation,
microtubule nucleation
Gamma-tubulin complex component 2 Gamma-tubulin complex is necessary for microtublule nucleation at the centrosome protein binding cytosol,
cytoplasmic microtubule,
spindle pole,
microtubule organizing center
protein complex assembly,
microtubule nucleation
G-protein coupled receptor homolog US28 Receptor for a C-C type chemokine C-C chemokine receptor activity integral to membrane,
host cell plasma membrane
SH3 and multiple ankyrin repeat domains protein 1 Unclassified somatostatin receptor binding,
receptor signaling complex scaffold activity,
ionotropic glutamate receptor binding,
protein binding
cell junction,
cytoplasm,
membrane fraction,
dendrite,
postsynaptic membrane,
postsynaptic density
cytoskeletal anchoring at plasma membrane
Plekha6 Unclassified
Plekha7 Unclassified delta-catenin binding centrosome,
zonula adherens
epithelial cell-cell adhesion,
zonula adherens maintenance
CRSP complex subunit 7 transcription coactivator activity DNA binding,
RNA polymerase II transcription mediator activity,
transcription coactivator activity,
protein binding
mediator complex phagocytosis, engulfment,
transcription,
regulation of transcription from RNA polymerase II promoter,
transcription initiation from RNA polymerase II promoter
G protein-coupled receptor 56 G-protein coupled receptor activity G-protein coupled receptor activity integral to plasma membrane neuropeptide signaling pathway,
cell-cell signaling,
brain development,
cell adhesion
N-terminal acetyltransferase complex ARD1 subunit homolog N-acetyltransferase activity peptide alpha-N-acetyltransferase activity,
protein binding
cytoplasm,
nucleus
DNA packaging,
N-terminal protein amino acid acetylation,
internal protein amino acid acetylation
Nuclear pore complex protein Nup88 transporter activity transporter activity cytosol,
nuclear pore
transmembrane transport,
mRNA transport,
protein transport
Origin recognition complex subunit 6 protein binding DNA binding,
protein binding
nuclear origin of replication recognition complex DNA replication
Pleckstrin homology domain containing family G member 1 guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity intracellular regulation of Rho protein signal transduction
Pleckstrin homology domain containing, family G, member 3 unclassified Rho guanyl-nucleotide exchange factor activity intracellular regulation of Rho protein signal transduction
Probable G-protein coupled receptor 128 precursor receptor activity G-protein coupled receptor activity plasma membrane,
integral to membrane
neuropeptide signaling pathway
Adapter-related protein complex 3 beta 1 subunit unclassified protein transporter activity,
protein phosphatase binding
membrane coat,
Golgi apparatus,
clathrin coated vesicle membrane,
trans-Golgi network
positive regulation of NK T cell differentiation,
endocytosis,
blood coagulation,
antigen processing and presentation, exogenous lipid antigen via MHC class Ib,
protein targeting to lysosome,
zinc ion transport
Multiple myeloma tumor-associated protein 2 unclassified
PLEKHA5 protein binding phosphatidylinositol binding,
protein binding
Probable G-protein coupled receptor 125 precursor G-protein coupled receptor activity G-protein coupled receptor activity,
protein binding
integral to membrane neuropeptide signaling pathway
Multiple PDZ domain protein protein binding protein C-terminus binding synaptosome,
apical plasma membrane,
dendrite,
postsynaptic membrane,
postsynaptic density,
tight junction
interspecies interaction between organisms
PLEKHC1 protein binding stress fiber,
cytosol,
focal adhesion,
cell cortex
actin cytoskeleton organization,
regulation of cell shape,
cell adhesion
Mothers against decapentaplegic homolog 9 unclassified transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity,
sequence-specific DNA binding transcription factor activity
cytosol,
transcription factor complex
regulation of transcription, DNA-dependent,
transcription,
BMP signaling pathway,
transforming growth factor beta receptor signaling pathway
T-complex protein 1, alpha subunit unfolded protein binding ATP binding,
unfolded protein binding
tubulin complex assembly,
protein folding
Plekha2 Unclassified PDZ domain binding,
laminin binding,
fibronectin binding,
phosphatidylinositol binding
plasma membrane,
cytoplasm,
protein complex,
nucleus
positive regulation of cell-matrix adhesion
POSH (Plenty of SH3 domains) RING finger protein ligase activity,
zinc ion binding
Golgi apparatus,
perinuclear region of cytoplasm,
lamellipodium
Plexin-A1 protein binding semaphorin receptor activity,
protein binding
plasma membrane,
integral to membrane,
membrane fraction,
intracellular
dichotomous subdivision of terminal units involved in salivary gland branching
TFIIH basal transcription factor complex TTD-A subunit DNA binding nucleus regulation of transcription,
transcription,
nucleotide-excision repair
Anaphase-promoting complex subunit CDC26 cytosol,
anaphase-promoting complex,
nucleoplasm
protein K11-linked ubiquitination,
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
mitosis,
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process,
cell division,
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
snRNA-activating protein complex subunit 3 DNA binding,
protein binding
nucleus regulation of transcription,
transcription from RNA polymerase II promoter,
snRNA transcription,
transcription from RNA polymerase III promoter
DNA replication complex GINS protein PSF2. protein binding nucleus DNA replication
Integrator complex subunit 2 protein binding integral to membrane,
integrator complex,
nuclear membrane
snRNA processing
Leucine-rich repeat-containing G-protein coupled receptor 6 precursor. protein-hormone receptor activity,
protein binding
plasma membrane,
integral to membrane
Plexin-A4 precursor. plasma membrane,
integral to membrane,
intracellular
Origin recognition complex subunit 3 DNA binding,
DNA replication origin binding,
protein binding
nuclear origin of replication recognition complex DNA replication
G-protein coupled receptor family C group 5 member C precursor G-protein coupled receptor activity,
protein binding
cytoplasmic vesicle membrane,
integral to plasma membrane
PLEK2 cytoplasm,
cytoskeleton,
lamellipodium membrane
actin cytoskeleton organization
CCR4-NOT transcription complex subunit 2 RNA polymerase II transcription mediator activity,
protein binding
cytoplasm,
nucleus
regulation of transcription from RNA polymerase II promoter, global,
transcription
COP9 signalosome complex subunit 7a cytoplasm,
signalosome
CGG triplet repeat-binding protein 1 double-stranded DNA binding nucleus regulation of transcription,
transcription
COP9 signalosome complex subunit 3 protein binding cytoplasm,
signalosome
response to light stimulus,
signal transduction
Chromatin-remodeling complex ATPase chain Iswi DNA binding,
DNA helicase activity,
DNA-dependent ATPase activity,
nucleosome binding,
ATP binding,
protein binding
transcription factor complex,
polytene chromosome,
ACF complex,
NURF complex,
chromatin accessibility complex,
RSF complex
dendrite morphogenesis,
negative regulation of gene-specific transcription,
positive regulation of transcription,
transcription,
nucleosome assembly,
regulation of circadian rhythm,
ecdysone receptor-mediated signaling pathway,
muscle organ development,
nucleosome mobilization,
nucleosome positioning,
ATP-dependent chromatin remodeling
Conserved oligomeric Golgi complex subunit 1 protein binding Golgi membrane protein transport
Conserved oligomeric Golgi complex subunit 4 Golgi membrane protein transport
COP9 signalosome complex subunit 5 NEDD8 activating enzyme activity,
metal ion binding,
metallopeptidase activity,
protein binding
cytoplasm,
signalosome
protein stabilization,
protein deneddylation,
compound eye photoreceptor cell differentiation,
oocyte anterior/posterior axis specification,
axonogenesis,
glial cell migration,
positive regulation of cell cycle,
oocyte dorsal/ventral axis specification,
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
COP9 signalosome complex subunit 7 NEDD8 activating enzyme activity,
protein binding
cytoplasm,
signalosome
protein stabilization,
protein deneddylation,
oogenesis,
cell differentiation,
multicellular organismal development
FACT complex subunit spt16 FACT complex,
chromosome
regulation of transcription,
DNA replication,
transcription,
DNA repair,
regulation of chromatin assembly or disassembly
G protein-coupled receptor kinase 2 G-protein coupled receptor kinase activity,
ATP binding,
signal transducer activity
membrane oogenesis,
protein amino acid phosphorylation,
cell differentiation,
multicellular organismal development
H/ACA ribonucleoprotein complex non-core subunit NAF1 pseudouridine synthase activity,
snoRNA binding
box H/ACA snoRNP complex rRNA processing
Integrator complex subunit 3 homolog
Mediator complex subunit Kohtalo RNA polymerase II transcription mediator activity,
protein binding
mediator complex transcription,
regulation of transcription from RNA polymerase II promoter,
positive regulation of Wnt receptor signaling pathway,
multicellular organismal development
Probable 26S proteasome complex subunit sem1 peptidase activity,
protein binding
proteasome complex proteolysis
Protein wech Protein dappled zinc ion binding muscle tendon junction,
intracellular
instar larval development,
cell differentiation,
muscle attachment
Signal peptidase complex subunit 1 peptidase activity microsome,
integral to membrane,
signal peptidase complex
signal peptide processing
THO complex protein 7 protein binding THO complex,
cytoplasm
cell proliferation,
response to heat
THO complex subunit 5 THO complex,
cytoplasm
cell proliferation,
response to heat
WASH complex subunit FAM21 homolog
PLEKHG4 Rho guanyl-nucleotide exchange factor activity intracellular regulation of Rho protein signal transduction
PLEKHG2 Rho guanyl-nucleotide exchange factor activity cytosol induction of apoptosis by extracellular signals,
apoptosis,
regulation of Rho protein signal transduction
PLEKHA3 phospholipid binding cytoplasm,
membrane
PLEKHA1 phosphatidylinositol-3,4-bisphosphate binding,
PDZ domain binding
cytoplasm,
ruffle membrane,
nucleus
establishment of protein localization,
B cell receptor signaling pathway,
cellular response to hydrogen peroxide,
phosphoinositide 3-kinase cascade,
negative regulation of protein kinase B signaling cascade,
ruffle organization
Daple PDZ domain binding,
protein self-association
insoluble fraction Wnt receptor signaling pathway,
regulation of protein amino acid phosphorylation,
protein homooligomerization,
protein destabilization
ple Tyrosine 3-monooxygenase tyrosine 3-monooxygenase activity,
iron ion binding,
protein binding
dopamine biosynthetic process,
neurotransmitter biosynthetic process,
oxidation reduction,
adult locomotory behavior,
developmental pigmentation,
male courtship behavior,
aromatic amino acid family metabolic process
Gamma-tubulin complex component 5
Anaphase-promoting complex subunit 16
Gamma-tubulin complex component 4

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