Name | Description | Molecular Function | Cellular Component | Biological Process |
Plekhm3 |
Unclassified |
metal ion binding |
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Plekho2 |
Pleckstrin homology domain-containing protein |
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Plekho1 |
Unclassified |
|
cytoplasm, nucleus, membrane |
|
Plexin 2 |
Unclassified |
semaphorin receptor activity |
integral to membrane, intracellular |
limb bud formation, centrosome localization, granule cell precursor tangential migration, pharyngeal system development, cell surface receptor linked signaling pathway, neural tube development, somitogenesis |
Triple functional domain protein |
The Trio guanine nucleotide exchange factor promotes the exchange of GDP by GTP. |
ATP binding, Rho guanyl-nucleotide exchange factor activity, protein serine/threonine kinase activity |
cytosol |
induction of apoptosis by extracellular signals, apoptosis, transmembrane receptor protein tyrosine phosphatase signaling pathway, regulation of Rho protein signal transduction, protein amino acid phosphorylation |
Pleckstrin |
pleckstrin (platelet p47 protein) (from PhosphoBase) |
phosphatidylinositol-3,4-bisphosphate binding, protein kinase C binding, protein homodimerization activity |
extracellular region, cytosol, soluble fraction, membrane fraction, ruffle membrane |
cortical actin cytoskeleton organization, positive regulation of actin filament depolymerization, protein kinase C signaling cascade, protein secretion by platelet, platelet aggregation, regulation of cell diameter, negative regulation of calcium-mediated signaling, vesicle docking involved in exocytosis, negative regulation of inositol phosphate biosynthetic process, actin cytoskeleton reorganization, positive regulation of actin filament bundle assembly, integrin-mediated signaling pathway, inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway, hemopoietic progenitor cell differentiation, positive regulation of platelet activation, phosphoinositide metabolic process, positive regulation of inositol-polyphosphate 5-phosphatase activity, positive regulation of integrin activation, ruffle organization, thrombin receptor signaling pathway |
Neurofilament triplet M protein |
neurofilament triplet M protein (160 kD neurofilament protein) (from PhosphoBase) |
structural constituent of cytoskeleton, structural molecule activity, protein binding |
neurofilament, neuromuscular junction |
intermediate filament bundle assembly, neurofilament cytoskeleton organization, regulation of axon diameter, axon cargo transport, microtubule cytoskeleton organization |
Complement C1r subcomponent |
complement C1R component precursor (EC 3.4.21.41) (from PhosphoBase) |
serine-type endopeptidase activity, calcium ion binding |
extracellular region |
proteolysis, innate immune response, complement activation, classical pathway |
Complement component 3 |
Complement protein |
receptor binding, endopeptidase inhibitor activity, protein binding |
extracellular space |
positive regulation vascular endothelial growth factor production, positive regulation of angiogenesis, positive regulation of type IIa hypersensitivity, positive regulation of activation of membrane attack complex, positive regulation of phagocytosis, signal transduction, complement activation, alternative pathway, complement activation, classical pathway, G-protein coupled receptor protein signaling pathway |
Origin recognition complex subunit 1 |
DNA binding protein |
DNA binding, nucleoside-triphosphatase activity, ATP binding, protein binding |
cytosol, origin recognition complex |
DNA-dependent DNA replication initiation |
Plectin 1 |
Anchor protein |
actin binding, structural constituent of muscle |
plasma membrane, cytosol, cytoskeleton, insoluble fraction, contractile fiber |
hemidesmosome assembly |
Multiple asters 1 |
Cytoskeletal associated protein |
kinetochore binding, microtubule plus-end binding |
condensed chromosome kinetochore, centrosomal corona, cytosol, Golgi apparatus, cytoplasmic microtubule, kinetochore microtubule, cortical microtubule cytoskeleton |
exit from mitosis, establishment or maintenance of cell polarity, mitosis, cell division, negative regulation of microtubule depolymerization, microtubule bundle formation |
Fanconi anemia, complementation group D2 |
Cell cycle control protein |
protein binding |
nucleoplasm |
DNA repair, response to gamma radiation |
SWI/SNF complex 155 kDa subunit |
Transcription factor |
DNA binding, chromatin binding, protein N-terminus binding, transcription coactivator activity |
XY body, npBAF complex, nBAF complex, SWI/SNF complex, nucleoplasm |
DNA packaging, chromatin assembly or disassembly, chromatin remodeling, nervous system development, transcription, organ morphogenesis, insulin receptor signaling pathway, positive regulation of transcription from RNA polymerase II promoter |
SWI/SNF complex 170 kDa subunit |
Transcription factor |
DNA binding, chromatin binding, transcription coactivator activity |
npBAF complex, chromatin, nBAF complex, SWI/SNF complex, nucleoplasm, nucleus |
positive regulation of transcription, DNA-dependent, chromatin assembly or disassembly, chromatin remodeling, nervous system development, transcription, regulation of transcription from RNA polymerase II promoter, negative regulation of transcription, DNA-dependent |
G protein-coupled receptor associated sorting protein 2 |
Unclassified |
|
cytoplasm |
|
CCR4-NOT transcription complex subunit 3 |
Transcription regulatory protein |
transcription regulator activity, protein binding |
cytoplasm, nucleus |
transcription |
Coatomer protein complex, subunit alpha |
Transport/cargo protein |
hormone activity, calcium ion binding, unfolded protein binding, structural molecule activity |
COPI vesicle coat, microsome, cytosol, soluble fraction, endoplasmic reticulum, extracellular space |
intracellular protein transport, pancreatic juice secretion, retrograde vesicle-mediated transport, Golgi to ER, protein folding, COPI coating of Golgi vesicle |
Xeroderma pigmentosum group C complementing protein |
DNA repair protein |
damaged DNA binding, single-stranded DNA binding, protein binding |
nucleoplasm, nucleus |
nucleotide-excision repair, DNA damage removal, intra-S DNA damage checkpoint, response to UV-B, nucleotide-excision repair |
Exosome complex exonuclease RRP4 |
Ribonuclease |
3`-5`-exoribonuclease activity, 7S RNA binding, protein binding |
exosome (RNase complex), cytoplasm, nucleolus |
rRNA processing |
THO complex, subunit 1 |
Transcription regulatory protein |
DNA binding, RNA binding, transcription elongation regulator activity, protein binding |
cytoplasm, nuclear matrix, nuclear speck, THO complex part of transcription export complex |
intronless viral mRNA export from host nucleus, apoptosis, mRNA processing, transcription, signal transduction, RNA splicing |
THO complex subunit 2 |
Transcription factor |
RNA binding, protein binding |
THO complex part of transcription export complex |
intronless viral mRNA export from host nucleus, mRNA processing, RNA splicing |
Symplekin |
Cell junction protein |
protein binding |
cytoplasm, cytoskeleton, nucleoplasm, tight junction |
mRNA processing, cell adhesion |
DNA-repair protein complementing XP-A cells homolog |
DNA repair protein |
metal ion binding, damaged DNA binding, nucleotide binding, protein homodimerization activity, protein domain specific binding |
nucleoplasm, nucleus |
response to oxidative stress, response to toxin, nucleotide-excision repair, DNA damage removal, DNA damage response, signal transduction resulting in induction of apoptosis, response to UV, nucleotide-excision repair |
Adaptor protein complex AP-2 alpha-1 subunit |
Adapter molecule |
protein transporter activity, protein binding |
plasma membrane, clathrin adaptor complex, cytosol, coated pit, AP-2 adaptor complex, clathrin coat of trans-Golgi network vesicle, stored secretory granule |
regulation of defense response to virus by virus, intracellular protein transport, endocytosis, Golgi to endosome transport |
Adaptor protein complex AP-3 beta-2 subunit |
Transport/cargo protein |
protein transporter activity, protein binding |
membrane coat, clathrin coated vesicle membrane, trans-Golgi network |
intracellular protein transport, endocytosis |
Anaphase promoting complex subunit 1 |
Cell cycle control protein |
|
cytosol, anaphase-promoting complex, nucleoplasm |
protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, mitosis, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
Anaphase promoting complex subunit 2 |
Cell cycle control protein |
ubiquitin-protein ligase activity, ubiquitin protein ligase binding |
cytosol, anaphase-promoting complex, cullin-RING ubiquitin ligase complex, nucleoplasm |
cyclin catabolic process, regulation of cyclin-dependent protein kinase activity, protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, mitosis, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
Anaphase promoting complex subunit 4 |
Cell cycle control protein |
ubiquitin-protein ligase activity |
cytosol, anaphase-promoting complex, nucleoplasm |
protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, G2/M transition of mitotic cell cycle, mitotic anaphase |
Anaphase promoting complex subunit 5 |
Cell cycle control protein |
binding, ubiquitin-protein ligase activity |
cytosol, anaphase-promoting complex, nucleoplasm |
protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, G2/M transition of mitotic cell cycle, mitotic anaphase |
Anaphase promoting complex subunit 7 |
Cell cycle control protein |
|
cytosol, anaphase-promoting complex, nucleoplasm |
protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, mitosis, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
DASH complex subunit ASK1 |
Cytoskeletal protein of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore |
structural constituent of cytoskeleton, protein binding |
spindle, cytoplasm, microtubule, DASH complex |
mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization, cell division, chromosome segregation |
DASH complex subunit DAM1 |
Cytoskeletal protein of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore |
identical protein binding, structural constituent of cytoskeleton |
cytoplasm, kinetochore microtubule, DASH complex, spindle midzone |
mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization, cell division, chromosome segregation |
DASH complex subunit SPC19 |
Cytoskeletal protein of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore |
structural constituent of cytoskeleton, protein binding |
spindle pole body, spindle microtubule, DASH complex |
mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization, cell division, chromosome segregation, microtubule nucleation |
DASH complex subunit SPC34 |
Cytoskeletal protein of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore |
identical protein binding, structural constituent of cytoskeleton |
spindle pole body, spindle microtubule, DASH complex |
mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization, cell division, chromosome segregation, microtubule nucleation |
Gamma-tubulin complex component 2 |
Gamma-tubulin complex is necessary for microtublule nucleation at the centrosome |
protein binding |
cytosol, cytoplasmic microtubule, spindle pole, microtubule organizing center |
protein complex assembly, microtubule nucleation |
G-protein coupled receptor homolog US28 |
Receptor for a C-C type chemokine |
C-C chemokine receptor activity |
integral to membrane, host cell plasma membrane |
|
SH3 and multiple ankyrin repeat domains protein 1 |
Unclassified |
somatostatin receptor binding, receptor signaling complex scaffold activity, ionotropic glutamate receptor binding, protein binding |
cell junction, cytoplasm, membrane fraction, dendrite, postsynaptic membrane, postsynaptic density |
cytoskeletal anchoring at plasma membrane |
Plekha6 |
Unclassified |
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|
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Plekha7 |
Unclassified |
delta-catenin binding |
centrosome, zonula adherens |
epithelial cell-cell adhesion, zonula adherens maintenance |
CRSP complex subunit 7 |
transcription coactivator activity |
DNA binding, RNA polymerase II transcription mediator activity, transcription coactivator activity, protein binding |
mediator complex |
phagocytosis, engulfment, transcription, regulation of transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter |
G protein-coupled receptor 56 |
G-protein coupled receptor activity |
G-protein coupled receptor activity |
integral to plasma membrane |
neuropeptide signaling pathway, cell-cell signaling, brain development, cell adhesion |
N-terminal acetyltransferase complex ARD1 subunit homolog |
N-acetyltransferase activity |
peptide alpha-N-acetyltransferase activity, protein binding |
cytoplasm, nucleus |
DNA packaging, N-terminal protein amino acid acetylation, internal protein amino acid acetylation |
Nuclear pore complex protein Nup88 |
transporter activity |
transporter activity |
cytosol, nuclear pore |
transmembrane transport, mRNA transport, protein transport |
Origin recognition complex subunit 6 |
protein binding |
DNA binding, protein binding |
nuclear origin of replication recognition complex |
DNA replication |
Pleckstrin homology domain containing family G member 1 |
guanyl-nucleotide exchange factor activity |
Rho guanyl-nucleotide exchange factor activity |
intracellular |
regulation of Rho protein signal transduction |
Pleckstrin homology domain containing, family G, member 3 |
unclassified |
Rho guanyl-nucleotide exchange factor activity |
intracellular |
regulation of Rho protein signal transduction |
Probable G-protein coupled receptor 128 precursor |
receptor activity |
G-protein coupled receptor activity |
plasma membrane, integral to membrane |
neuropeptide signaling pathway |
Adapter-related protein complex 3 beta 1 subunit |
unclassified |
protein transporter activity, protein phosphatase binding |
membrane coat, Golgi apparatus, clathrin coated vesicle membrane, trans-Golgi network |
positive regulation of NK T cell differentiation, endocytosis, blood coagulation, antigen processing and presentation, exogenous lipid antigen via MHC class Ib, protein targeting to lysosome, zinc ion transport |
Multiple myeloma tumor-associated protein 2 |
unclassified |
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PLEKHA5 |
protein binding |
phosphatidylinositol binding, protein binding |
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Probable G-protein coupled receptor 125 precursor |
G-protein coupled receptor activity |
G-protein coupled receptor activity, protein binding |
integral to membrane |
neuropeptide signaling pathway |
Multiple PDZ domain protein |
protein binding |
protein C-terminus binding |
synaptosome, apical plasma membrane, dendrite, postsynaptic membrane, postsynaptic density, tight junction |
interspecies interaction between organisms |
PLEKHC1 |
protein binding |
|
stress fiber, cytosol, focal adhesion, cell cortex |
actin cytoskeleton organization, regulation of cell shape, cell adhesion |
Mothers against decapentaplegic homolog 9 |
unclassified |
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity, sequence-specific DNA binding transcription factor activity |
cytosol, transcription factor complex |
regulation of transcription, DNA-dependent, transcription, BMP signaling pathway, transforming growth factor beta receptor signaling pathway |
T-complex protein 1, alpha subunit |
unfolded protein binding |
ATP binding, unfolded protein binding |
|
tubulin complex assembly, protein folding |
Plekha2 |
Unclassified |
PDZ domain binding, laminin binding, fibronectin binding, phosphatidylinositol binding |
plasma membrane, cytoplasm, protein complex, nucleus |
positive regulation of cell-matrix adhesion |
POSH (Plenty of SH3 domains) |
RING finger protein |
ligase activity, zinc ion binding |
Golgi apparatus, perinuclear region of cytoplasm, lamellipodium |
|
Plexin-A1 |
protein binding |
semaphorin receptor activity, protein binding |
plasma membrane, integral to membrane, membrane fraction, intracellular |
dichotomous subdivision of terminal units involved in salivary gland branching |
TFIIH basal transcription factor complex TTD-A subunit |
|
DNA binding |
nucleus |
regulation of transcription, transcription, nucleotide-excision repair |
Anaphase-promoting complex subunit CDC26 |
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cytosol, anaphase-promoting complex, nucleoplasm |
protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, mitosis, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
snRNA-activating protein complex subunit 3 |
|
DNA binding, protein binding |
nucleus |
regulation of transcription, transcription from RNA polymerase II promoter, snRNA transcription, transcription from RNA polymerase III promoter |
DNA replication complex GINS protein PSF2. |
|
protein binding |
nucleus |
DNA replication |
Integrator complex subunit 2 |
|
protein binding |
integral to membrane, integrator complex, nuclear membrane |
snRNA processing |
Leucine-rich repeat-containing G-protein coupled receptor 6 precursor. |
|
protein-hormone receptor activity, protein binding |
plasma membrane, integral to membrane |
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Plexin-A4 precursor. |
|
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plasma membrane, integral to membrane, intracellular |
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Origin recognition complex subunit 3 |
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DNA binding, DNA replication origin binding, protein binding |
nuclear origin of replication recognition complex |
DNA replication |
G-protein coupled receptor family C group 5 member C precursor |
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G-protein coupled receptor activity, protein binding |
cytoplasmic vesicle membrane, integral to plasma membrane |
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PLEK2 |
|
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cytoplasm, cytoskeleton, lamellipodium membrane |
actin cytoskeleton organization |
CCR4-NOT transcription complex subunit 2 |
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RNA polymerase II transcription mediator activity, protein binding |
cytoplasm, nucleus |
regulation of transcription from RNA polymerase II promoter, global, transcription |
COP9 signalosome complex subunit 7a |
|
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cytoplasm, signalosome |
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CGG triplet repeat-binding protein 1 |
|
double-stranded DNA binding |
nucleus |
regulation of transcription, transcription |
COP9 signalosome complex subunit 3 |
|
protein binding |
cytoplasm, signalosome |
response to light stimulus, signal transduction |
Chromatin-remodeling complex ATPase chain Iswi |
|
DNA binding, DNA helicase activity, DNA-dependent ATPase activity, nucleosome binding, ATP binding, protein binding |
transcription factor complex, polytene chromosome, ACF complex, NURF complex, chromatin accessibility complex, RSF complex |
dendrite morphogenesis, negative regulation of gene-specific transcription, positive regulation of transcription, transcription, nucleosome assembly, regulation of circadian rhythm, ecdysone receptor-mediated signaling pathway, muscle organ development, nucleosome mobilization, nucleosome positioning, ATP-dependent chromatin remodeling |
Conserved oligomeric Golgi complex subunit 1 |
|
protein binding |
Golgi membrane |
protein transport |
Conserved oligomeric Golgi complex subunit 4 |
|
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Golgi membrane |
protein transport |
COP9 signalosome complex subunit 5 |
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NEDD8 activating enzyme activity, metal ion binding, metallopeptidase activity, protein binding |
cytoplasm, signalosome |
protein stabilization, protein deneddylation, compound eye photoreceptor cell differentiation, oocyte anterior/posterior axis specification, axonogenesis, glial cell migration, positive regulation of cell cycle, oocyte dorsal/ventral axis specification, negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
COP9 signalosome complex subunit 7 |
|
NEDD8 activating enzyme activity, protein binding |
cytoplasm, signalosome |
protein stabilization, protein deneddylation, oogenesis, cell differentiation, multicellular organismal development |
FACT complex subunit spt16 |
|
|
FACT complex, chromosome |
regulation of transcription, DNA replication, transcription, DNA repair, regulation of chromatin assembly or disassembly |
G protein-coupled receptor kinase 2 |
|
G-protein coupled receptor kinase activity, ATP binding, signal transducer activity |
membrane |
oogenesis, protein amino acid phosphorylation, cell differentiation, multicellular organismal development |
H/ACA ribonucleoprotein complex non-core subunit NAF1 |
|
pseudouridine synthase activity, snoRNA binding |
box H/ACA snoRNP complex |
rRNA processing |
Integrator complex subunit 3 homolog |
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Mediator complex subunit Kohtalo |
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RNA polymerase II transcription mediator activity, protein binding |
mediator complex |
transcription, regulation of transcription from RNA polymerase II promoter, positive regulation of Wnt receptor signaling pathway, multicellular organismal development |
Probable 26S proteasome complex subunit sem1 |
|
peptidase activity, protein binding |
proteasome complex |
proteolysis |
Protein wech Protein dappled |
|
zinc ion binding |
muscle tendon junction, intracellular |
instar larval development, cell differentiation, muscle attachment |
Signal peptidase complex subunit 1 |
|
peptidase activity |
microsome, integral to membrane, signal peptidase complex |
signal peptide processing |
THO complex protein 7 |
|
protein binding |
THO complex, cytoplasm |
cell proliferation, response to heat |
THO complex subunit 5 |
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THO complex, cytoplasm |
cell proliferation, response to heat |
WASH complex subunit FAM21 homolog |
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PLEKHG4 |
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Rho guanyl-nucleotide exchange factor activity |
intracellular |
regulation of Rho protein signal transduction |
PLEKHG2 |
|
Rho guanyl-nucleotide exchange factor activity |
cytosol |
induction of apoptosis by extracellular signals, apoptosis, regulation of Rho protein signal transduction |
PLEKHA3 |
|
phospholipid binding |
cytoplasm, membrane |
|
PLEKHA1 |
|
phosphatidylinositol-3,4-bisphosphate binding, PDZ domain binding |
cytoplasm, ruffle membrane, nucleus |
establishment of protein localization, B cell receptor signaling pathway, cellular response to hydrogen peroxide, phosphoinositide 3-kinase cascade, negative regulation of protein kinase B signaling cascade, ruffle organization |
Daple |
|
PDZ domain binding, protein self-association |
insoluble fraction |
Wnt receptor signaling pathway, regulation of protein amino acid phosphorylation, protein homooligomerization, protein destabilization |
ple |
Tyrosine 3-monooxygenase |
tyrosine 3-monooxygenase activity, iron ion binding, protein binding |
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dopamine biosynthetic process, neurotransmitter biosynthetic process, oxidation reduction, adult locomotory behavior, developmental pigmentation, male courtship behavior, aromatic amino acid family metabolic process |
Gamma-tubulin complex component 5 |
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Anaphase-promoting complex subunit 16 |
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Gamma-tubulin complex component 4 |
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