Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: P56945 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74936   PTN12_HUMAN
MINT-74938   FAK1_HUMAN
MINT-3974941   1433S_HUMAN
MINT-6174734   ACTB_HUMAN
MINT-6763936   CRK_HUMAN
MINT-6793484   PTN1_HUMAN
MINT-7104353   CDC42_HUMAN
MINT-7104422   SRC_HUMAN
MINT-7104436   ACK1_HUMAN
MINT-7247002   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein kinase binding,
protein phosphatase binding,
signal transducer activity		 focal adhesion,
membrane fraction,
cytosol,
ruffle		 regulation of cell growth,
B cell receptor signaling pathway,
cell division,
positive regulation of cell migration,
nerve growth factor receptor signaling pathway,
cell migration,
integrin-mediated signaling pathway,
epidermal growth factor receptor signaling pathway,
actin filament organization,
regulation of apoptosis,
platelet-derived growth factor receptor signaling pathway,
T cell receptor signaling pathway,
cell adhesion,
insulin receptor signaling pathway,
cell proliferation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 128 PTPSKAQQGLYQVPGPSPQFQ FGFR1 12601080
LTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 128 PTPSKAQQGLYQVPGPSPQFQ - 18083107
HTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 128 PTPSKAQQGLYQVPGPSPQFQ - 16212419
HTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
S 134 QQGLYQVPGPSPQFQSPPAKQ - 18669648
HTP
0.98
 - -
0.79
 - medium
S 139 QVPGPSPQFQSPPAKQTSTFS - 16964243
HTP
0.02
 - -
0.83
 - medium
S 139 QVPGPSPQFQSPPAKQTSTFS - 18669648
HTP
0.02
 - -
0.83
 - medium
Y 165 HPFPSPATDLYQVPPGPGGPA - 15817476
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.85
 - medium
Y 222 VVVPTRVGQGYVYEAAQPEQD - 16212419
HTP
1.00
 - -
0.60
 - medium
Y 224 VPTRVGQGYVYEAAQPEQDEY - 16212419
HTP
0.99
 - -
0.64
 - medium
Y 234 YEAAQPEQDEYDIPRHLLAPG - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2		 -
0.71
 - medium
Y 234 YEAAQPEQDEYDIPRHLLAPG - 16212419
HTP
1.00
 CRKL SH2;
CRK SH2		 -
0.71
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP FGFR1 12601080
LTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 16212419
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
T 269 PSQYGQEVYDTPPMAVKGPNG - 18669648
HTP
0.18
 - -
0.73
 - medium
S 292 PLLEVYDVPPSVEKGLPPSNH - 18669648
HTP
1.00
 - -
0.65
 - medium
Y 306 GLPPSNHHAVYDVPPSVSKDV FGFR1 12601080
LTP
0.94
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 327 PDGPLLREETYDVPPAFAKAK FGFR1 12601080
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.61
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 15316024
LTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 18083107
HTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 16212419
HTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 410 ADGGVVDSGVYAVPPPAEREA FGFR1 12601080
LTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.72
 - medium
S 639 TSSIQSRPLPSPPKFTSQDSP - 17081983
HTP
0.18
 - -
0.88
 - medium
Y 653 FTSQDSPDGQYENSEGGWMED SRC 11604500
LTP
1.00
 GRB2 SH2;
Src SH2		 -
0.75
 - medium
Y 653 FTSQDSPDGQYENSEGGWMED - 8670206
LTP
1.00
 GRB2 SH2;
Src SH2		 -
0.75
 - medium
Y 653 FTSQDSPDGQYENSEGGWMED - 12480533
LTP
1.00
 GRB2 SH2;
Src SH2		 -
0.75
 - medium
Y 664 ENSEGGWMEDYDYVHLQGKEE - 8621540
LTP
1.00
 FES SH2;
Fyn SH2;
Lck SH2;
Src SH2		 -
0.49
 - medium
Y 664 ENSEGGWMEDYDYVHLQGKEE - 11604500
LTP
1.00
 FES SH2;
Fyn SH2;
Lck SH2;
Src SH2		 -
0.49
 - medium

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: Q61140 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19527   FYN_MOUSE
MINT-58759   LYN_MOUSE
MINT-6763504   PTN1_HUMAN
MINT-7303491   FAK1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding focal adhesion,
membrane fraction,
cytoplasm,
lamellipodium,
ruffle		 B cell receptor signaling pathway,
positive regulation of cell migration,
nerve growth factor receptor signaling pathway,
cell migration,
integrin-mediated signaling pathway,
epidermal growth factor receptor signaling pathway,
actin filament organization,
platelet-derived growth factor receptor signaling pathway,
cell adhesion,
insulin receptor signaling pathway,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 PTPSKTQQGLYQAPGPNPQFQ - 15592455
HTP
1.00
 - -
0.83
 - low
Y 228 VPTRVGQGYVYEAAQTEQDEY - 15592455
HTP
0.99
 - -
0.66
 - low
Y 238 YEAAQTEQDEYDTPRHLLAPG - 15592455
HTP
1.00
 - -
0.77
 - low
Y 331 PDGPLLREETYDVPPAFAKPK - 15592455
HTP
1.00
 - -
0.66
 - low
Y 366 PPDSPAAEDVYDVPPPAPDLY - 15592455
HTP
1.00
 - -
0.83
 - low
Y 376 YDVPPPAPDLYDVPPGLRRPG - 15592455
HTP
0.12
 - -
0.79
 - low
Y 414 ADGSVVDDGVYAVPPPAEREA - 15592455
HTP
1.00
 - -
0.77
 - low
Y 668 ENSEGGWMEDYDYVHLQGKEE FAK 11604500
LTP
1.00
 - -
0.49
 - low
Y 668 ENSEGGWMEDYDYVHLQGKEE SRC 11604500
LTP
1.00
 - -
0.49
 - low

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