Substrate: Bcl-2 (Apoptosis regulator Bcl-2)
Seq-ID: P10415 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13660   B2L11_MOUSE
MINT-51440   MK01_HUMAN
MINT-51443   PP2AA_HUMAN
MINT-56637   FKBP8_HUMAN
MINT-56639   MK08_HUMAN
MINT-58237   CANB1_HUMAN
MINT-6629252   B2L11_HUMAN
MINT-7235965   ASPP2_HUMAN
MINT-7712827   BECN1_HUMAN
MINT-7717145   NAF1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
protein homodimerization activity,
transcription activator activity,
protease binding,
BH3 domain binding,
sequence-specific DNA binding		 nuclear membrane,
integral to membrane,
mitochondrial outer membrane,
endoplasmic reticulum membrane		 negative regulation of cellular pH reduction,
positive regulation of cell growth,
regulation of protein homodimerization activity,
response to toxin,
anti-apoptosis,
humoral immune response,
defense response to virus,
release of cytochrome c from mitochondria,
response to drug,
regulation of mitochondrial membrane potential,
regulation of mitochondrial membrane permeability,
regulation of protein heterodimerization activity,
response to cytokine stimulus,
apoptosis in response to endoplasmic reticulum stress,
neuron apoptosis,
female pregnancy,
negative regulation of neuron apoptosis,
response to iron ion,
activation of pro-apoptotic gene products,
negative regulation of mitochondrial depolarization,
response to nicotine,
protein polyubiquitination,
B cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 56 PGIFSSQPGHTPHPAASRDPV - 12039864
LTP
0.17
 - -
0.77
 --
T 69 PAASRDPVARTSPLQTPAAPG MAPK_group 10567572
LTP
0.09
 MOD_ProDKin_1
 - -
0.75
 --
S 70 AASRDPVARTSPLQTPAAPGA MAPK_group 10567572
LTP
1.00
 MOD_ProDKin_1
 PIN1 WW -
0.75
 --
S 70 AASRDPVARTSPLQTPAAPGA MAPK8 10567572
LTP
1.00
 MOD_ProDKin_1
 PIN1 WW -
0.75
 --
T 74 DPVARTSPLQTPAAPGAAAGP - 12039864
LTP
0.75
 - -
0.68
 --
S 87 APGAAAGPALSPVPPVVHLTL MAPK_group 10567572
LTP
0.32
 MOD_ProDKin_1
 PIN1 WW -
0.43
 --
S 87 APGAAAGPALSPVPPVVHLTL MAPK8 10567572
LTP
0.32
 MOD_ProDKin_1
 PIN1 WW -
0.43
 --

Substrate: Bcl-2 (Apoptosis regulator Bcl-2)
Seq-ID: P10417 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
MINT-15650   BID_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
protein phosphatase 2A binding,
transcription activator activity,
transcription factor binding		 microsome,
myelin sheath,
integral to membrane,
endoplasmic reticulum membrane,
nuclear membrane,
mitochondrial outer membrane,
cytosol		 branching involved in ureteric bud morphogenesis,
melanocyte differentiation,
response to hydrogen peroxide,
positive regulation of smooth muscle cell migration,
positive regulation of peptidyl-serine phosphorylation,
protein amino acid dephosphorylation,
regulation of mitochondrial membrane potential,
endoplasmic reticulum calcium ion homeostasis,
actin filament organization,
positive regulation of neuron maturation,
positive regulation of skeletal muscle fiber development,
B cell homeostasis,
ossification,
negative regulation of cell migration,
regulation of glycoprotein biosynthetic process,
organ growth,
pigment granule organization,
B cell lineage commitment,
cell-cell adhesion,
mesenchymal cell development,
regulation of protein stability,
response to UV-B,
spleen development,
CD8-positive, alpha-beta T cell lineage commitment,
focal adhesion assembly,
positive regulation of melanocyte differentiation,
positive regulation of cell proliferation,
homeostasis of number of cells within a tissue,
regulation of cell-matrix adhesion,
melanin metabolic process,
male gonad development,
response to protein stimulus,
negative regulation of cell growth,
thymus development,
anti-apoptosis,
cell aging,
G1/S transition of mitotic cell cycle,
release of cytochrome c from mitochondria,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
peptidyl-serine phosphorylation,
negative regulation of ossification,
negative regulation of calcium ion transport into cytosol,
positive regulation of multicellular organism growth,
regulation of viral genome replication,
behavioral fear response,
neuron apoptosis,
regulation of protein localization,
cochlear nucleus development,
glomerulus development,
negative regulation of neuron apoptosis,
oxygen and reactive oxygen species metabolic process,
T cell homeostasis,
negative regulation of myeloid cell apoptosis,
axon regeneration,
developmental growth,
digestive tract morphogenesis,
negative regulation of mitotic cell cycle,
regulation of nitrogen utilization,
T cell differentiation in the thymus,
peptidyl-threonine phosphorylation,
lymphoid progenitor cell differentiation,
oocyte development,
ovarian follicle development,
renal system process,
ear development,
negative regulation of osteoblast proliferation,
gland morphogenesis,
hair follicle morphogenesis,
response to toxin,
cell growth,
response to drug,
positive regulation of catalytic activity,
post-embryonic development,
metanephros development,
response to cytokine stimulus,
negative regulation of retinal cell programmed cell death
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 70 AVHREMAARTSPLRPLVATAG MAPK8 11323415
LTP
0.08
 MOD_ProDKin_1
 - -
0.43
 - medium

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