Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P02340 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73224   LT_SV40
MINT-3979570   CHD3_HUMAN
MINT-3979604   P53_HUMAN
MINT-3979621   ZHX1_HUMAN
MINT-6540765   UBIQ_MOUSE
MINT-7261896   APBB1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
histone deacetylase regulator activity		 cytosol,
nucleolus,
endoplasmic reticulum,
replication fork,
mitochondrion		 chromosome organization,
negative regulation of fibroblast proliferation,
response to salt stress,
positive regulation of neuron apoptosis,
response to drug,
response to X-ray,
rRNA transcription,
response to tumor cell,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
multicellular organism growth,
transforming growth factor beta receptor signaling pathway,
double-strand break repair,
T cell lineage commitment,
nucleotide-excision repair,
negative regulation of neuroblast proliferation,
T cell differentiation in the thymus,
B cell lineage commitment,
negative regulation of transcription from RNA polymerase II promoter,
protein import into nucleus, translocation,
somitogenesis,
cellular response to UV,
central nervous system development,
negative regulation of apoptosis,
negative regulation of DNA replication,
T cell proliferation involved in immune response,
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,
negative regulation of cell growth,
negative regulation of transforming growth factor beta receptor signaling pathway,
activation of caspase activity by cytochrome c,
cell aging,
release of cytochrome c from mitochondria,
gastrulation,
in utero embryonic development,
positive regulation of histone deacetylation,
regulation of mitochondrial membrane permeability,
response to gamma radiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 312 KRALPTCTSASPPQKKKPLDG - 3006031
LTP
0.46
 - -
0.62
 - medium
S 363 TEESGDSRAHSSYLKTKKGQS - 9183006
LTP
0.44
 - -
0.74
 - medium
T 368 DSRAHSSYLKTKKGQSTSRHK - 9183006
LTP
0.00
 - -
0.75
 - medium
S 373 SSYLKTKKGQSTSRHKKTMVK - 9183006
LTP
0.00
 - -
0.70
 - medium
T 380 KGQSTSRHKKTMVKKVGPDSD - 9183006
LTP
0.00
 - -
0.81
 - medium
S 389 KTMVKKVGPDSD          - 3006031
LTP
0.00
 - -
0.54
 - medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 9   MEEPQSDPSVEPPLSQETF - 11875057
LTP
0.75
 - P53_TAD
0.94
 --
S 15 QSDPSVEPPLSQETFSDLWKL ATM 11875057
LTP
1.00
 MOD_PIKK_1
 - P53_TAD
0.73
 --
S 15 QSDPSVEPPLSQETFSDLWKL DNA-PK 10446957
LTP
1.00
 MOD_PIKK_1
 - P53_TAD
0.73
 --
T 18 PSVEPPLSQETFSDLWKLLPE CK1_group 10606744
LTP
1.00
 MOD_CK1_1
 - P53_TAD
0.64
 --
T 18 PSVEPPLSQETFSDLWKLLPE VRK1 15542844
LTP
1.00
 MOD_CK1_1
 - P53_TAD
0.64
 --
T 18 PSVEPPLSQETFSDLWKLLPE VRK1 10951572
LTP
1.00
 MOD_CK1_1
 - P53_TAD
0.64
 --
T 18 PSVEPPLSQETFSDLWKLLPE TTK 19332559
LTP
1.00
 MOD_CK1_1
 - P53_TAD
0.64
 --
S 20 VEPPLSQETFSDLWKLLPENN - 12111733
LTP
0.95
 - P53_TAD
0.60
 --
S 20 VEPPLSQETFSDLWKLLPENN - 10801407
LTP
0.95
 - P53_TAD
0.60
 --
S 20 VEPPLSQETFSDLWKLLPENN - 15489221
LTP
0.95
 - P53_TAD
0.60
 --
S 20 VEPPLSQETFSDLWKLLPENN - 15254178
LTP
0.95
 - P53_TAD
0.60
 --
S 20 VEPPLSQETFSDLWKLLPENN CHK2 17339337
LTP
0.95
 - P53_TAD
0.60
 --
S 20 VEPPLSQETFSDLWKLLPENN CHK1 17339337
LTP
0.95
 - P53_TAD
0.60
 --
S 20 VEPPLSQETFSDLWKLLPENN DAPK1 17339337
LTP
0.95
 - P53_TAD
0.60
 --
S 33 WKLLPENNVLSPLPSQAMDDL GSK-3_group 11483158
LTP
0.88
 MOD_GSK3_1
 PIN1 WW -
0.56
 --
S 33 WKLLPENNVLSPLPSQAMDDL CDK_group 9372954
LTP
0.88
 MOD_GSK3_1
 PIN1 WW -
0.56
 --
S 33 WKLLPENNVLSPLPSQAMDDL CDK7 9372954
LTP
0.88
 MOD_GSK3_1
 PIN1 WW -
0.56
 --
S 37 PENNVLSPLPSQAMDDLMLSP DNA-PK 11483158
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --
S 37 PENNVLSPLPSQAMDDLMLSP DNA-PK 15381073
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --
S 37 PENNVLSPLPSQAMDDLMLSP DNA-PK 12959929
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --
S 37 PENNVLSPLPSQAMDDLMLSP DNA-PK
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --
S 37 PENNVLSPLPSQAMDDLMLSP MAPKAPK5 17254968
LTP
0.47
 MOD_PIKK_1
 - -
0.65
 --
S 46 PSQAMDDLMLSPDDIEQWFTE - 11875057
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --
S 46 PSQAMDDLMLSPDDIEQWFTE HIPK2 16729035
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --
S 46 PSQAMDDLMLSPDDIEQWFTE ATM 20123963
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --
S 46 PSQAMDDLMLSPDDIEQWFTE DYRK2 17349958
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --
S 46 PSQAMDDLMLSPDDIEQWFTE DYRK2 19965871
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --
S 46 PSQAMDDLMLSPDDIEQWFTE HIPK2 11780126
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --
T 55 LSPDDIEQWFTEDPGPDEAPR MAPK_group 11409876
LTP
0.00
 - -
0.82
 --
S 99 PSWPLSSSVPSQKTYQGSYGF - 17525332
HTP
1.00
 - P53
0.44
 3D08 58.20%
S 215 YLDDRNTFRHSVVVPYEPPEV Aurora A 15469940
LTP
1.00
 - P53
0.47
 3D08 6.56%
S 315 KRALPNNTSSSPQPKKKPLDG - 1956339
LTP
0.95
 PIN1 WW -
0.84
 --
S 315 KRALPNNTSSSPQPKKKPLDG Aurora A 14702041
LTP
0.95
 PIN1 WW -
0.84
 --
S 315 KRALPNNTSSSPQPKKKPLDG - 17287340
HTP
0.95
 PIN1 WW -
0.84
 --
S 371 GSRAHSSHLKSKKGQSTSRHK CDK7 9315650
LTP
0.66
 - -
0.88
 --
S 376 SSHLKSKKGQSTSRHKKLMFK CDK7 9315650
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.81
 --
S 378 HLKSKKGQSTSRHKKLMFKTE CDK7 9315650
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.82
 --
S 392 KLMFKTEGPDSD          - 10747897
LTP
0.31
 - -
0.56
 --
S 392 KLMFKTEGPDSD          - 10348343
LTP
0.31
 - -
0.56
 --
S 392 KLMFKTEGPDSD          CDK7 9315650
LTP
0.31
 - -
0.56
 --
S 392 KLMFKTEGPDSD          - 16083285
HTP
0.31
 - -
0.56
 --

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P10361 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
RNA polymerase II transcription factor activity,
ubiquitin protein ligase binding,
DNA strand annealing activity,
copper ion binding,
ATP binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
transcription repressor activity,
sequence-specific DNA binding,
protein C-terminus binding		 cytosol,
transcription factor complex,
nucleolus,
soluble fraction,
endoplasmic reticulum,
mitochondrion,
chromatin		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
response to amino acid stimulus,
response to oxidative stress,
response to drug,
response to vitamin B3,
cell cycle,
positive regulation of apoptosis,
negative regulation of smooth muscle cell proliferation,
response to cytokine stimulus,
response to X-ray,
response to tumor cell,
regulation of intracellular pH,
response to caffeine,
nucleotide-excision repair,
response to retinoic acid,
wound healing,
multicellular organismal development,
response to hyperoxia,
positive regulation of leukocyte migration,
response to metal ion,
response to UV,
transcription,
negative regulation of cell growth,
positive regulation of cell cycle,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 6      MEDSQSDMSIELPLSQ CK1_group 7862459
LTP
0.18
 MOD_CK1_1
 - P53_TAD
0.73
 - medium
S 9   MEDSQSDMSIELPLSQETF CK1_group 7862459
LTP
0.75
 MOD_CK1_1
 - P53_TAD
0.65
 - medium
S 15 QSDMSIELPLSQETFSCLWKL DNA-PK 7862459
LTP
1.00
 MOD_PIKK_1
 - P53_TAD
0.35
 - medium
S 39 DDILPTTATGSPNSMEDLFLP - 7862459
LTP
0.75
 - -
0.59
 - medium
S 313 KRALPTSTSSSPQQKKKPLDG CDK1 7862459
LTP
0.95
 - -
0.78
 - medium

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