Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate: tau (Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau))

Seq-ID: P10636 [Homo sapiens]

Download: fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):
[show]

MINT-49642   AATF_HUMAN
MINT-74874   KS6B1_HUMAN
MINT-3390085   KC1D_RAT
MINT-3974182   CDK5_HUMAN
MINT-3974216   GSK3B_HUMAN
MINT-7148384   EAA2_HUMAN

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

apolipoprotein E binding,
SH3 domain binding,
lipoprotein binding,
identical protein binding,
structural constituent of cytoskeleton,
enzyme binding,
microtubule binding plasma membrane,
cytosol,
microtubule associated complex,
tubulin complex,
axon,
growth cone,
microtubule positive regulation of microtubule polymerization,
superior temporal gyrus development,
negative regulation of microtubule depolymerization,
positive regulation of axon extension,
microtubule cytoskeleton organization

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

S 519 GDRSGYSSPGSPGTPGSRSRT CDK_group 12226093
LTP

1.00
- -
0.95
- medium

T 522 SGYSSPGSPGTPGSRSRTPSL CDK_group 12226093
LTP

1.00
- -
0.95
- medium

T 529 SPGTPGSRSRTPSLPTPPTRE CDK_group 11181841
LTP

0.84
- -
0.97
- medium

T 529 SPGTPGSRSRTPSLPTPPTRE CDK_group 2387894
LTP

0.84
- -
0.97
- medium

S 531 GTPGSRSRTPSLPTPPTREPK - 12387894
LTP

0.54
- -
0.97
- medium

S 531 GTPGSRSRTPSLPTPPTREPK PKA_group 12435421
LTP

0.54
- -
0.97
- medium

S 531 GTPGSRSRTPSLPTPPTREPK - 9832145
LTP

0.54
- -
0.97
- medium

T 534 GSRSRTPSLPTPPTREPKKVA CDK_group 11181841
LTP

1.00
- -
0.94
- medium

T 534 GSRSRTPSLPTPPTREPKKVA CDK_group 2387894
LTP

1.00
- -
0.94
- medium

T 548 REPKKVAVVRTPPKSPSSAKS CDK_group 12387894
LTP

1.00
MOD_GSK3_1
- -
0.89
- medium

T 548 REPKKVAVVRTPPKSPSSAKS GSK-3_beta 9565682
LTP

1.00
MOD_GSK3_1
- -
0.89
- medium

T 548 REPKKVAVVRTPPKSPSSAKS CDK_group 9735171
LTP

1.00
MOD_GSK3_1
- -
0.89
- medium

T 548 REPKKVAVVRTPPKSPSSAKS - 17287340
HTP

1.00
MOD_GSK3_1
- -
0.89
- medium

S 552 KVAVVRTPPKSPSSAKSRLQT CDK_group 12387894
LTP

1.00
MOD_GSK3_1
- -
0.87
- medium

S 552 KVAVVRTPPKSPSSAKSRLQT GSK-3_beta 9565682
LTP

1.00
MOD_GSK3_1
- -
0.87
- medium

S 552 KVAVVRTPPKSPSSAKSRLQT - 17287340
HTP

1.00
MOD_GSK3_1
- -
0.87
- medium

S 575 VPMPDLKNVKSKIGSTENLKH GSK-3_beta 12714590
LTP

1.00
MOD_GSK3_1
- Tubulin-binding
0.81
- medium

S 579 DLKNVKSKIGSTENLKHQPGG GSK-3_beta 12714590
LTP

1.00
MOD_GSK3_1
- Tubulin-binding
0.83
- medium

T 690 VPGGGNKKIETHKLTFRENAK CDK_group 12387894
LTP

0.80
- -
0.61
- medium

S 713 TDHGAEIVYKSPVVSGDTSPR CDK_group 12387894
LTP

1.00
MOD_GSK3_1
- -
0.57
- medium

S 713 TDHGAEIVYKSPVVSGDTSPR GSK-3_beta 9565682
LTP

1.00
MOD_GSK3_1
- -
0.57
- medium

S 713 TDHGAEIVYKSPVVSGDTSPR CDK_group 11181841
LTP

1.00
MOD_GSK3_1
- -
0.57
- medium

S 721 YKSPVVSGDTSPRHLSNVSST CDK_group 12387894
LTP

1.00
MOD_GSK3_1
- -
0.61
- medium

S 721 YKSPVVSGDTSPRHLSNVSST GSK-3_beta 9565682
LTP

1.00
MOD_GSK3_1
- -
0.61
- medium

S 721 YKSPVVSGDTSPRHLSNVSST CDK_group 11181841
LTP

1.00
MOD_GSK3_1
- -
0.61
- medium

Substrate: tau (Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau))

Seq-ID: P10636-8 [Homo sapiens]

Download: fasta csv

Interaction Network(s): -

External Source(s):

MINT Interaction(s):
[show]

MINT-74872   KS6B1_HUMAN
MINT-6174455   DCTN1_HUMAN

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

apolipoprotein E binding,
SH3 domain binding,
lipoprotein binding,
identical protein binding,
structural constituent of cytoskeleton,
enzyme binding,
microtubule binding plasma membrane,
cytosol,
microtubule associated complex,
tubulin complex,
axon,
growth cone,
microtubule positive regulation of microtubule polymerization,
superior temporal gyrus development,
negative regulation of microtubule depolymerization,
positive regulation of axon extension,
microtubule cytoskeleton organization

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

S 237 AVVRTPPKSPSSAKSRLQTAP PHK_group 8999860
LTP

0.42
- -
0.89
- medium

S 262 DLKNVKSKIGSTENLKHQPGG PHK_group 8999860
LTP

1.00
- Tubulin-binding
0.83
- medium

S 285 VQIINKKLDLSNVQSKCGSKD PHK_group 8999860
LTP

0.91
- Tubulin-binding
0.55
- medium

S 305 DNIKHVPGGGSVQIVYKPVDL PHK_group 8999860
LTP

0.21
- Tubulin-binding
0.52
- medium

S 352 EKLDFKDRVQSKIGSLDNITH PHK_group 8999860
LTP

0.77
- Tubulin-binding
0.46
- medium

Substrate: tau (Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau))

Seq-ID: P10637 [Mus musculus]

Download: fasta csv

Interaction Network(s): -

External Source(s):

MINT Interaction(s):
MINT-3974239   CDK5_HUMAN

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

microtubule binding plasma membrane,
cytosol,
tubulin complex,
cilium axoneme,
axon,
growth cone,
microtubule positive regulation of microtubule polymerization,
negative regulation of microtubule depolymerization,
positive regulation of axon extension,
microtubule cytoskeleton organization

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

T 100 ITAEEAGIGDTPNQEDQAAGH - 14642273
LTP

0.87
- -
0.97
- medium

T 100 ITAEEAGIGDTPNQEDQAAGH - 17114649
HTP

0.87
- -
0.97
- medium

T 467 TSNATRIPAKTTPSPKTPPGS - 14642273
LTP

0.76
- -
0.96
- medium

S 470 ATRIPAKTTPSPKTPPGSGEP - 17114649
HTP

0.11
- -
0.96
- medium

T 473 IPAKTTPSPKTPPGSGEPPKS - 17114649
HTP

0.76
- -
0.97
- medium

Y 489 EPPKSGERSGYSSPGSPGTPG - 17114649
HTP

0.50
- -
0.96
- medium

S 490 PPKSGERSGYSSPGSPGTPGS - 15572359
HTP

0.50
- -
0.96
- medium

S 491 PKSGERSGYSSPGSPGTPGSR - 15572359
HTP

0.50
- -
0.96
- medium

S 491 PKSGERSGYSSPGSPGTPGSR - 17242355
HTP

0.50
- -
0.96
- medium

S 494 GERSGYSSPGSPGTPGSRSRT - 15572359
HTP

0.50
- -
0.95
- medium

S 494 GERSGYSSPGSPGTPGSRSRT - 17114649
HTP

0.50
- -
0.95
- medium

T 497 SGYSSPGSPGTPGSRSRTPSL - 17114649
HTP

1.00
- -
0.95
- medium

T 523 REPKKVAVVRTPPKSPSASKS - 16452087
HTP

0.78
- -
0.89
- medium

S 527 KVAVVRTPPKSPSASKSRLQT - 16452087
HTP

1.00
- -
0.86
- medium

S 688 TDHGAEIVYKSPVVSGDTSPR - 15572359
HTP

0.74
- -
0.57
- medium

S 688 TDHGAEIVYKSPVVSGDTSPR - 17242355
HTP

0.74
- -
0.57
- medium

S 688 TDHGAEIVYKSPVVSGDTSPR - 17114649
HTP

0.74
- -
0.57
- medium

S 692 AEIVYKSPVVSGDTSPRHLSN - 15572359
HTP

0.78
- -
0.53
- medium

S 692 AEIVYKSPVVSGDTSPRHLSN - 17242355
HTP

0.78
- -
0.53
- medium

S 692 AEIVYKSPVVSGDTSPRHLSN - 17114649
HTP

0.78
- -
0.53
- medium

T 695 VYKSPVVSGDTSPRHLSNVSS - 15572359
HTP

0.55
- -
0.59
- medium

T 695 VYKSPVVSGDTSPRHLSNVSS - 17114649
HTP

0.55
- -
0.59
- medium

S 696 YKSPVVSGDTSPRHLSNVSST - 15345747
HTP

0.78
- -
0.61
- medium

S 696 YKSPVVSGDTSPRHLSNVSST - 15572359
HTP

0.78
- -
0.61
- medium

S 696 YKSPVVSGDTSPRHLSNVSST - 17242355
HTP

0.78
- -
0.61
- medium

S 701 VSGDTSPRHLSNVSSTGSIDM - 15345747
HTP

0.78
- -
0.66
- medium

S 701 VSGDTSPRHLSNVSSTGSIDM - 15572359
HTP

0.78
- -
0.66
- medium

S 704 DTSPRHLSNVSSTGSIDMVDS - 15572359
HTP

0.78
- -
0.67
- medium

T 706 SPRHLSNVSSTGSIDMVDSPQ - 15345747
HTP

0.28
- -
0.64
- medium

T 706 SPRHLSNVSSTGSIDMVDSPQ - 15572359
HTP

0.28
- -
0.64
- medium

S 708 RHLSNVSSTGSIDMVDSPQLA - 15345747
HTP

1.00
- -
0.59
- medium

Substrate: tau (Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau))

Seq-ID: P19332 [Rattus norvegicus]

Download: fasta csv

Interaction Network(s): -

External Source(s):

MINT Interaction(s): -

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

protein kinase binding,
protein domain specific binding,
microtubule binding plasma membrane,
cytosol,
tubulin complex,
microtubule,
axonal growth cone apoptosis,
response to nutrient,
positive regulation of microtubule polymerization,
negative regulation of microtubule depolymerization,
positive regulation of axon extension,
response to organic substance,
microtubule cytoskeleton organization,
neuron differentiation

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

T 172 LREATHQPLGTRPEDVERSHP - 8245007
LTP

0.34
- -
0.94
- high

S 191 HPASELLWQESPQKEAWGKDR - 8245007
LTP

0.00
- -
0.79
- high

S 224 MDESSQESPPSQASLAPGTAT - 8245007
LTP

0.85
- -
0.96
- high

S 227 SSQESPPSQASLAPGTATPQA - 8245007
LTP

0.85
- -
0.96
- high

S 388 TGNDEKKAKTSTPSCAKTPSN - 8245007
LTP

0.61
- -
0.86
- high

S 509 PPKSGERSGYSSPGSPGTPGS - 8245007
LTP

0.77
- -
0.95
- high

S 513 GERSGYSSPGSPGTPGSRSRT - 8245007
LTP

0.61
- -
0.95
- high

S 711 AEIVYKSPVVSGDTSPRHLSN - 8245007
LTP

0.77
- -
0.53
- high

S 715 YKSPVVSGDTSPRHLSNVSST - 8245007
LTP

0.81
- -
0.61
- high

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	519	GDRSGYSSPGSPGTPGSRSRT	CDK_group	12226093	LTP	1.00		-	-	0.95	-	medium
T	522	SGYSSPGSPGTPGSRSRTPSL	CDK_group	12226093	LTP	1.00		-	-	0.95	-	medium
T	529	SPGTPGSRSRTPSLPTPPTRE	CDK_group	11181841	LTP	0.84		-	-	0.97	-	medium
T	529	SPGTPGSRSRTPSLPTPPTRE	CDK_group	2387894	LTP	0.84		-	-	0.97	-	medium
S	531	GTPGSRSRTPSLPTPPTREPK	-	12387894	LTP	0.54		-	-	0.97	-	medium
S	531	GTPGSRSRTPSLPTPPTREPK	PKA_group	12435421	LTP	0.54		-	-	0.97	-	medium
S	531	GTPGSRSRTPSLPTPPTREPK	-	9832145	LTP	0.54		-	-	0.97	-	medium
T	534	GSRSRTPSLPTPPTREPKKVA	CDK_group	11181841	LTP	1.00		-	-	0.94	-	medium
T	534	GSRSRTPSLPTPPTREPKKVA	CDK_group	2387894	LTP	1.00		-	-	0.94	-	medium
T	548	REPKKVAVVRTPPKSPSSAKS	CDK_group	12387894	LTP	1.00	MOD_GSK3_1	-	-	0.89	-	medium
T	548	REPKKVAVVRTPPKSPSSAKS	GSK-3_beta	9565682	LTP	1.00	MOD_GSK3_1	-	-	0.89	-	medium
T	548	REPKKVAVVRTPPKSPSSAKS	CDK_group	9735171	LTP	1.00	MOD_GSK3_1	-	-	0.89	-	medium
T	548	REPKKVAVVRTPPKSPSSAKS	-	17287340	HTP	1.00	MOD_GSK3_1	-	-	0.89	-	medium
S	552	KVAVVRTPPKSPSSAKSRLQT	CDK_group	12387894	LTP	1.00	MOD_GSK3_1	-	-	0.87	-	medium
S	552	KVAVVRTPPKSPSSAKSRLQT	GSK-3_beta	9565682	LTP	1.00	MOD_GSK3_1	-	-	0.87	-	medium
S	552	KVAVVRTPPKSPSSAKSRLQT	-	17287340	HTP	1.00	MOD_GSK3_1	-	-	0.87	-	medium
S	575	VPMPDLKNVKSKIGSTENLKH	GSK-3_beta	12714590	LTP	1.00	MOD_GSK3_1	-	Tubulin-binding	0.81	-	medium
S	579	DLKNVKSKIGSTENLKHQPGG	GSK-3_beta	12714590	LTP	1.00	MOD_GSK3_1	-	Tubulin-binding	0.83	-	medium
T	690	VPGGGNKKIETHKLTFRENAK	CDK_group	12387894	LTP	0.80		-	-	0.61	-	medium
S	713	TDHGAEIVYKSPVVSGDTSPR	CDK_group	12387894	LTP	1.00	MOD_GSK3_1	-	-	0.57	-	medium
S	713	TDHGAEIVYKSPVVSGDTSPR	GSK-3_beta	9565682	LTP	1.00	MOD_GSK3_1	-	-	0.57	-	medium
S	713	TDHGAEIVYKSPVVSGDTSPR	CDK_group	11181841	LTP	1.00	MOD_GSK3_1	-	-	0.57	-	medium
S	721	YKSPVVSGDTSPRHLSNVSST	CDK_group	12387894	LTP	1.00	MOD_GSK3_1	-	-	0.61	-	medium
S	721	YKSPVVSGDTSPRHLSNVSST	GSK-3_beta	9565682	LTP	1.00	MOD_GSK3_1	-	-	0.61	-	medium
S	721	YKSPVVSGDTSPRHLSNVSST	CDK_group	11181841	LTP	1.00	MOD_GSK3_1	-	-	0.61	-	medium

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	237	AVVRTPPKSPSSAKSRLQTAP	PHK_group	8999860	LTP	0.42	-	-	0.89	-	medium
S	262	DLKNVKSKIGSTENLKHQPGG	PHK_group	8999860	LTP	1.00	-	Tubulin-binding	0.83	-	medium
S	285	VQIINKKLDLSNVQSKCGSKD	PHK_group	8999860	LTP	0.91	-	Tubulin-binding	0.55	-	medium
S	305	DNIKHVPGGGSVQIVYKPVDL	PHK_group	8999860	LTP	0.21	-	Tubulin-binding	0.52	-	medium
S	352	EKLDFKDRVQSKIGSLDNITH	PHK_group	8999860	LTP	0.77	-	Tubulin-binding	0.46	-	medium

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	100	ITAEEAGIGDTPNQEDQAAGH	-	14642273	LTP	0.87	-	-	0.97	-	medium
T	100	ITAEEAGIGDTPNQEDQAAGH	-	17114649	HTP	0.87	-	-	0.97	-	medium
T	467	TSNATRIPAKTTPSPKTPPGS	-	14642273	LTP	0.76	-	-	0.96	-	medium
S	470	ATRIPAKTTPSPKTPPGSGEP	-	17114649	HTP	0.11	-	-	0.96	-	medium
T	473	IPAKTTPSPKTPPGSGEPPKS	-	17114649	HTP	0.76	-	-	0.97	-	medium
Y	489	EPPKSGERSGYSSPGSPGTPG	-	17114649	HTP	0.50	-	-	0.96	-	medium
S	490	PPKSGERSGYSSPGSPGTPGS	-	15572359	HTP	0.50	-	-	0.96	-	medium
S	491	PKSGERSGYSSPGSPGTPGSR	-	15572359	HTP	0.50	-	-	0.96	-	medium
S	491	PKSGERSGYSSPGSPGTPGSR	-	17242355	HTP	0.50	-	-	0.96	-	medium
S	494	GERSGYSSPGSPGTPGSRSRT	-	15572359	HTP	0.50	-	-	0.95	-	medium
S	494	GERSGYSSPGSPGTPGSRSRT	-	17114649	HTP	0.50	-	-	0.95	-	medium
T	497	SGYSSPGSPGTPGSRSRTPSL	-	17114649	HTP	1.00	-	-	0.95	-	medium
T	523	REPKKVAVVRTPPKSPSASKS	-	16452087	HTP	0.78	-	-	0.89	-	medium
S	527	KVAVVRTPPKSPSASKSRLQT	-	16452087	HTP	1.00	-	-	0.86	-	medium
S	688	TDHGAEIVYKSPVVSGDTSPR	-	15572359	HTP	0.74	-	-	0.57	-	medium
S	688	TDHGAEIVYKSPVVSGDTSPR	-	17242355	HTP	0.74	-	-	0.57	-	medium
S	688	TDHGAEIVYKSPVVSGDTSPR	-	17114649	HTP	0.74	-	-	0.57	-	medium
S	692	AEIVYKSPVVSGDTSPRHLSN	-	15572359	HTP	0.78	-	-	0.53	-	medium
S	692	AEIVYKSPVVSGDTSPRHLSN	-	17242355	HTP	0.78	-	-	0.53	-	medium
S	692	AEIVYKSPVVSGDTSPRHLSN	-	17114649	HTP	0.78	-	-	0.53	-	medium
T	695	VYKSPVVSGDTSPRHLSNVSS	-	15572359	HTP	0.55	-	-	0.59	-	medium
T	695	VYKSPVVSGDTSPRHLSNVSS	-	17114649	HTP	0.55	-	-	0.59	-	medium
S	696	YKSPVVSGDTSPRHLSNVSST	-	15345747	HTP	0.78	-	-	0.61	-	medium
S	696	YKSPVVSGDTSPRHLSNVSST	-	15572359	HTP	0.78	-	-	0.61	-	medium
S	696	YKSPVVSGDTSPRHLSNVSST	-	17242355	HTP	0.78	-	-	0.61	-	medium
S	701	VSGDTSPRHLSNVSSTGSIDM	-	15345747	HTP	0.78	-	-	0.66	-	medium
S	701	VSGDTSPRHLSNVSSTGSIDM	-	15572359	HTP	0.78	-	-	0.66	-	medium
S	704	DTSPRHLSNVSSTGSIDMVDS	-	15572359	HTP	0.78	-	-	0.67	-	medium
T	706	SPRHLSNVSSTGSIDMVDSPQ	-	15345747	HTP	0.28	-	-	0.64	-	medium
T	706	SPRHLSNVSSTGSIDMVDSPQ	-	15572359	HTP	0.28	-	-	0.64	-	medium
S	708	RHLSNVSSTGSIDMVDSPQLA	-	15345747	HTP	1.00	-	-	0.59	-	medium

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	172	LREATHQPLGTRPEDVERSHP	-	8245007	LTP	0.34	-	-	0.94	-	high
S	191	HPASELLWQESPQKEAWGKDR	-	8245007	LTP	0.00	-	-	0.79	-	high
S	224	MDESSQESPPSQASLAPGTAT	-	8245007	LTP	0.85	-	-	0.96	-	high
S	227	SSQESPPSQASLAPGTATPQA	-	8245007	LTP	0.85	-	-	0.96	-	high
S	388	TGNDEKKAKTSTPSCAKTPSN	-	8245007	LTP	0.61	-	-	0.86	-	high
S	509	PPKSGERSGYSSPGSPGTPGS	-	8245007	LTP	0.77	-	-	0.95	-	high
S	513	GERSGYSSPGSPGTPGSRSRT	-	8245007	LTP	0.61	-	-	0.95	-	high
S	711	AEIVYKSPVVSGDTSPRHLSN	-	8245007	LTP	0.77	-	-	0.53	-	high
S	715	YKSPVVSGDTSPRHLSNVSST	-	8245007	LTP	0.81	-	-	0.61	-	high