Substrate: APC (Adhesion molecule)
Seq-ID: P25054 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1780719   DLG4_MOUSE
MINT-3296068   1433Z_HUMAN
MINT-3975353   1433S_HUMAN
MINT-4508229   CTNB1_HUMAN
MINT-6732416   SCRIB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
microtubule plus-end binding,
protein kinase regulator activity,
protein kinase binding,
beta-catenin binding,
gamma-catenin binding		 centrosome,
Axin-APC-beta-catenin-GSK3B complex,
beta-catenin destruction complex,
cytosol,
lateral plasma membrane,
kinetochore,
adherens junction,
nucleus,
tight junction		 negative regulation of cyclin-dependent protein kinase activity,
positive regulation of protein catabolic process,
protein complex assembly,
positive regulation of cell migration,
positive regulation of pseudopodium assembly,
cell cycle arrest,
cytokinesis after mitosis,
negative regulation of canonical Wnt receptor signaling pathway,
positive regulation of apoptosis,
canonical Wnt receptor signaling pathway,
negative regulation of microtubule depolymerization,
regulation of attachment of spindle microtubules to kinetochore,
response to DNA damage stimulus,
cell adhesion,
tight junction assembly,
mitotic cell cycle spindle assembly checkpoint
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 780 SETFDNIDNLSPKASHRSKQR - 18669648
HTP
1.00
 - -
0.72
 - medium
S 1042 SDEQLNSGRQSPSQNERWARP - 18669648
HTP
1.00
 - -
0.78
 - medium
S 1279 ICFSRCSSLSSLSSAEDEIGC CK1_group 11487578
LTP
1.00
 MOD_CK1_1
 - APC_crr
0.37
 - medium
S 1279 ICFSRCSSLSSLSSAEDEIGC CK1_epsilon 11487578
LTP
1.00
 MOD_CK1_1
 - APC_crr
0.37
 - medium
S 1360 KAVEFSSGAKSPSKSGAQTPK - 18669648
HTP
1.00
 - -
0.80
 - medium
S 1392 LMFSRCTSVSSLDSFESRSIA CK1_group 11487578
LTP
1.00
 MOD_CK1_1
 - APC_crr
0.48
 - medium
S 1392 LMFSRCTSVSSLDSFESRSIA CK1_epsilon 11487578
LTP
1.00
 MOD_CK1_1
 - APC_crr
0.48
 - medium
T 1438 GQTMPPSRSKTPPPPPQTAQT - 18669648
HTP
1.00
 - -
0.98
 - medium
S 1861 GTPYCFSRNDSLSSLDFDDDD - 17081983
HTP
1.00
 - APC_crr
0.48
 - medium
S 1861 GTPYCFSRNDSLSSLDFDDDD - 18669648
HTP
1.00
 - APC_crr
0.48
 - medium
S 1863 PYCFSRNDSLSSLDFDDDDVD - 17081983
HTP
1.00
 - APC_crr
0.49
 - medium
S 1863 PYCFSRNDSLSSLDFDDDDVD - 18669648
HTP
1.00
 - APC_crr
0.49
 - medium
S 1864 YCFSRNDSLSSLDFDDDDVDL - 17081983
HTP
0.17
 - APC_crr
0.50
 - medium
S 1864 YCFSRNDSLSSLDFDDDDVDL - 18669648
HTP
0.17
 - APC_crr
0.50
 - medium
S 2034 NSSLSSLSIDSEDDLLQECIS - 11689703
LTP
1.00
 - SAMP
0.46
 - medium
S 2054 SSAMPKKKKPSRLKGDNEKHS PKA_group 11050185
LTP
0.11
 MOD_PKA_1
 - -
0.81
 - medium
S 2088 LDLKDIQRPDSEHGLSPDSEN - 18669648
HTP
0.15
 - -
0.74
 - medium
S 2093 IQRPDSEHGLSPDSENFDWKA - 18669648
HTP
0.93
 - -
0.68
 - medium
S 2096 PDSEHGLSPDSENFDWKAIQE - 18669648
HTP
0.15
 - -
0.65
 - medium
S 2125 LHQAAAAACLSRQASSDSDSI - 18220336
HTP
1.00
 - -
0.48
 - medium
S 2129 AAAACLSRQASSDSDSILSLK - 18669648
HTP
1.00
 - -
0.44
 - medium
S 2130 AAACLSRQASSDSDSILSLKS - 18669648
HTP
1.00
 - -
0.42
 - medium
S 2143 DSILSLKSGISLGSPFHLTPD - 18669648
HTP
1.00
 - -
0.48
 - medium
T 2151 GISLGSPFHLTPDQEEKPFTS - 18669648
HTP
0.08
 - -
0.69
 - medium
S 2260 GPPLKTPASKSPSEGQTATTS - 18669648
HTP
1.00
 - APC_basic
0.94
 - medium
S 2270 SPSEGQTATTSPRGAKPSVKS - 18669648
HTP
1.00
 - APC_basic
0.92
 - medium
S 2283 GAKPSVKSELSPVARQTSQIG - 16964243
HTP
0.06
 - APC_basic
0.86
 - medium
S 2283 GAKPSVKSELSPVARQTSQIG - 18669648
HTP
0.06
 - APC_basic
0.86
 - medium
S 2398 ASSIPRSESASKGLNQMNNGN - 17081983
HTP
0.17
 - APC_basic
0.90
 - medium
S 2464 RKLEESASFESLSPSSRPASP - 18669648
HTP
0.23
 - APC_basic
0.79
 - medium
S 2469 SASFESLSPSSRPASPTRSQA - 18669648
HTP
0.95
 - APC_basic
0.85
 - medium
S 2473 ESLSPSSRPASPTRSQAQTPV - 18669648
HTP
1.00
 - APC_basic
0.88
 - medium
S 2533 AKRHDIARSHSESPSRLPINR - 18669648
HTP
1.00
 - APC_basic
0.82
 - medium
S 2535 RHDIARSHSESPSRLPINRSG - 18669648
HTP
1.00
 - APC_basic
0.78
 - medium
S 2671 IEDCPINNPRSGRSPTGNTPP - 18220336
HTP
1.00
 - EB1_binding
0.86
 - medium
S 2671 IEDCPINNPRSGRSPTGNTPP - 18669648
HTP
1.00
 - EB1_binding
0.86
 - medium
S 2674 CPINNPRSGRSPTGNTPPVID - 18220336
HTP
1.00
 - EB1_binding
0.88
 - medium
S 2674 CPINNPRSGRSPTGNTPPVID - 18669648
HTP
1.00
 - EB1_binding
0.88
 - medium
T 2676 INNPRSGRSPTGNTPPVIDSV - 18220336
HTP
1.00
 - EB1_binding
0.89
 - medium
T 2676 INNPRSGRSPTGNTPPVIDSV - 18669648
HTP
1.00
 - EB1_binding
0.89
 - medium
T 2679 PRSGRSPTGNTPPVIDSVSEK - 18220336
HTP
1.00
 - EB1_binding
0.89
 - medium
T 2679 PRSGRSPTGNTPPVIDSVSEK - 18669648
HTP
1.00
 - EB1_binding
0.89
 - medium
S 2789 ARVTPFNYNPSPRKSSADSTS - 18220336
HTP
1.00
 - EB1_binding
0.84
 - medium
S 2789 ARVTPFNYNPSPRKSSADSTS - 18669648
HTP
1.00
 - EB1_binding
0.84
 - medium
S 2835 SSGTQSPKRHSGSYLVTSV   - 18220336
HTP
1.00
 - EB1_binding
0.81
 - medium
S 2837 GTQSPKRHSGSYLVTSV     - 18220336
HTP
1.00
 - EB1_binding
0.79
 - medium
Y 2838 TQSPKRHSGSYLVTSV      - 18220336
HTP
1.00
 - EB1_binding
0.78
 - medium

Substrate: APC (Adhesion molecule)
Seq-ID: Q61315 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-catenin binding,
microtubule plus-end binding,
protein kinase regulator activity		 beta-catenin destruction complex,
cell projection membrane,
kinetochore,
nucleus,
cytoplasmic microtubule,
growth cone,
axon part,
centrosome		 chromosome organization,
dorsal/ventral pattern formation,
negative regulation of cyclin-dependent protein kinase activity,
positive regulation of protein catabolic process,
negative regulation of odontogenesis,
positive regulation of cell migration,
regulation of osteoclast differentiation,
cell cycle arrest,
hair follicle development,
kidney development,
positive regulation of apoptosis,
positive regulation of epithelial cell differentiation,
negative regulation of MAPKKK cascade,
negative regulation of microtubule depolymerization,
retina development in camera-type eye,
regulation of attachment of spindle microtubules to kinetochore,
anterior/posterior pattern formation,
mitotic metaphase/anaphase transition,
axonogenesis,
somatic stem cell maintenance,
axis specification,
muscle cell homeostasis,
negative regulation of epithelial cell proliferation involved in prostate gland development,
response to DNA damage stimulus,
positive regulation of cell division,
T cell differentiation in the thymus,
skin development,
regulation of nitrogen compound metabolic process,
protein complex assembly,
negative regulation of apoptosis,
thymus development,
proximal/distal pattern formation,
cell migration,
cytokinesis after mitosis,
regulation of osteoblast differentiation,
positive regulation of cell adhesion,
positive regulation of microtubule polymerization,
canonical Wnt receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 1036 SLKYSDEQLNSGRQSPSQNER - 17242355
HTP
1.00
 - -
0.75
 - medium
S 1370 PSKSGAQTPKSPPEHYVQETP - 17114649
HTP
1.00
 - APC_crr
0.87
 - medium
S 2674 CPINNPRSGRSPTGNTPPVID - 17114649
HTP
1.00
 - EB1_binding
0.89
 - medium
S 2713 THGKQSVGSGSPVQTVGLETR - 17114649
HTP
0.16
 - EB1_binding
0.79
 - medium

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