Substrate: PCSK9
Seq-ID: Q8NBP7 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
apolipoprotein receptor binding,
very-low-density lipoprotein receptor binding,
identical protein binding,
low-density lipoprotein receptor binding,
serine-type endopeptidase activity		 late endosome,
extrinsic to external side of plasma membrane,
lysosome,
extracellular space,
perinuclear region of cytoplasm		 positive regulation of receptor internalization,
cellular response to starvation,
negative regulation of catalytic activity,
proteolysis,
positive regulation of neuron apoptosis,
cholesterol homeostasis,
kidney development,
regulation of receptor activity,
liver development,
cellular response to insulin stimulus,
lysosomal transport,
cholesterol metabolic process,
negative regulation of low-density lipoprotein particle clearance,
protein autoprocessing,
low-density lipoprotein receptor catabolic process,
negative regulation of receptor recycling,
neuron differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 235 SHGTHLAGVVSGRDAGVAKGA - 18669648
HTP
0.02
 - Peptidase_S8
0.40
 2QTW 0.82%
S 688 CCRSRHLAQASQELQ       - 18669648
HTP
 - - -
0.27
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