Substrate: TLR3 (double-stranded RNA binding, transmembrane receptor activity)
Seq-ID: O15455 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2840114   P85A_HUMAN
MINT-2840132   SRC_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
double-stranded RNA binding,
transmembrane receptor activity		 integral to plasma membrane,
endoplasmic reticulum membrane,
endosome membrane		 defense response to bacterium,
positive regulation of toll-like receptor signaling pathway,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of interferon-beta production,
positive regulation of interleukin-6 production,
activation of NF-kappaB-inducing kinase activity,
defense response to virus,
I-kappaB phosphorylation,
positive regulation of interferon-beta biosynthetic process,
inflammatory response,
innate immune response,
positive regulation of inflammatory response,
positive regulation of interleukin-8 production,
positive regulation of NF-kappaB import into nucleus,
hyperosmotic response,
positive regulation of interleukin-12 production,
positive regulation of tumor necrosis factor production,
positive regulation of interferon-alpha biosynthetic process,
detection of virus,
negative regulation of osteoclast differentiation,
positive regulation of interferon-gamma biosynthetic process,
positive regulation of chemokine production
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 759 RQTEQFEYAAYIIHAYKDKDW - 12509442
LTP
1.00
 - TIR
0.04
 - low

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