INSTANCE INFORMATION

Substrate Protein Additional information about the substrate protein, which contains the phosphorylation site, pattern of expression, interaction partners and interaction network(s) (where available).

Accession Number Link to UniPROT/Ensembl entry.

Short Description Brief description of the substrate protein.

Interaction Network Links to STRING to allow retrieval of interacting genes/proteins and\or NetworKIN to allow the user to browse/search which kinase families are predicted to phosphorylate experimentally identified phosphorylation sites in vivo.

Position Position of the S/T/Y phosphorylation site within the UniPROT/TrEMBL sequence. (NB. position may differ from that given in literature due to differences in sequence entry).

Target Sequence Amino acid sequence of region flanking the modified residue (+/- 10 amino acids).

Kinase List of kinases which modify the given residue.

PubMed Link to PubMed entry(s) for publications reporting the evidence from which the data was collected. (NB. Site position quoted in literature may differ from that given in Phospho.ELM due to differences in sequence entry and annotation).

Source High Throughput Data (HTP); Low Throughput Data (LTP)

Binding motif The phosphorylation of the given residue creates a binding motif for a domain involved in signaling (e.g. SH2, 14-3-3, PTB).

PDB/MSD Link to a macromolecular structure database MSD-EBI entry containing a relevant structure covering the phosphorylated site.

SMART Note of any SMART domain predictions in which the phosphorylation instance resides.

ELM_ID Link to ELM server entry for the given phosphorylation and/or binding motif.

SUBSTRATE INFORMATION

Compartment Gene Ontology term for cell compartment in which the substrate is found.

Expression List of tissues in which substrate is known to be expressed.

Interaction Network Links to schematic representation of a signaling pathway in which the substrate is thought to be involved and/or links to Biocarta.

Interaction Partner Links to the Molecular INTeractions database for the interaction partners of the substrate.