a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Spry-2  SYK  c-met  ZAP70 

Substrate:	Spry-2 (Adaptor molecule)
Seq-ID:	O43597 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-6169734   GRB2_HUMAN MINT-6170603   SH3K1_HUMAN MINT-6539601   CBL_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process plasma membrane, cytosol, microtubule signal transduction, cell-cell signaling
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	55	QIRAIRNTNEYTEGPTVVPRP	-	15637081	LTP	1.00		CBL SH2	-	0.81	-	medium
Y	55	QIRAIRNTNEYTEGPTVVPRP	-	16000370	LTP	1.00		CBL SH2	-	0.81	-	medium
Y	55	QIRAIRNTNEYTEGPTVVPRP	-	12593795	LTP	1.00		CBL SH2	-	0.81	-	medium
Y	55	QIRAIRNTNEYTEGPTVVPRP	SRC	15564375	LTP	1.00		CBL SH2	-	0.81	-	medium
Y	55	QIRAIRNTNEYTEGPTVVPRP	-	12815057	LTP	1.00		CBL SH2	-	0.81	-	medium

Substrate:	SYK (Spleen tyrosine kinase )
Seq-ID:	P48025 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-56734   P85A_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein tyrosine kinase activity, non-membrane spanning protein tyrosine kinase activity, ATP binding B cell receptor complex, cytoplasm positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of interleukin-3 biosynthetic process, B cell receptor signaling pathway, serotonin secretion, positive regulation of alpha-beta T cell proliferation, positive regulation of calcium-mediated signaling, positive regulation of B cell differentiation, activation of JUN kinase activity, positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, beta selection, positive regulation of gamma-delta T cell differentiation, positive regulation of mast cell degranulation, leukotriene biosynthetic process, protein amino acid autophosphorylation, enzyme linked receptor protein signaling pathway, peptidyl-tyrosine phosphorylation, positive regulation of alpha-beta T cell differentiation, G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	317	RPESTVSFNPYEPTGGPWGPD	-	9857068	LTP	1.00		CBL SH2	-	0.69	-	-
Y	317	RPESTVSFNPYEPTGGPWGPD	Lyn	9820500	LTP	1.00		CBL SH2	-	0.69	-	-

Substrate:	c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID:	P08581 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-18299   RANB9_HUMAN MINT-58374   GAB1_MOUSE MINT-58404   GAB1_HUMAN MINT-6539587   CBL_HUMAN MINT-6787689   PTN1_HUMAN MINT-6798640   PTN11_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process hepatocyte growth factor receptor activity, ATP binding, protein binding integral to plasma membrane, basal plasma membrane protein amino acid phosphorylation, multicellular organismal development, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1003	TEMVSNESVDYRATFPEDQFP	-	11741535	LTP	1.00		CBL SH2	-	0.44	-	-
Y	1003	TEMVSNESVDYRATFPEDQFP	-	17192257	HTP	1.00		CBL SH2	-	0.44	-	-
Y	1003	TEMVSNESVDYRATFPEDQFP	-	18083107	HTP	1.00		CBL SH2	-	0.44	-	-

Substrate:	ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID:	P43403 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-59476   LCK_HUMAN MINT-60980   SHC1_HUMAN MINT-74806   ERBB3_HUMAN MINT-74807   EGFR_HUMAN MINT-3374106   HS90A_HUMAN MINT-3382488   LAT_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding cytosol, T cell receptor complex positive thymic T cell selection, immune response, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	292	RRIDTLNSDGYTPEPARITSP	Lck	8756661	LTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	ZAP70	8756661	LTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	Lck	7961936	LTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	ZAP70	7961936	LTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	15144186	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	15592455	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	16094384	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	15659558	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	17192257	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-