Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P43405 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56730   LCK_HUMAN
MINT-56732   P85A_HUMAN
MINT-56739   FGR_HUMAN
MINT-56749   P85B_HUMAN
MINT-74763   EGFR_HUMAN
MINT-74769   ERBB2_HUMAN
MINT-74775   ERBB3_HUMAN
MINT-74776   ERBB4_HUMAN
MINT-6538977   CBL_HUMAN
MINT-6621148   BLNK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
integrin binding		 cytoplasm,
T cell receptor complex		 protein complex assembly,
organ morphogenesis,
integrin-mediated signaling pathway,
neutrophil chemotaxis,
interspecies interaction between organisms,
cell proliferation,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 296 AGGIISRIKSYSFPKPGHRKS - 18083107
HTP
 - - -
0.41
 --
S 297 GGIISRIKSYSFPKPGHRKSS - 18088087
HTP
 - - -
0.44
 --
Y 323 RQESTVSFNPYEPELAPWAAD - 16497976
HTP
0.80
 CBLB SH2;
CBL PTB;
PIK3R1 SH2		 -
0.51
 --
Y 323 RQESTVSFNPYEPELAPWAAD - 18083107
HTP
0.80
 CBLB SH2;
CBL PTB;
PIK3R1 SH2		 -
0.51
 --
Y 348 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 348 REALPMDTEVYESPYADPEEI - 12522270
HTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 348 REALPMDTEVYESPYADPEEI - 18083107
HTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 352 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 352 PMDTEVYESPYADPEEIRPKE - 12522270
HTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 352 PMDTEVYESPYADPEEIRPKE - 18083107
HTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 525 LSKALRADENYYKAQTHGKWP SYK 8657103
LTP
1.00
 CBL PTB;
Lck SH2		 TyrKc
0.19
 1XBA 41.92%
Y 526 SKALRADENYYKAQTHGKWPV SYK 8657103
LTP
1.00
 CBL PTB;
Lck SH2		 TyrKc
0.17
 1XBA 30.57%
Y 526 SKALRADENYYKAQTHGKWPV - 18083107
HTP
1.00
 CBL PTB;
Lck SH2		 TyrKc
0.17
 1XBA 30.57%

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P48025 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-56734   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 B cell receptor complex,
cytoplasm		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of interleukin-3 biosynthetic process,
B cell receptor signaling pathway,
serotonin secretion,
positive regulation of alpha-beta T cell proliferation,
positive regulation of calcium-mediated signaling,
positive regulation of B cell differentiation,
activation of JUN kinase activity,
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process,
beta selection,
positive regulation of gamma-delta T cell differentiation,
positive regulation of mast cell degranulation,
leukotriene biosynthetic process,
protein amino acid autophosphorylation,
enzyme linked receptor protein signaling pathway,
peptidyl-tyrosine phosphorylation,
positive regulation of alpha-beta T cell differentiation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 130 EDLKENLIREYVKQTWNLQGQ Lyn 9820500
LTP
1.00
 - -
0.28
 --
Y 130 EDLKENLIREYVKQTWNLQGQ SYK 9820500
LTP
1.00
 - -
0.28
 --
Y 317 RPESTVSFNPYEPTGGPWGPD - 9857068
LTP
1.00
 CBL SH2 -
0.69
 --
Y 317 RPESTVSFNPYEPTGGPWGPD Lyn 9820500
LTP
1.00
 CBL SH2 -
0.69
 --
Y 342 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
1.00
 PLCG_group SH2;
VAV1 SH2		 -
0.58
 --
Y 342 REALPMDTEVYESPYADPEEI Lyn 9820500
LTP
1.00
 PLCG_group SH2;
VAV1 SH2		 -
0.58
 --
Y 346 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
 PLCG_group SH2 -
0.54
 --
Y 346 PMDTEVYESPYADPEEIRPKE Lyn 9820500
LTP
1.00
 PLCG_group SH2 -
0.54
 --
Y 358 DPEEIRPKEVYLDRSLLTLED SYK 8657103
LTP
0.16
 - -
0.44
 1XBA 68.12%
Y 519 LSKALRADENYYKAQTHGKWP SYK 8657103
LTP
1.00
 - TyrKc
0.19
 1XBA 41.92%
Y 520 SKALRADENYYKAQTHGKWPV SYK 8657103
LTP
1.00
 - TyrKc
0.17
 1XBA 30.57%

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