Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18299   RANB9_HUMAN
MINT-58374   GAB1_MOUSE
MINT-58404   GAB1_HUMAN
MINT-6539587   CBL_HUMAN
MINT-6787689   PTN1_HUMAN
MINT-6798640   PTN11_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
hepatocyte growth factor receptor activity,
ATP binding,
protein binding		 integral to plasma membrane,
basal plasma membrane		 protein amino acid phosphorylation,
multicellular organismal development,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 830 FFMLDGILSKYFDLIYVHNPV - 12746450
LTP
0.16
 - IPT
0.02
 --
T 977 ELVRYDARVHTPHLDRLVSAR - 17192257
HTP
0.18
 - -
0.27
 --
S 985 VHTPHLDRLVSARSVSPTTEM - 7925482
LTP
0.26
 - -
0.44
 --
S 985 VHTPHLDRLVSARSVSPTTEM PKC_delta 15075332
LTP
0.26
 - -
0.44
 --
S 985 VHTPHLDRLVSARSVSPTTEM PKC_epsilon 15075332
LTP
0.26
 - -
0.44
 --
S 985 VHTPHLDRLVSARSVSPTTEM PKC_group 8294430
LTP
0.26
 - -
0.44
 --
S 988 PHLDRLVSARSVSPTTEMVSN - 17192257
HTP
1.00
 - -
0.42
 --
S 988 PHLDRLVSARSVSPTTEMVSN - 18669648
HTP
1.00
 - -
0.42
 --
S 990 LDRLVSARSVSPTTEMVSNES - 17192257
HTP
1.00
 - -
0.41
 --
S 990 LDRLVSARSVSPTTEMVSNES - 18669648
HTP
1.00
 - -
0.41
 --
T 992 RLVSARSVSPTTEMVSNESVD - 18669648
HTP
1.00
 - -
0.40
 --
T 993 LVSARSVSPTTEMVSNESVDY - 18669648
HTP
0.24
 - -
0.40
 --
S 997 RSVSPTTEMVSNESVDYRATF - 18669648
HTP
1.00
 - -
0.45
 --
S 1000 SPTTEMVSNESVDYRATFPED - 18669648
HTP
1.00
 - -
0.45
 --
Y 1003 TEMVSNESVDYRATFPEDQFP - 11741535
LTP
1.00
 CBL SH2 -
0.44
 --
Y 1003 TEMVSNESVDYRATFPEDQFP - 17192257
HTP
1.00
 CBL SH2 -
0.44
 --
Y 1003 TEMVSNESVDYRATFPEDQFP - 18083107
HTP
1.00
 CBL SH2 -
0.44
 --
Y 1230 VADFGLARDMYDKEYYSVHNK Met 12475979
LTP
1.00
 - TyrKc
0.11
 3F66 34.06%
Y 1230 VADFGLARDMYDKEYYSVHNK - 18083107
HTP
1.00
 - TyrKc
0.11
 3F66 34.06%
Y 1234 GLARDMYDKEYYSVHNKTGAK Met 1247597
LTP
1.00
 - TyrKc
0.18
 3F66 31.88%
Y 1234 GLARDMYDKEYYSVHNKTGAK Met 8302603
LTP
1.00
 - TyrKc
0.18
 3F66 31.88%
Y 1234 GLARDMYDKEYYSVHNKTGAK Met 7961992
LTP
1.00
 - TyrKc
0.18
 3F66 31.88%
Y 1234 GLARDMYDKEYYSVHNKTGAK - 18083107
HTP
1.00
 - TyrKc
0.18
 3F66 31.88%
Y 1235 LARDMYDKEYYSVHNKTGAKL - 1247597
LTP
1.00
 - TyrKc
0.18
 3F66 10.48%
Y 1235 LARDMYDKEYYSVHNKTGAKL Met 8302603
LTP
1.00
 - TyrKc
0.18
 3F66 10.48%
Y 1235 LARDMYDKEYYSVHNKTGAKL - 18083107
HTP
1.00
 - TyrKc
0.18
 3F66 10.48%
Y 1313 LQPEYCPDPLYEVMLKCWHPK - 7708691
LTP
0.97
 PIK3R1 SH2;
STAT3 SH2		 TyrKc
0.10
 3F66 15.28%
Y 1313 LQPEYCPDPLYEVMLKCWHPK - 10069803
LTP
0.97
 PIK3R1 SH2;
STAT3 SH2		 TyrKc
0.10
 3F66 15.28%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 12475979
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9444958
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9252406
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 7513258
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7731718
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7687741
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9826708
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 12475979
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9444958
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9252406
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 8662889
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9826708
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1365 TYVNVKCVAPYPSLLSSEDNA - 12475979
LTP
1.00
 - -
0.21
 --

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P16056 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-58371   GAB1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
hepatocyte growth factor receptor activity,
ATP binding,
protein binding		 membrane fraction,
integral to membrane		 brain development,
muscle cell migration,
myotube differentiation,
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling,
placenta development,
adult behavior,
myoblast proliferation,
protein amino acid autophosphorylation,
activation of MAPK activity,
skeletal muscle tissue development,
liver development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1001 TEMVSNESVDYRATFPEDQFP - 7708691
LTP
1.00
 - -
0.44
 --
Y 1228 VADFGLARDMYDKEYYSVHNK Met 8302603
LTP
1.00
 - TyrKc
0.11
 3F66 34.06%
Y 1232 GLARDMYDKEYYSVHNKTGAK Met 8302603
LTP
1.00
 - TyrKc
0.17
 3F66 31.88%
Y 1233 LARDMYDKEYYSVHNKTGAKL Met 8302603
LTP
1.00
 - TyrKc
0.17
 3F66 10.48%
Y 1233 LARDMYDKEYYSVHNKTGAKL Met 1655790
LTP
1.00
 - TyrKc
0.17
 3F66 10.48%
Y 1311 LQPEYCPDALYEVMLKCWHPK - 10069803
LTP
0.97
 - TyrKc
0.07
 3F66 15.28%
Y 1347 SIFSTFIGEHYVHVNATYVNV - 7513258
LTP
1.00
 - -
0.03
 3F66 100.00%
Y 1347 SIFSTFIGEHYVHVNATYVNV - 10069803
LTP
1.00
 - -
0.03
 3F66 100.00%
Y 1347 SIFSTFIGEHYVHVNATYVNV - 8662733
LTP
1.00
 - -
0.03
 3F66 100.00%
Y 1347 SIFSTFIGEHYVHVNATYVNV - 7838524
LTP
1.00
 - -
0.03
 3F66 100.00%
Y 1347 SIFSTFIGEHYVHVNATYVNV - 7499247
LTP
1.00
 - -
0.03
 3F66 100.00%
Y 1347 SIFSTFIGEHYVHVNATYVNV - 8906793
LTP
1.00
 - -
0.03
 3F66 100.00%
Y 1354 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
 - -
0.05
 --
Y 1354 GEHYVHVNATYVNVKCVAPYP - 10069803
LTP
1.00
 - -
0.05
 --
Y 1354 GEHYVHVNATYVNVKCVAPYP - 8662733
LTP
1.00
 - -
0.05
 --
Y 1354 GEHYVHVNATYVNVKCVAPYP - 7838524
LTP
1.00
 - -
0.05
 --
Y 1354 GEHYVHVNATYVNVKCVAPYP - 7499247
LTP
1.00
 - -
0.05
 --
Y 1354 GEHYVHVNATYVNVKCVAPYP - 8906793
LTP
1.00
 - -
0.05
 --
Y 1363 TYVNVKCVAPYPSLLPSQDNI - 10069803
LTP
1.00
 - -
0.18
 --

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