Substrate: PDK1 (3-phosphoinositide dependent protein kinase-1; serine/threonine kinase)
Seq-ID: O15530 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13835   AKT1_HUMAN
MINT-14377   KS6B1_HUMAN
MINT-15996   1433F_HUMAN
MINT-16333   1433T_HUMAN
MINT-17466   FRAP_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
3-phosphoinositide-dependent protein kinase activity,
ATP binding,
protein binding		 plasma membrane,
cytosol		 intracellular signaling pathway,
actin cytoskeleton organization,
cellular response to insulin stimulus,
positive regulation of establishment of protein localization in plasma membrane,
negative regulation of protein kinase activity,
peptidyl-threonine phosphorylation,
activation of protein kinase B activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 9   MARTTSQLYDAVPIQSSVV SRC 11481331
LTP
0.68
 - -
0.44
 --
Y 9   MARTTSQLYDAVPIQSSVV - 15302935
HTP
0.68
 - -
0.44
 --
Y 9   MARTTSQLYDAVPIQSSVV RET 12738763
LTP
0.68
 - -
0.44
 --
Y 9   MARTTSQLYDAVPIQSSVV - 16314505
LTP
0.68
 - -
0.44
 --
S 25 QSSVVLCSCPSPSMVRTQTES PDK-1 10455013
LTP
0.91
 - -
0.53
 --
T 37 SMVRTQTESSTPPGIPGGSRQ - 18669648
HTP
0.47
 - -
0.90
 --
S 241 SPESKQARANSFVGTAQYVSP PDK-1 10455013
LTP
1.00
 YWHAH 14-3-3;
YWHAQ 14-3-3		 S_TKc
0.25
 1UU3 123.77%
S 241 SPESKQARANSFVGTAQYVSP - 15302935
HTP
1.00
 YWHAH 14-3-3;
YWHAQ 14-3-3		 S_TKc
0.25
 1UU3 123.77%
S 241 SPESKQARANSFVGTAQYVSP - 18669648
HTP
1.00
 YWHAH 14-3-3;
YWHAQ 14-3-3		 S_TKc
0.25
 1UU3 123.77%
T 245 KQARANSFVGTAQYVSPELLT - 17081983
HTP
1.00
 - S_TKc
0.21
 1UU3 23.97%
Y 373 PAMSEDDEDCYGNYDNLLSQF SRC 11481331
LTP
1.00
 - -
0.28
 --
Y 373 PAMSEDDEDCYGNYDNLLSQF - 15302935
HTP
1.00
 - -
0.28
 --
Y 376 SEDDEDCYGNYDNLLSQFGCM SRC 11481331
LTP
1.00
 - -
0.26
 --
Y 376 SEDDEDCYGNYDNLLSQFGCM - 15302935
HTP
1.00
 - -
0.26
 --
S 393 FGCMQVSSSSSSHSLSASDTG PDK-1 10455013
LTP
0.93
 - -
0.43
 --
S 396 MQVSSSSSSHSLSASDTGLPQ PDK-1 10455013
LTP
0.60
 - -
0.53
 --
S 410 SDTGLPQRSGSNIEQYIHDLD PDK-1 10455013
LTP
0.72
 - -
0.49
 1W1D 31.15%
T 513 ELRPEAKNFKTFFVHTPNRTY PDK-1 16780920
LTP
1.00
 - -
0.29
 1W1D 13.70%

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