Substrate: JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID: O60674 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   BRCA1_HUMAN
MINT-61281   G3BP1_HUMAN
MINT-74562   EGFR_HUMAN
MINT-74563   ERBB3_HUMAN
MINT-6764602   PTN1_HUMAN
MINT-7250518   NCK1_HUMAN
MINT-7251766   P85A_HUMAN
MINT-7252666   PLCG1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
Janus kinase activity,
histone kinase activity (H3-Y41 specific),
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
growth hormone receptor binding,
SH2 domain binding		 cytoskeleton,
endomembrane system		 activation of JAK2 kinase activity,
cytokine-mediated signaling pathway,
cellular component movement,
mesoderm development,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of tyrosine phosphorylation of Stat5 protein,
erythrocyte differentiation,
protein amino acid autophosphorylation,
JAK-STAT cascade involved in growth hormone signaling pathway,
response to antibiotic
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 570 FKGVRREVGDYGQLHETEVLL - 16464493
LTP
0.20
 - STYKc
0.19
 --
Y 813 RDLNSLFTPDYELLTENDMLP - 15767667
LTP
0.95
 SH2B1 SH2 -
0.28
 --
Y 1007 LTKVLPQDKEYYKVKEPGESP JAK2 9111318
LTP
1.00
 SOCS1 SH2;
SOCS3 SH2		 TyrKc
0.27
 3E62 61.14%
Y 1008 TKVLPQDKEYYKVKEPGESPI JAK2 11818507
LTP
1.00
 - TyrKc
0.25
 3E62 40.17%

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