Substrate: TNF alpha (Membrane bound ligand)
Seq-ID: P01375 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-49370   TNR1B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine activity,
identical protein binding,
promoter binding,
transcription repressor activity,
tumor necrosis factor receptor binding,
transcription activator activity		 external side of plasma membrane,
recycling endosome,
extracellular space,
phagocytic cup,
membrane raft,
integral to plasma membrane		 positive regulation of ERK1 and ERK2 cascade,
response to salt stress,
leukocyte tethering or rolling,
negative regulation of viral genome replication,
activation of caspase activity,
positive regulation of chemokine biosynthetic process,
positive regulation of smooth muscle cell proliferation,
positive regulation of gene-specific transcription,
negative regulation of cytokine secretion involved in immune response,
positive regulation of membrane protein ectodomain proteolysis,
positive regulation of NF-kappaB import into nucleus,
activation of MAPK activity,
positive regulation of NF-kappaB transcription factor activity,
sequestering of triglyceride,
positive regulation of calcidiol 1-monooxygenase activity,
positive regulation of heterotypic cell-cell adhesion,
regulation of insulin secretion,
negative regulation of lipid catabolic process,
receptor biosynthetic process,
response to glucocorticoid stimulus,
negative regulation of interleukin-6 production,
positive regulation of chemokine production,
protein import into nucleus, translocation,
transformed cell apoptosis,
negative regulation of gene-specific transcription,
chronic inflammatory response to antigenic stimulus,
response to virus,
positive regulation of protein amino acid phosphorylation,
tumor necrosis factor-mediated signaling pathway,
necrotic cell death,
positive regulation of cytokine secretion,
induction of necroptosis by extracellular signals,
negative regulation of fat cell differentiation,
positive regulation of fever,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
positive regulation of nitric oxide biosynthetic process,
anti-apoptosis,
positive regulation of vitamin D biosynthetic process,
negative regulation of lipid storage,
negative regulation of branching involved in lung morphogenesis
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 2          MSTESMIRDVEL CK2_group 8597870
LTP
0.36
 - -
0.27
 - medium

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