Substrate: Raf1 (RAF proto-oncogene serine/threonine-protein kinase)
Seq-ID: P04049 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19324   KPYM_HUMAN
MINT-24923   RAP1A_HUMAN
MINT-45800   1433Z_HUMAN
MINT-51053   K1C19_HUMAN
MINT-51055   K1C18_HUMAN
MINT-51056   K2C8_HUMAN
MINT-56513   CNKR1_HUMAN
MINT-3389399   PAK1_HUMAN
MINT-3389607   PEBP1_HUMAN
MINT-3975386   1433S_HUMAN
MINT-6946517   RASH_HUMAN
MINT-7014370   MP2K1_HUMAN
MINT-7014449   AKT1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
receptor signaling protein activity,
ATP binding,
protein binding		 plasma membrane,
cytosol,
mitochondrial outer membrane		 protein amino acid phosphorylation,
negative regulation of cell proliferation,
apoptosis,
Ras protein signal transduction,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 29 DAVFDGSSCISPTIVQQFGYQ - 15664191
LTP
0.96
 PIN1 WW -
0.17
 - medium
S 43 VQQFGYQRRASDDGKLTDPSK PKA_group 11971957
LTP
1.00
 MOD_PKA_1
 - -
0.48
 - medium
S 233 RMPVSSQHRYSTPHAFTFNTS - 12801936
LTP
0.22
 - -
0.51
 - medium
S 252 TSSPSSEGSLSQRQRSTSTPN - 17525332
HTP
0.83
 - -
0.82
 - medium
S 257 SEGSLSQRQRSTSTPNVHMVS - 18220336
HTP
1.00
 - -
0.76
 - medium
T 258 EGSLSQRQRSTSTPNVHMVST - 18220336
HTP
1.00
 - -
0.74
 - medium
T 258 EGSLSQRQRSTSTPNVHMVST - 18669648
HTP
1.00
 - -
0.74
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT PKA_group 11971957
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT PKB_group 10576742
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT - 12801936
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT - 18220336
HTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT - 18669648
HTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
T 260 SLSQRQRSTSTPNVHMVSTTL - 18220336
HTP
1.00
 - -
0.73
 - medium
T 269 STPNVHMVSTTLPVDSRMIED KSR1 11134016
LTP
0.32
 - -
0.59
 - medium
T 269 STPNVHMVSTTLPVDSRMIED KSR1 7477354
LTP
0.32
 - -
0.59
 - medium
S 289 DAIRSHSESASPSALSSSPNN - 15664191
LTP
0.65
 PIN1 WW -
0.74
 - medium
S 294 HSESASPSALSSSPNNLSPTG - 17081983
HTP
0.08
 - -
0.76
 - medium
S 296 ESASPSALSSSPNNLSPTGWS - 15664191
LTP
0.52
 PIN1 WW -
0.75
 - medium
S 301 SALSSSPNNLSPTGWSQPKTP - 15664191
LTP
0.19
 PIN1 WW -
0.77
 - medium
S 301 SALSSSPNNLSPTGWSQPKTP - 17081983
HTP
0.19
 PIN1 WW -
0.77
 - medium
S 338 NKIRPRGQRDSSYYWEIEASE PAK_group 11376654
LTP
0.96
 - -
0.43
 - medium
S 338 NKIRPRGQRDSSYYWEIEASE PAK1 11733498
LTP
0.96
 - -
0.43
 - medium
S 338 NKIRPRGQRDSSYYWEIEASE - 12719581
LTP
0.96
 - -
0.43
 - medium
S 338 NKIRPRGQRDSSYYWEIEASE PAK1 10801448
LTP
0.96
 - -
0.43
 - medium
S 338 NKIRPRGQRDSSYYWEIEASE PAK_group 9823899
LTP
0.96
 - -
0.43
 - medium
S 338 NKIRPRGQRDSSYYWEIEASE PAK3 9823899
LTP
0.96
 - -
0.43
 - medium
S 339 KIRPRGQRDSSYYWEIEASEV PAK1 15849194
LTP
0.93
 - -
0.41
 - medium
Y 340 IRPRGQRDSSYYWEIEASEVM - 11134016
LTP
0.91
 - -
0.40
 - medium
Y 341 RPRGQRDSSYYWEIEASEVML SRC 10205168
LTP
0.91
 - -
0.37
 - medium
S 471 AKNIIHRDMKSNNIFLHEGLT - 16093354
LTP
1.00
 - STYKc
0.15
 - medium
T 491 TVKIGDFGLATVKSRWSGSQQ - 15258589
LTP
1.00
 - STYKc
0.19
 - medium
T 491 TVKIGDFGLATVKSRWSGSQQ - 11447113
LTP
1.00
 - STYKc
0.19
 - medium
S 494 IGDFGLATVKSRWSGSQQVEQ - 15258589
LTP
0.80
 - STYKc
0.28
 - medium
S 499 LATVKSRWSGSQQVEQPTGSV PKC_group 8321321
LTP
1.00
 - STYKc
0.33
 - medium
S 621 HSLPKINRSASEPSLHRAAHT PKA_group 11971957
LTP
0.99
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.49
 - medium
S 621 HSLPKINRSASEPSLHRAAHT - 9091312
LTP
0.99
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.49
 - medium
S 642 EDINACTLTTSPRLPVF     - 18669648
HTP
0.53
 PIN1 WW -
0.27
 - medium

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