Substrate: ErbB2 (Receptor tyrosine kinase)
Seq-ID: P04626 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61505   P85B_HUMAN
MINT-74429   ABL1_HUMAN
MINT-74444   ABL2_HUMAN
MINT-74462   ANS1A_HUMAN
MINT-74470   APBB1_HUMAN
MINT-74486   BLNK_HUMAN
MINT-74488   BMX_HUMAN
MINT-74498   CRK_HUMAN
MINT-74502   CRKL_HUMAN
MINT-74508   DAB1_HUMAN
MINT-74512   DOK1_HUMAN
MINT-74521   SPT6H_HUMAN
MINT-74533   FER_HUMAN
MINT-74538   FGR_HUMAN
MINT-74540   GRAP2_HUMAN
MINT-74542   GRB2_HUMAN
MINT-74544   GRB7_HUMAN
MINT-74553   IRS1_HUMAN
MINT-74556   IRS4_HUMAN
MINT-74558   ITK_HUMAN
MINT-74561   JAK1_HUMAN
MINT-74567   SH2B3_HUMAN
MINT-74575   JIP1_HUMAN
MINT-74582   MATK_HUMAN
MINT-74590   NCK2_HUMAN
MINT-74610   P85A_HUMAN
MINT-74664   P55G_HUMAN
MINT-74680   PLCG1_HUMAN
MINT-74686   PLCG2_HUMAN
MINT-74691   PTN11_HUMAN
MINT-74712   RASA1_HUMAN
MINT-74713   RIN1_HUMAN
MINT-74722   SH22A_HUMAN
MINT-74723   SH23A_HUMAN
MINT-74724   3BP2_HUMAN
MINT-74737   SHC1_HUMAN
MINT-74747   SLAP1_HUMAN
MINT-74755   STAT1_HUMAN
MINT-74756   STAT3_HUMAN
MINT-74769   KSYK_HUMAN
MINT-74777   TEC_HUMAN
MINT-74781   TENC1_HUMAN
MINT-74786   TENS3_HUMAN
MINT-74793   TLN1_HUMAN
MINT-74794   TXK_HUMAN
MINT-74802   VAV2_HUMAN
MINT-1788719   EGFR_HUMAN
MINT-1901925   LAP2_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
ErbB-3 class receptor binding,
protein heterodimerization activity,
DNA binding,
protein C-terminus binding,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
ATP binding,
protein phosphatase binding		 receptor complex,
integral to membrane,
nucleus,
perinuclear region of cytoplasm		 regulation of angiogenesis,
transcription,
regulation of transcription,
phosphoinositide 3-kinase cascade,
phosphoinositide-mediated signaling,
heart development,
positive regulation of cell adhesion,
protein amino acid autophosphorylation,
positive regulation of epithelial cell proliferation,
wound healing,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 686 KRRQQKIRKYTMRRLLQETEL - 8702975
LTP
1.00
 - -
0.29
 - low
T 686 KRRQQKIRKYTMRRLLQETEL - 9855018
LTP
1.00
 - -
0.29
 - low
Y 735 VLGSGAFGTVYKGIWIPDGEN - 18083107
HTP
1.00
 - TyrKc
0.09
 - low
Y 877 ARLLDIDETEYHADGGKVPIK - 15695410
LTP
1.00
 - TyrKc
0.16
 - low
S 1054 HHRHRSSSTRSGGGDLTLGLE - 18669648
HTP
0.30
 - -
0.77
 - low
Y 1112 PTHDPSPLQRYSEDPTVPLPS - 10910043
LTP
1.00
 - -
0.92
 - low
S 1134 TDGYVAPLTCSPQPEYVNQPD - 18669648
HTP
0.12
 - -
0.74
 - low
Y 1139 APLTCSPQPEYVNQPDVRPQP ErbB2 11500516
LTP
1.00
 GRB2 SH2;
GRB7 SH2;
Src SH2;
STAT3 SH2		 -
0.85
 - low
S 1151 NQPDVRPQPPSPREGPLPAAR - 18669648
HTP
0.09
 - -
0.95
 - low
T 1172 PAGATLERPKTLSPGKNGVVK CaM-KII_alpha 8700533
LTP
0.30
 - -
0.76
 - low
Y 1196 AFGGAVENPEYLTPQGGAAPQ ErbB2 11500516
LTP
1.00
 - YLP
0.78
 - low
Y 1221 PAFSPAFDNLYYWDQDPPERG ErbB2 11500516
LTP
0.19
 GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.67
 - low
Y 1222 AFSPAFDNLYYWDQDPPERGA ErbB2 11500516
LTP
1.00
 SHC_group SH2;
STAT3 SH2		 -
0.68
 - low
Y 1248 KGTPTAENPEYLGLDVPV    ErbB2 11500516
LTP
1.00
 MATK SH2 -
0.69
 - low
Y 1248 KGTPTAENPEYLGLDVPV    - 17081983
HTP
1.00
 MATK SH2 -
0.69
 - low

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