Substrate: Amyloid beta A4 protein (Cell surface receptor)
Seq-ID: P05067 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-14547   JIP1_HUMAN
MINT-49648   APBB1_RAT
MINT-49659   GRB2_HUMAN
MINT-49660   SHC1_HUMAN
MINT-49984   ABL1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
serine-type endopeptidase inhibitor activity,
DNA binding,
acetylcholine receptor binding,
identical protein binding,
metal ion binding,
heparin binding		 extracellular region,
dendritic shaft,
integral to plasma membrane,
coated pit,
cell surface,
Golgi apparatus,
platelet alpha granule lumen,
axon,
dendritic spine		 dendrite development,
G2 phase of mitotic cell cycle,
positive regulation of mitotic cell cycle,
regulation of multicellular organism growth,
regulation of epidermal growth factor receptor activity,
ionotropic glutamate receptor signaling pathway,
mRNA polyadenylation,
collateral sprouting in the absence of injury,
adult locomotory behavior,
extracellular matrix organization,
Notch signaling pathway,
regulation of translation,
visual learning,
neuron apoptosis,
axon midline choice point recognition,
cell adhesion,
neuron remodeling,
mating behavior,
endocytosis,
axon cargo transport,
cellular copper ion homeostasis,
protein amino acid phosphorylation,
regulation of synapse structure and activity
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 743 HGVVEVDAAVTPEERHLSKMQ GSK-3_beta 8764598
LTP
1.00
 - APP_amyloid
0.47
 --
Y 757 RHLSKMQQNGYENPTYKFFEQ - 11279131
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
SHC1 SH2		 APP_amyloid
0.38
 --
Y 757 RHLSKMQQNGYENPTYKFFEQ - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
SHC1 SH2		 APP_amyloid
0.38
 --
Y 762 MQQNGYENPTYKFFEQMQN   - 18083107
HTP
1.00
 APBA1 PTB;
APBA2 PTB;
APBA3 PTB;
APBB1 PTB;
DAB1 PTB;
MAPK8IP2 PTB		 APP_amyloid
0.38
 --

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