Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Integrin beta 3 (Platelet membrane glycoprotein IIIa)

Seq-ID:

P05106 [Homo sapiens]

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Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

MINT Interaction(s):

[show]

MINT-25081   ITAV_HUMAN
MINT-45900   EPS8_HUMAN
MINT-45905   RBGP1_HUMAN
MINT-45913   GULP1_HUMAN
MINT-45916   RGS12_HUMAN
MINT-45923   DAB1_MOUSE
MINT-45928   DAB2_MOUSE
MINT-45939   IRS1_RAT
MINT-45952   TLN1_MOUSE
MINT-45957   JIP1_HUMAN
MINT-45960   LIN10_CAEEL
MINT-61480   TENC1_HUMAN
MINT-61568   DOK1_MOUSE
MINT-61569   NUMB_MOUSE
MINT-1795026   TLN1_HUMAN
MINT-6794817   PTN1_HUMAN
MINT-7384376   SRC_MOUSE
MINT-7384444   LYN_HUMAN
MINT-7384460   YES_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, vascular endothelial growth factor receptor 2 binding, identical protein binding, platelet-derived growth factor receptor binding, cell adhesion molecule binding	integrin complex, alphav-beta3 integrin-vitronectin complex, platelet alpha granule membrane	positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of endothelial cell proliferation, regulation of bone resorption, blood coagulation, negative regulation of lipid transport, tube development, activation of protein kinase activity, integrin-mediated signaling pathway, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, cell-matrix adhesion, interspecies interaction between organisms, smooth muscle cell migration, negative regulation of lipoprotein metabolic process, angiogenesis involved in wound healing, positive regulation of endothelial cell migration, negative regulation of low-density lipoprotein receptor biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	773	AKWDTANNPLYKEATSTFTNI	-	8631894	LTP	1.00		GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
Y	773	AKWDTANNPLYKEATSTFTNI	SRC	15699036	LTP	1.00		GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
Y	773	AKWDTANNPLYKEATSTFTNI	-	18088087	HTP	1.00		GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
Y	773	AKWDTANNPLYKEATSTFTNI	SRC	18398066	LTP	1.00		GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
T	777	TANNPLYKEATSTFTNITYRG	PDK-1	10896934	LTP	1.00		-	Integrin_b_cyt	0.27	-	-
T	779	NNPLYKEATSTFTNITYRGT	PDK-1	10896934	LTP	1.00		-	Integrin_b_cyt	0.27	-	-
Y	785	EATSTFTNITYRGT	SYK	8631894	LTP	0.98		PTPN11 SH2; SHC1 PTB; SYK SH2	Integrin_b_cyt	0.26	-	-
Y	785	EATSTFTNITYRGT	SRC	8631894	LTP	0.98		PTPN11 SH2; SHC1 PTB; SYK SH2	Integrin_b_cyt	0.26	-	-
Y	785	EATSTFTNITYRGT	-	18088087	HTP	0.98		PTPN11 SH2; SHC1 PTB; SYK SH2	Integrin_b_cyt	0.26	-	-