Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin-like growth factor receptor binding,
insulin binding,
PTB domain binding,
GTP binding,
metal ion binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity		 microsome,
caveola,
insulin receptor complex,
endosome membrane		 positive regulation of glycolysis,
positive regulation of MAPKKK cascade,
positive regulation of developmental growth,
regulation of embryonic development,
heart morphogenesis,
positive regulation of cell migration,
carbohydrate metabolic process,
protein heterotetramerization,
positive regulation of protein kinase B signaling cascade,
protein amino acid autophosphorylation,
activation of MAPK activity,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
positive regulation of glucose import,
positive regulation of respiratory burst,
activation of protein kinase B activity,
G-protein coupled receptor protein signaling pathway,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
regulation of gene-specific transcription
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 400 EISGYLKIRRSYALVSLSFFR - 18669648
HTP
1.00
 - Recep_L_domain
0.03
 2HR7 0.00%
Y 401 ISGYLKIRRSYALVSLSFFRK - 18669648
HTP
0.97
 - Recep_L_domain
0.03
 2HR7 58.08%
S 407 IRRSYALVSLSFFRKLRLIRG - 18669648
HTP
1.00
 - Recep_L_domain
0.04
 2HR7 18.85%
Y 992 RQPDGPLGPLYASSNPEYLSA INSR 1658004
LTP
1.00
 GRB2 SH2 -
0.33
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 1011 SASDVFPCSVYVPDEWEVSRE INSR 12707268
LTP
0.06
 GRB2 SH2 -
0.11
 1IR3 77.98%
S 1062 TRVAVKTVNESASLRERIEFL PKC_alpha 7926007
LTP
1.00
 - TyrKc
0.28
 1IR3 88.52%
S 1064 VAVKTVNESASLRERIEFLNE PKC_alpha 7926007
LTP
0.99
 - TyrKc
0.26
 1IR3 45.90%
Y 1185 IGDFGMTRDIYETDYYRKGGK INSR 7806540
LTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 100.87%
Y 1185 IGDFGMTRDIYETDYYRKGGK - 18083107
HTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 100.87%
Y 1189 GMTRDIYETDYYRKGGKGLLP INSR 7806540
LTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 67.69%
Y 1189 GMTRDIYETDYYRKGGKGLLP - 9506989
LTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 67.69%
Y 1189 GMTRDIYETDYYRKGGKGLLP - 18083107
HTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 67.69%
Y 1190 MTRDIYETDYYRKGGKGLLPV INSR 7806540
LTP
1.00
 GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2		 TyrKc
0.17
 1IR3 44.54%
Y 1190 MTRDIYETDYYRKGGKGLLPV - 9506989
LTP
1.00
 GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2		 TyrKc
0.17
 1IR3 44.54%
Y 1190 MTRDIYETDYYRKGGKGLLPV - 18083107
HTP
1.00
 GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2		 TyrKc
0.17
 1IR3 44.54%
S 1332 EDMENVPLDRSSHCQREEAGG - 2136851
LTP
0.95
 - -
0.70
 --
S 1333 DMENVPLDRSSHCQREEAGGR - 2136851
LTP
1.00
 - -
0.72
 --
S 1348 EEAGGRDGGSSLGFKRSYEEH - 10940390
LTP
0.94
 - -
0.59
 --
S 1354 DGGSSLGFKRSYEEHIPYTHM - 1321605
LTP
0.83
 - -
0.50
 --
Y 1355 GGSSLGFKRSYEEHIPYTHMN INSR 1321605
LTP
0.85
 GRB10 SH2;
PIK3R1 SH2		 -
0.50
 --
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
 Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2		 -
0.54
 --
T 1375 NGGKKNGRILTLPRSNPS    - 1956339
LTP
0.21
 - -
0.74
 --
T 1375 NGGKKNGRILTLPRSNPS    - 8454604
LTP
0.21
 - -
0.74
 --
T 1375 NGGKKNGRILTLPRSNPS    PKC_group 2110001
LTP
0.21
 - -
0.74
 --
T 1375 NGGKKNGRILTLPRSNPS    PKC_alpha 2110001
LTP
0.21
 - -
0.74
 --

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