Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15644   GRB10_HUMAN
MINT-18053   IRS2_HUMAN
MINT-1774754   ARHGC_MOUSE
MINT-1774976   ARHGC_HUMAN
MINT-6800783   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
identical protein binding,
insulin-like growth factor receptor activity,
insulin binding,
metal ion binding,
insulin receptor binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding		 microsome,
integral to plasma membrane		 positive regulation of DNA replication,
positive regulation of cell proliferation,
positive regulation of cell migration,
anti-apoptosis,
phosphoinositide 3-kinase cascade,
phosphoinositide-mediated signaling,
immune response,
protein amino acid autophosphorylation,
insulin receptor signaling pathway,
protein tetramerization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8550552
LTP
1.00
 CRK SH2;
Csk SH2		 -
0.16
 --
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8940173
LTP
1.00
 CRK SH2;
Csk SH2		 -
0.16
 --
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8550552
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7537849
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7559478
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK SRC 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK - 18083107
HTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP SRC 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP - 18083107
HTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV SRC 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV - 18083107
HTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1280 MEPGFREVSFYYSEENKLPEP IGF1R 8940173
LTP
0.28
 - -
0.44
 1P4O 14.41%
Y 1280 MEPGFREVSFYYSEENKLPEP - 8972223
LTP
0.28
 - -
0.44
 1P4O 14.41%
Y 1281 EPGFREVSFYYSEENKLPEPE IGF1R 8550552
LTP
1.00
 - -
0.43
 1P4O 29.26%
Y 1281 EPGFREVSFYYSEENKLPEPE - 8972223
LTP
1.00
 - -
0.43
 1P4O 29.26%
S 1339 PGPGVLVLRASFDERQPYAHM - 18669648
HTP
0.92
 - -
0.52
 --
Y 1346 LRASFDERQPYAHMNGGRKNE IGF1R 8550552
LTP
1.00
 Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.63
 --

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