Substrate: Retinoic acid receptor alpha (Nuclear hormone receptor family)
Seq-ID: P10276 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-24895   RXRA_HUMAN
MINT-25022   RXRA_MOUSE
MINT-2834436   NCOA3_HUMAN
MINT-2862542   UBE3A_HUMAN
MINT-5209864   NCOA1_HUMAN
MINT-5209905   MED1_HUMAN
MINT-7972514   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
retinoic acid binding,
retinoic acid receptor activity,
chromatin DNA binding,
protein domain specific binding,
transcription corepressor activity,
enzyme binding,
retinoic acid-responsive element binding,
transcription coactivator activity,
zinc ion binding,
receptor binding,
sequence-specific DNA binding transcription factor activity,
steroid hormone receptor activity		 cytoplasm,
cell surface,
nucleus		 negative regulation of granulocyte differentiation,
negative regulation of tumor necrosis factor production,
positive regulation of cell cycle,
response to estradiol stimulus,
positive regulation of gene-specific transcription,
positive regulation of interleukin-5 production,
positive regulation of binding,
cellular response to estrogen stimulus,
estrogen receptor signaling pathway,
cellular response to retinoic acid,
negative regulation of interferon-gamma production,
positive regulation of transcription from RNA polymerase II promoter,
apoptotic cell clearance,
positive regulation of interleukin-13 production,
negative regulation of gene-specific transcription,
positive regulation of interleukin-4 production,
positive regulation of cell proliferation,
protein amino acid phosphorylation,
transcription,
positive regulation of T-helper 2 cell differentiation
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 77 SSEEIVPSPPSPPPLPRIYKP CDK7 9230306
LTP
0.97
 - -
0.48
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