Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Bcl-2 (Apoptosis regulator Bcl-2)

Seq-ID:

P10415 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

MINT Interaction(s):

[show]

MINT-13660   B2L11_MOUSE
MINT-51440   MK01_HUMAN
MINT-51443   PP2AA_HUMAN
MINT-56637   FKBP8_HUMAN
MINT-56639   MK08_HUMAN
MINT-58237   CANB1_HUMAN
MINT-6629252   B2L11_HUMAN
MINT-7235965   ASPP2_HUMAN
MINT-7712827   BECN1_HUMAN
MINT-7717145   NAF1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein homodimerization activity, transcription activator activity, protease binding, BH3 domain binding, sequence-specific DNA binding	nuclear membrane, integral to membrane, mitochondrial outer membrane, endoplasmic reticulum membrane	negative regulation of cellular pH reduction, positive regulation of cell growth, regulation of protein homodimerization activity, response to toxin, anti-apoptosis, humoral immune response, defense response to virus, release of cytochrome c from mitochondria, response to drug, regulation of mitochondrial membrane potential, regulation of mitochondrial membrane permeability, regulation of protein heterodimerization activity, response to cytokine stimulus, apoptosis in response to endoplasmic reticulum stress, neuron apoptosis, female pregnancy, negative regulation of neuron apoptosis, response to iron ion, activation of pro-apoptotic gene products, negative regulation of mitochondrial depolarization, response to nicotine, protein polyubiquitination, B cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	56	PGIFSSQPGHTPHPAASRDPV	-	12039864	LTP	0.17		-	-	0.77	-	-
T	69	PAASRDPVARTSPLQTPAAPG	MAPK_group	10567572	LTP	0.09	MOD_ProDKin_1	-	-	0.75	-	-
S	70	AASRDPVARTSPLQTPAAPGA	MAPK_group	10567572	LTP	1.00	MOD_ProDKin_1	PIN1 WW	-	0.75	-	-
S	70	AASRDPVARTSPLQTPAAPGA	MAPK8	10567572	LTP	1.00	MOD_ProDKin_1	PIN1 WW	-	0.75	-	-
T	74	DPVARTSPLQTPAAPGAAAGP	-	12039864	LTP	0.75		-	-	0.68	-	-
S	87	APGAAAGPALSPVPPVVHLTL	MAPK_group	10567572	LTP	0.32	MOD_ProDKin_1	PIN1 WW	-	0.43	-	-
S	87	APGAAAGPALSPVPPVVHLTL	MAPK8	10567572	LTP	0.32	MOD_ProDKin_1	PIN1 WW	-	0.43	-	-