Substrate: DNA topoisomerase II, alpha (DNA topoisomerase II alpha)
Seq-ID: P11388 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-15316   PIN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
DNA topoisomerase (ATP-hydrolyzing) activity,
protein heterodimerization activity,
protein C-terminus binding,
protein homodimerization activity,
DNA-dependent ATPase activity,
chromatin binding,
histone deacetylase binding,
ATP binding,
ubiquitin binding,
drug binding		 DNA topoisomerase complex (ATP-hydrolyzing),
cytoplasm,
chromosome,
nucleoplasm		 DNA repair,
chromosome segregation,
phosphoinositide-mediated signaling,
positive regulation of apoptosis,
DNA ligation,
apoptotic chromosome condensation,
DNA topological change,
DNA replication,
positive regulation of retroviral genome replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 4        MEVSPLQPVNENMQ - 17081983
HTP
0.48
 - -
0.48
 --
S 29 KKNEDAKKRLSVERIYQKKTQ PKC_group 7499337
LTP
1.00
 - -
0.40
 1ZXM 59.02%
S 29 KKNEDAKKRLSVERIYQKKTQ - 17081983
HTP
1.00
 - -
0.40
 1ZXM 59.02%
S 1106 KVPDEEENEESDNEKETEKSD - 16565220
HTP
0.28
 - TOP4c
0.88
 --
S 1106 KVPDEEENEESDNEKETEKSD - 17081983
HTP
0.28
 - TOP4c
0.88
 --
S 1106 KVPDEEENEESDNEKETEKSD - 17287340
HTP
0.28
 - TOP4c
0.88
 --
S 1106 KVPDEEENEESDNEKETEKSD - 18669648
HTP
0.28
 - TOP4c
0.88
 --
S 1213 KKTQMAEVLPSPRGQRVIPRI CDK1 7635160
LTP
0.91
 MOD_ProDKin_1
 - -
0.70
 --
S 1213 KKTQMAEVLPSPRGQRVIPRI MAPK1 7635160
LTP
0.91
 MOD_ProDKin_1
 - -
0.70
 --
S 1213 KKTQMAEVLPSPRGQRVIPRI MAPK3 7635160
LTP
0.91
 MOD_ProDKin_1
 - -
0.70
 --
S 1213 KKTQMAEVLPSPRGQRVIPRI - 16565220
HTP
0.91
 MOD_ProDKin_1
 - -
0.70
 --
S 1213 KKTQMAEVLPSPRGQRVIPRI - 17081983
HTP
0.91
 MOD_ProDKin_1
 - -
0.70
 --
S 1213 KKTQMAEVLPSPRGQRVIPRI - 16964243
HTP
0.91
 MOD_ProDKin_1
 - -
0.70
 --
S 1213 KKTQMAEVLPSPRGQRVIPRI - 18220336
HTP
0.91
 MOD_ProDKin_1
 - -
0.70
 --
S 1213 KKTQMAEVLPSPRGQRVIPRI - 18669648
HTP
0.91
 MOD_ProDKin_1
 - -
0.70
 --
T 1244 KNKKKIKNENTEGSPQEDGVE - 18669648
HTP
0.10
 - -
0.83
 --
S 1247 KKIKNENTEGSPQEDGVELEG CDK1 7635160
LTP
0.20
 MOD_ProDKin_1
 - -
0.82
 --
S 1247 KKIKNENTEGSPQEDGVELEG MAPK1 7635160
LTP
0.20
 MOD_ProDKin_1
 - -
0.82
 --
S 1247 KKIKNENTEGSPQEDGVELEG MAPK3 7635160
LTP
0.20
 MOD_ProDKin_1
 - -
0.82
 --
S 1247 KKIKNENTEGSPQEDGVELEG - 16565220
HTP
0.20
 MOD_ProDKin_1
 - -
0.82
 --
S 1247 KKIKNENTEGSPQEDGVELEG - 17081983
HTP
0.20
 MOD_ProDKin_1
 - -
0.82
 --
S 1247 KKIKNENTEGSPQEDGVELEG - 17287340
HTP
0.20
 MOD_ProDKin_1
 - -
0.82
 --
S 1247 KKIKNENTEGSPQEDGVELEG - 18669648
HTP
0.20
 MOD_ProDKin_1
 - -
0.82
 --
S 1295 IKKGKKRNPWSDSESDRSSDE - 16565220
HTP
0.83
 - -
0.83
 --
S 1297 KGKKRNPWSDSESDRSSDESN - 16565220
HTP
0.46
 - -
0.83
 --
T 1327 PRRAATKTKFTMDLDSDEDFS - 18669648
HTP
0.67
 - -
0.70
 --
S 1332 TKTKFTMDLDSDEDFSDFDEK - 17081983
HTP
0.14
 - -
0.64
 --
S 1332 TKTKFTMDLDSDEDFSDFDEK - 18669648
HTP
0.14
 - -
0.64
 --
S 1337 TMDLDSDEDFSDFDEKTDDED - 17081983
HTP
0.47
 - -
0.68
 --
S 1337 TMDLDSDEDFSDFDEKTDDED - 18669648
HTP
0.47
 - -
0.68
 --
T 1343 DEDFSDFDEKTDDEDFVPSDA CK2_group 9804834
LTP
0.12
 MOD_CK2_1
 - -
0.73
 --
T 1343 DEDFSDFDEKTDDEDFVPSDA PKC_beta 7499337
LTP
0.12
 MOD_CK2_1
 - -
0.73
 --
T 1343 DEDFSDFDEKTDDEDFVPSDA - 17081983
HTP
0.12
 MOD_CK2_1
 - -
0.73
 --
T 1343 DEDFSDFDEKTDDEDFVPSDA - 18669648
HTP
0.12
 MOD_CK2_1
 - -
0.73
 --
S 1351 EKTDDEDFVPSDASPPKTKTS - 16565220
HTP
0.16
 - -
0.86
 --
S 1351 EKTDDEDFVPSDASPPKTKTS - 17081983
HTP
0.16
 - -
0.86
 --
S 1351 EKTDDEDFVPSDASPPKTKTS - 18669648
HTP
0.16
 - -
0.86
 --
S 1354 DDEDFVPSDASPPKTKTSPKL CDK1 7635160
LTP
0.04
 MOD_CDK_SPxK_1
 - -
0.87
 --
S 1354 DDEDFVPSDASPPKTKTSPKL MAPK1 7635160
LTP
0.04
 MOD_CDK_SPxK_1
 - -
0.87
 --
S 1354 DDEDFVPSDASPPKTKTSPKL MAPK3 7635160
LTP
0.04
 MOD_CDK_SPxK_1
 - -
0.87
 --
S 1354 DDEDFVPSDASPPKTKTSPKL - 16565220
HTP
0.04
 MOD_CDK_SPxK_1
 - -
0.87
 --
S 1354 DDEDFVPSDASPPKTKTSPKL - 17081983
HTP
0.04
 MOD_CDK_SPxK_1
 - -
0.87
 --
S 1354 DDEDFVPSDASPPKTKTSPKL - 18669648
HTP
0.04
 MOD_CDK_SPxK_1
 - -
0.87
 --
T 1358 FVPSDASPPKTKTSPKLSNKE - 18669648
HTP
0.04
 - -
0.87
 --
S 1361 SDASPPKTKTSPKLSNKELKP CDK1 7635160
LTP
0.24
 MOD_ProDKin_1
 - -
0.89
 --
S 1361 SDASPPKTKTSPKLSNKELKP MAPK1 7635160
LTP
0.24
 MOD_ProDKin_1
 - -
0.89
 --
S 1361 SDASPPKTKTSPKLSNKELKP MAPK3 7635160
LTP
0.24
 MOD_ProDKin_1
 - -
0.89
 --
S 1374 LSNKELKPQKSVVSDLEADDV - 17081983
HTP
0.27
 - -
0.77
 --
S 1374 LSNKELKPQKSVVSDLEADDV - 16964243
HTP
0.27
 - -
0.77
 --
S 1374 LSNKELKPQKSVVSDLEADDV - 17287340
HTP
0.27
 - -
0.77
 --
S 1374 LSNKELKPQKSVVSDLEADDV - 18669648
HTP
0.27
 - -
0.77
 --
S 1377 KELKPQKSVVSDLEADDVKGS - 9761967
LTP
0.43
 MOD_CK2_1
 - -
0.77
 --
S 1377 KELKPQKSVVSDLEADDVKGS CK2_group 7961967
LTP
0.43
 MOD_CK2_1
 - -
0.77
 --
S 1377 KELKPQKSVVSDLEADDVKGS CK2_alpha 7961967
LTP
0.43
 MOD_CK2_1
 - -
0.77
 --
S 1377 KELKPQKSVVSDLEADDVKGS - 17081983
HTP
0.43
 MOD_CK2_1
 - -
0.77
 --
S 1377 KELKPQKSVVSDLEADDVKGS - 16964243
HTP
0.43
 MOD_CK2_1
 - -
0.77
 --
S 1377 KELKPQKSVVSDLEADDVKGS - 17287340
HTP
0.43
 MOD_CK2_1
 - -
0.77
 --
S 1377 KELKPQKSVVSDLEADDVKGS - 18669648
HTP
0.43
 MOD_CK2_1
 - -
0.77
 --
S 1387 SDLEADDVKGSVPLSSSPPAT - 16565220
HTP
0.66
 - -
0.83
 --
S 1391 ADDVKGSVPLSSSPPATHFPD - 18669648
HTP
0.21
 - -
0.84
 --
S 1392 DDVKGSVPLSSSPPATHFPDE - 18669648
HTP
0.33
 - -
0.85
 --
S 1393 DVKGSVPLSSSPPATHFPDET CDK1 7635160
LTP
0.19
 MOD_ProDKin_1
 - -
0.86
 --
S 1393 DVKGSVPLSSSPPATHFPDET MAPK1 7635160
LTP
0.19
 MOD_ProDKin_1
 - -
0.86
 --
S 1393 DVKGSVPLSSSPPATHFPDET MAPK3 7635160
LTP
0.19
 MOD_ProDKin_1
 - -
0.86
 --
S 1393 DVKGSVPLSSSPPATHFPDET - 16565220
HTP
0.19
 MOD_ProDKin_1
 - -
0.86
 --
S 1393 DVKGSVPLSSSPPATHFPDET - 17081983
HTP
0.19
 MOD_ProDKin_1
 - -
0.86
 --
S 1393 DVKGSVPLSSSPPATHFPDET - 18220336
HTP
0.19
 MOD_ProDKin_1
 - -
0.86
 --
S 1393 DVKGSVPLSSSPPATHFPDET - 18669648
HTP
0.19
 MOD_ProDKin_1
 - -
0.86
 --
T 1397 SVPLSSSPPATHFPDETEITN - 18669648
HTP
0.08
 - -
0.86
 --
S 1449 KGTKRDPALNSGVSQKPDPAK - 18669648
HTP
0.51
 - DTHCT
0.90
 --
S 1452 KRDPALNSGVSQKPDPAKTKN - 18669648
HTP
0.62
 - DTHCT
0.90
 --
S 1469 KTKNRRKRKPSTSDDSDSNFE - 18669648
HTP
0.16
 - DTHCT
0.85
 --
T 1470 TKNRRKRKPSTSDDSDSNFEK - 18669648
HTP
0.08
 - DTHCT
0.82
 --
S 1471 KNRRKRKPSTSDDSDSNFEKI - 18669648
HTP
0.53
 - DTHCT
0.81
 --
S 1474 RKRKPSTSDDSDSNFEKIVSK - 15302935
HTP
0.85
 - DTHCT
0.75
 --
S 1474 RKRKPSTSDDSDSNFEKIVSK - 18669648
HTP
0.85
 - DTHCT
0.75
 --
S 1491 IVSKAVTSKKSKGESDDFHMD - 18669648
HTP
0.42
 - DTHCT
0.63
 --
S 1495 AVTSKKSKGESDDFHMDFDSA - 18669648
HTP
0.34
 - DTHCT
0.66
 --
S 1504 ESDDFHMDFDSAVAPRAKSVR - 18220336
HTP
0.34
 - DTHCT
0.68
 --
S 1504 ESDDFHMDFDSAVAPRAKSVR - 18669648
HTP
0.34
 - DTHCT
0.68
 --
S 1525 AKKPIKYLEESDEDDLF     - 9761967
LTP
0.95
 - -
0.51
 --
S 1525 AKKPIKYLEESDEDDLF     CK2_group 7961967
LTP
0.95
 - -
0.51
 --
S 1525 AKKPIKYLEESDEDDLF     CK2_alpha 7961967
LTP
0.95
 - -
0.51
 --
S 1525 AKKPIKYLEESDEDDLF     - 17081983
HTP
0.95
 - -
0.51
 --
S 1525 AKKPIKYLEESDEDDLF     - 16964243
HTP
0.95
 - -
0.51
 --
S 1525 AKKPIKYLEESDEDDLF     - 18669648
HTP
0.95
 - -
0.51
 --

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