Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P15127 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-60761   IRS1_RAT
MINT-60762   IRS2_MOUSE
MINT-6763556   PTN1_HUMAN
MINT-6793537   INSR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin binding,
metal ion binding,
3-phosphoinositide-dependent protein kinase binding,
insulin receptor substrate binding,
lipoic acid binding,
ATP binding,
protein phosphatase binding,
insulin receptor activity,
protein complex binding		 microsome,
endosome,
cytosol,
synapse,
soluble fraction,
nucleus		 fat cell differentiation,
negative regulation of transporter activity,
positive regulation of glycoprotein biosynthetic process,
glucose homeostasis,
response to activity,
response to protein stimulus,
response to estradiol stimulus,
regulation of hydrogen peroxide metabolic process,
protein heterotetramerization,
response to glucose stimulus,
response to tumor necrosis factor,
response to testosterone stimulus,
protein amino acid autophosphorylation,
negative regulation of gene expression,
peptidyl-tyrosine phosphorylation,
response to vitamin D,
response to glucocorticoid stimulus,
response to manganese ion,
response to ethanol,
negative regulation of protein amino acid phosphorylation
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 1376 NGGKKNGRVLTLPRSNPS    PKC_group 1956339
LTP
0.31
 - -
0.72
 - low

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