Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Tyrosine-protein phosphatase, non-receptor type 1 (Protein tyrosine phosphatase 1B)

Seq-ID:

P18031 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-51115   PPIP1_HUMAN
MINT-73489   CADH2_HUMAN
MINT-6744190   CSK21_HUMAN
MINT-6761890   GSK3B_HUMAN
MINT-6761899   ESR1_HUMAN
MINT-6762163   IKBA_HUMAN
MINT-6762380   PGFRB_HUMAN
MINT-6762549   PAXI_MOUSE
MINT-6762573   FAK1_MOUSE
MINT-6762866   IRS1_RAT
MINT-6763504   BCAR1_MOUSE
MINT-6763556   INSR_RAT
MINT-6764602   JAK2_HUMAN
MINT-6764613   STAT3_HUMAN
MINT-6764665   TRPV6_HUMAN
MINT-6764866   CAV1_HUMAN
MINT-6765163   PIAS1_HUMAN
MINT-6765185   SUMO1_HUMAN
MINT-6765318   CTND1_MOUSE
MINT-6765333   LPP_MOUSE
MINT-6765355   SRC8_MOUSE
MINT-6765370   ZO1_MOUSE
MINT-6765383   PLCG1_MOUSE
MINT-6765422   DOK1_MOUSE
MINT-6765439   EGFR_MOUSE
MINT-6765460   PGFRB_MOUSE
MINT-6787689   MET_HUMAN
MINT-6787710   ABL1_HUMAN
MINT-6793324   B3AT_HUMAN
MINT-6793358   EGFR_HUMAN
MINT-6793387   CAN1_HUMAN
MINT-6793394   CAN2_HUMAN
MINT-6793439   IRS1_MOUSE
MINT-6793452   INSR_MOUSE
MINT-6793484   BCAR1_HUMAN
MINT-6793722   AKT1_MOUSE
MINT-6793745   IRS1_HUMAN
MINT-6793782   TYK2_HUMAN
MINT-6793941   NTRK1_HUMAN
MINT-6793957   NTRK3_HUMAN
MINT-6793973   LTK_HUMAN
MINT-6793989   STA5A_HUMAN
MINT-6794005   STA5B_HUMAN
MINT-6794135   LAT_HUMAN
MINT-6794748   EPOR_HUMAN
MINT-6794792   GRB2_HUMAN
MINT-6794817   ITB3_HUMAN
MINT-6794878   ACTS_HUMAN
MINT-6794892   FAK1_HUMAN
MINT-6794946   INSR_HUMAN
MINT-6794972   KPCG_HUMAN
MINT-6795050   JAK2_MOUSE
MINT-6795199   SRC8_HUMAN
MINT-6795447   SRC_HUMAN
MINT-6796717   PLD2_HUMAN
MINT-6797067   CLK2_HUMAN
MINT-6797829   GHR_HUMAN
MINT-6799814   ROS_HUMAN
MINT-6800783   IGF1R_HUMAN
MINT-7972220   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, zinc ion binding	cytosol, endoplasmic reticulum membrane	negative regulation of insulin receptor signaling pathway, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	20	IDKSGSWAAIYQDIRHEASDF	-	15592455	HTP	0.99		-	PTPc	0.30	2CM2	8.73%
S	50	NKNRNRYRDVSPFDHSRIKLH	PKB_group	11579209	LTP	0.89		-	PTPc	0.45	2CM2	4.10%
S	50	NKNRNRYRDVSPFDHSRIKLH	CLK1	10480872	LTP	0.89		-	PTPc	0.45	2CM2	4.10%
Y	66	RIKLHQEDNDYINASLIKMEE	-	11106648	LTP	1.00		-	PTPc	0.36	2CM2	0.00%
Y	66	RIKLHQEDNDYINASLIKMEE	-	8999839	LTP	1.00		-	PTPc	0.36	2CM2	0.00%
Y	66	RIKLHQEDNDYINASLIKMEE	EGFR	9355745	LTP	1.00		-	PTPc	0.36	2CM2	0.00%
Y	152	LTLISEDIKSYYTVRQLELEN	INSR	11106648	LTP	0.95		-	PTPc_DSPc	0.14	2CM2	56.33%
Y	153	TLISEDIKSYYTVRQLELENL	INSR	11106648	LTP	1.00		-	PTPc_DSPc	0.17	2CM2	13.10%
S	352	KDCPIKEEKGSPLNAAPYGIE	-	8491187	LTP	0.32		-	-	0.54	-	-
S	378	TEVRSRVVGGSLRGAQAASPA	PKC_group	8491187	LTP	0.06		-	-	0.63	-	-
S	378	TEVRSRVVGGSLRGAQAASPA	PKC_alpha	8491187	LTP	0.06		-	-	0.63	-	-
S	386	GGSLRGAQAASPAKGEPSLPE	CDK_group	8491187	LTP	0.00	MOD_CDK_SPxK_1	-	-	0.75	-	-
S	386	GGSLRGAQAASPAKGEPSLPE	CDK1	8491187	LTP	0.00	MOD_CDK_SPxK_1	-	-	0.75	-	-