Substrate: P1/eIF-2A protein kinase (Serine/threonine kinase)
Seq-ID: P19525 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14552   CDC42_HUMAN
MINT-3089429   NPM_HUMAN
MINT-6740644   IF2A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
eukaryotic translation initiation factor 2alpha kinase activity,
double-stranded RNA binding,
protein phosphatase type 2A regulator activity,
ATP binding,
protein binding		 intracellular protein amino acid autophosphorylation,
interspecies interaction between organisms,
negative regulation of osteoblast proliferation,
response to virus
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 83 EILNKEKKAVSPLLLTTTNSS EIF2AK2 11152499
LTP
1.00
 - -
0.39
 --
S 83 EILNKEKKAVSPLLLTTTNSS - 18669648
HTP
1.00
 - -
0.39
 --
T 88 EKKAVSPLLLTTTNSSEGLSM EIF2AK2 11152499
LTP
0.18
 - -
0.42
 --
T 89 KKAVSPLLLTTTNSSEGLSMG EIF2AK2 11152499
LTP
0.93
 - -
0.41
 --
T 90 KAVSPLLLTTTNSSEGLSMGN EIF2AK2 11152499
LTP
1.00
 - -
0.39
 --
T 90 KAVSPLLLTTTNSSEGLSMGN - 18669648
HTP
1.00
 - -
0.39
 --
Y 101 NSSEGLSMGNYIGLINRIAQK - 16373505
LTP
1.00
 - DSRM
0.33
 --
Y 162 EAKQLAAKLAYLQILSEETSV - 16373505
LTP
0.97
 - DSRM
0.30
 --
S 242 LRNNQRKAKRSLAPRFDLPDM EIF2AK2 9528799
LTP
0.11
 - -
0.55
 --
S 242 LRNNQRKAKRSLAPRFDLPDM EIF2AK2 8887659
LTP
0.11
 - -
0.55
 --
S 242 LRNNQRKAKRSLAPRFDLPDM EIF2AK2 11152499
LTP
0.11
 - -
0.55
 --
T 255 PRFDLPDMKETKYTVDKRFGM EIF2AK2 9528799
LTP
0.19
 - -
0.38
 --
T 255 PRFDLPDMKETKYTVDKRFGM EIF2AK2 8887659
LTP
0.19
 - -
0.38
 --
T 255 PRFDLPDMKETKYTVDKRFGM EIF2AK2 11152499
LTP
0.19
 - -
0.38
 --
T 258 DLPDMKETKYTVDKRFGMDFK EIF2AK2 11337501
LTP
1.00
 - -
0.38
 2A19 18.49%
T 258 DLPDMKETKYTVDKRFGMDFK EIF2AK2 9528799
LTP
1.00
 - -
0.38
 2A19 18.49%
T 258 DLPDMKETKYTVDKRFGMDFK EIF2AK2 8887659
LTP
1.00
 - -
0.38
 2A19 18.49%
Y 293 KAKHRIDGKTYVIKRVKYNNE - 16373505
LTP
1.00
 - STYKc
0.33
 2A19 10.48%
T 446 VTSLKNDGKRTRSKGTLRYMS EIF2AK2 11337501
LTP
1.00
 - STYKc
0.44
 2A19 54.11%
T 451 NDGKRTRSKGTLRYMSPEQIS EIF2AK2 11337501
LTP
1.00
 - STYKc
0.52
 2A19 69.86%
S 456 TRSKGTLRYMSPEQISSQDYG - 18669648
HTP
1.00
 - STYKc
0.46
 2A19 0.00%

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