Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   LCK_HUMAN
MINT-15716   CRK_HUMAN
MINT-16022   CD2AP_HUMAN
MINT-16347   LYN_HUMAN
MINT-16846   LCP2_HUMAN
MINT-17062   FCGR1_HUMAN
MINT-17932   NCK1_HUMAN
MINT-50666   FYN_HUMAN
MINT-50717   ABL1_HUMAN
MINT-50722   CRKL_HUMAN
MINT-58331   ITCH_HUMAN
MINT-60970   RET_HUMAN
MINT-60973   EGFR_HUMAN
MINT-60978   SHC1_HUMAN
MINT-68500   P85A_HUMAN
MINT-2837344   PLCG1_BOVIN
MINT-4299918   ASAP1_HUMAN
MINT-6169713   SPY1_HUMAN
MINT-6170244   SH3G2_HUMAN
MINT-6538940   SPY4_HUMAN
MINT-6538977   KSYK_HUMAN
MINT-6539587   MET_HUMAN
MINT-6539601   SPY2_HUMAN
MINT-6539646   VGFR1_HUMAN
MINT-6539679   RON_HUMAN
MINT-6539730   SRC_HUMAN
MINT-7040249   GRB2_HUMAN
MINT-7046364   ITSN1_HUMAN
MINT-7103623   MK08_HUMAN
MINT-7211864   ARHG7_HUMAN
MINT-7214822   FYN_MOUSE
MINT-7218352   SH3K1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
ubiquitin-protein ligase activity		 cytosol,
nucleus		 epidermal growth factor receptor signaling pathway,
positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 337 ALIDGFREGFYLFPDGRNQNP - 10608804
LTP
1.00
 CRKL SH2;
CRK SH2;
PIK3R2 SH2		 Cbl_N3
0.18
 1YVH 9.61%
Y 368 QDHIKVTQEQYELYCEMGSTF - 15117950
LTP
1.00
 - -
0.23
 1FBV 3.49%
Y 371 IKVTQEQYELYCEMGSTFQLC - 10635327
LTP
1.00
 PIK3R1 SH2 -
0.11
 1FBV 5.24%
Y 371 IKVTQEQYELYCEMGSTFQLC INSR 11997497
LTP
1.00
 PIK3R1 SH2 -
0.11
 1FBV 5.24%
S 452 LLRQGAEGAPSPNYDDDDDER - 18669648
HTP
0.18
 - -
0.86
 --
Y 552 LPPPPPPDRPYSVGAESRPQR - 15951569
HTP
0.04
 Fyn SH2;
GRB2 SH2		 -
0.94
 --
S 667 PECDHPKIKPSSSANAIYSLA - 16094384
HTP
0.50
 - -
0.53
 --
S 669 CDHPKIKPSSSANAIYSLAAR - 12522270
HTP
0.27
 - -
0.53
 --
S 669 CDHPKIKPSSSANAIYSLAAR - 15144186
HTP
0.27
 - -
0.53
 --
Y 674 IKPSSSANAIYSLAARPLPVP - 12522270
HTP
0.25
 CRKL SH2;
PLCG1 SH2		 -
0.55
 --
Y 674 IKPSSSANAIYSLAARPLPVP - 15144186
HTP
0.25
 CRKL SH2;
PLCG1 SH2		 -
0.55
 --
Y 674 IKPSSSANAIYSLAARPLPVP - 15592455
HTP
0.25
 CRKL SH2;
PLCG1 SH2		 -
0.55
 --
Y 674 IKPSSSANAIYSLAARPLPVP - 15922744
LTP
0.25
 CRKL SH2;
PLCG1 SH2		 -
0.55
 --
S 675 KPSSSANAIYSLAARPLPVPK - 16094384
HTP
0.43
 - -
0.55
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP Fyn 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP SYK 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP Yes 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 9102067
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 12522270
HTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 10829062
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 15922744
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 774 PEESENEDDGYDVPKPPVPAV Fyn 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV SYK 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV Yes 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 12522270
HTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 12604776
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 10829062
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 15922744
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
S 900 NILREFVSISSPAHVAT     - 16964243
HTP
0.68
 - -
0.39
 --
S 900 NILREFVSISSPAHVAT     - 18669648
HTP
0.68
 - -
0.39
 --

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