Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Tristetraproline (tristetraproline (TTP) (TIS11A) (TIS11) (ZFP-36) (from PhosphoBase))

Seq-ID:

P22893 [Mus musculus]

Download:

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, AU-rich element binding, mRNA binding, zinc ion binding	cytosol, nucleus	negative regulation of myeloid cell differentiation, negative regulation of inflammatory response, nuclear-transcribed mRNA poly(A) tail shortening, regulation of mRNA stability, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, RNA destabilization, intracellular protein kinase cascade

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	52	VTSRLTGRSTSLVEGRSCGWV	MAPKAPK2	14688255	LTP	1.00		YWHAB 14-3-3	-	0.45	-	low
S	80	PLAPRPGPELSPSPTSPTATP	MAPKAPK2	14688255	LTP	0.62	MOD_ProDKin_1	-	-	0.86	-	low
S	82	APRPGPELSPSPTSPTATPTT	MAPKAPK2	14688255	LTP	0.62	MOD_ProDKin_1	-	-	0.89	-	low
S	85	PGPELSPSPTSPTATPTTSSR	MAPKAPK2	14688255	LTP	0.51	MOD_ProDKin_1	-	-	0.87	-	low
S	178	GQPHVLRQSISFSGLPSGRRS	MAPKAPK2	14688255	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAZ 14-3-3	-	0.65	-	low
S	220	SPPPPGDLPLSPSAFSAAPGT	MAPK_group	7768935	LTP	0.66	MOD_ProDKin_1	-	-	0.77	-	low
T	250	ACCPSCRRSTTPSTIWGPLGG	MAPKAPK2	14688255	LTP	0.33	MOD_ProDKin_1	-	-	0.43	-	low
S	316	PRRLPIFNRISVSE	MAPKAPK2	14688255	LTP	1.00		-	-	0.48	-	low