Substrate: PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)
Seq-ID: P27986 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16109   ARAF_HUMAN
MINT-17501   SHC1_HUMAN
MINT-19009   CDC42_HUMAN
MINT-56732   KSYK_HUMAN
MINT-56734   KSYK_MOUSE
MINT-65974   GRB2_HUMAN
MINT-66003   LCK_HUMAN
MINT-68496   GAB2_HUMAN
MINT-68500   CBL_HUMAN
MINT-68735   IRS1_HUMAN
MINT-74606   EGFR_HUMAN
MINT-74610   ERBB2_HUMAN
MINT-74617   ERBB3_HUMAN
MINT-1893011   GAB1_HUMAN
MINT-2840114   TLR3_HUMAN
MINT-3378272   SEPT2_HUMAN
MINT-6762880   IRS1_RAT
MINT-7103574   FLT3_HUMAN
MINT-7103638   MK08_HUMAN
MINT-7103655   CRKL_HUMAN
MINT-7251262   ICAL_HUMAN
MINT-7251286   SNX17_HUMAN
MINT-7251334   DAB2_HUMAN
MINT-7251346   CDC27_HUMAN
MINT-7251370   FLNA_HUMAN
MINT-7251382   SYNJ2_HUMAN
MINT-7251406   CSDE1_HUMAN
MINT-7251418   ABL1_HUMAN
MINT-7251430   SUV92_HUMAN
MINT-7251442   VP13A_HUMAN
MINT-7251454   FLNB_HUMAN
MINT-7251526   SOS1_HUMAN
MINT-7251538   ASAP2_HUMAN
MINT-7251550   LIPA3_HUMAN
MINT-7251562   AKAP2_HUMAN
MINT-7251574   ARHGB_HUMAN
MINT-7251598   PHAR2_HUMAN
MINT-7251610   DLGP4_HUMAN
MINT-7251622   ELK3_HUMAN
MINT-7251658   BRCA1_HUMAN
MINT-7251706   CKAP5_HUMAN
MINT-7251718   RRAS_HUMAN
MINT-7251730   ECT2_HUMAN
MINT-7251754   TPX2_HUMAN
MINT-7251766   JAK2_HUMAN
MINT-7251778   ASAP1_HUMAN
MINT-7251790   FLNC_HUMAN
MINT-7251802   DNLI3_HUMAN
MINT-7251814   TGON2_HUMAN
MINT-7251838   SHAN2_HUMAN
MINT-7251850   KI13A_HUMAN
MINT-7251862   ABL2_HUMAN
MINT-7251886   BRPF3_HUMAN
MINT-7251898   SH3K1_HUMAN
MINT-7251934   MYRIP_HUMAN
MINT-7251982   DAG1_HUMAN
MINT-7251994   STF1_HUMAN
MINT-7252006   P3C2B_HUMAN
MINT-7252018   SNX8_HUMAN
MINT-7252030   BRD4_HUMAN
MINT-7252078   MINT_HUMAN
MINT-7252126   PLCG2_HUMAN
MINT-7252150   MAP4_HUMAN
MINT-7252174   MYLK_HUMAN
MINT-7252186   PEBP1_HUMAN
MINT-7252234   CAF1A_HUMAN
MINT-7252258   DTBP1_HUMAN
MINT-7252270   NELFB_HUMAN
MINT-7252282   AKAP6_HUMAN
MINT-7252294   FANCA_HUMAN
MINT-7252318   GHR_HUMAN
MINT-7252330   M4K1_HUMAN
MINT-7252342   RPGF1_HUMAN
MINT-7296136   SRC_HUMAN
MINT-7306624   LCP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ErbB-3 class receptor binding,
insulin-like growth factor receptor binding,
phosphoinositide 3-kinase regulator activity,
insulin binding,
insulin receptor binding,
insulin receptor substrate binding,
phosphatidylinositol binding,
protein phosphatase binding		 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex phosphoinositide 3-kinase cascade,
insulin-like growth factor receptor signaling pathway,
phosphoinositide phosphorylation,
interspecies interaction between organisms,
positive regulation of establishment of protein localization in plasma membrane,
insulin receptor signaling pathway,
positive regulation of glucose import,
growth hormone receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 RDASTKMHGDYTLTLRKGGNN INSR 8385099
LTP
0.95
 - SH2
0.45
 2IUG 6.99%
Y 452 IEAVGKKLHEYNTQFQEKSRE - 18083107
HTP
1.00
 - -
0.44
 2RD0 16.59%
Y 467 QEKSREYDRLYEEYTRTSQEI - 18083107
HTP
1.00
 - -
0.46
 2RD0 44.98%
Y 556 EEDLKKQAAEYREIDKRMNSI - 18083107
HTP
0.15
 - COIL
0.48
 2RD0 24.02%
Y 580 LIQLRKTRDQYLMWLTQKGVR INSR 8385099
LTP
1.00
 - -
0.29
 2RD0 55.02%
Y 580 LIQLRKTRDQYLMWLTQKGVR - 18083107
HTP
1.00
 - -
0.29
 2RD0 55.02%
Y 607 WLGNENTEDQYSLVEDDEDLP SRC 8385099
LTP
1.00
 - -
0.55
 --
Y 607 WLGNENTEDQYSLVEDDEDLP INSR 8385099
LTP
1.00
 - -
0.55
 --
Y 607 WLGNENTEDQYSLVEDDEDLP - 15592455
HTP
1.00
 - -
0.55
 --
S 608 LGNENTEDQYSLVEDDEDLPH PIK3CA 9446654
LTP
1.00
 - -
0.58
 --
S 608 LGNENTEDQYSLVEDDEDLPH - 8313897
LTP
1.00
 - -
0.58
 --
S 608 LGNENTEDQYSLVEDDEDLPH PIK3CA 14729945
LTP
1.00
 - -
0.58
 --
T 623 DEDLPHHDEKTWNVGSSNRNK - 17081983
HTP
0.94
 - SH2
0.66
 1H9O 9.59%
Y 688 GYGFAEPYNLYSSLKELVLHY - 9461588
LTP
1.00
 PIK3R1 SH2 SH2
0.19
 1H9O 15.72%
Y 688 GYGFAEPYNLYSSLKELVLHY - 11337495
LTP
1.00
 PIK3R1 SH2 SH2
0.19
 1H9O 15.72%

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