Substrate: Shc ( Adaptor molecule)
Seq-ID: P29353 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13959   DDR2_HUMAN
MINT-14688   GAB2_HUMAN
MINT-15243   LYN_HUMAN
MINT-15425   FYN_HUMAN
MINT-15946   FCGR1_HUMAN
MINT-16179   SHIP1_HUMAN
MINT-16513   LCP2_HUMAN
MINT-17269   SRC_CHICK
MINT-17501   P85A_HUMAN
MINT-49636   CADH5_HUMAN
MINT-49637   VGFR2_HUMAN
MINT-49660   A4_HUMAN
MINT-60978   CBL_HUMAN
MINT-60980   ZAP70_HUMAN
MINT-60981   RET_HUMAN
MINT-61536   ERBB4_HUMAN
MINT-61537   GRB2_HUMAN
MINT-74732   EGFR_HUMAN
MINT-74737   ERBB2_HUMAN
MINT-74738   ERBB3_HUMAN
MINT-1782423   SOS1_HUMAN
MINT-2738306   JAK2_MOUSE
MINT-7714840   IQGA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
phospholipid binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 mitochondrial matrix,
Shc-EGFR complex,
cytosol		 positive regulation of DNA replication,
positive regulation of cell proliferation,
regulation of growth,
regulation of epidermal growth factor receptor activity,
epidermal growth factor receptor signaling pathway,
activation of MAPK activity,
Ras protein signal transduction,
insulin receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 36 SGSTPPEELPSPSASSLGPIL - 15837797
LTP
0.12
 - -
0.92
 --
S 54 PILPPLPGDDSPTTLCSFFPR - 16251354
LTP
0.27
 - -
0.67
 --
S 139 LGGEEWTRHGSFVNKPTRGWL - 18669648
HTP
0.93
 - -
0.57
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 11075717
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 9121430
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP SYK 9710204
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP ZAP70 9710204
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 10891441
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 11687594
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 15592455
HTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP FLT4 9927207
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 350 EEEEPPDHQYYNDFPGKEPPL - 11075717
LTP
1.00
 GRB2 SH2;
INPP5D SH2		 -
0.85
 --
Y 350 EEEEPPDHQYYNDFPGKEPPL - 9121430
LTP
1.00
 GRB2 SH2;
INPP5D SH2		 -
0.85
 --
Y 350 EEEEPPDHQYYNDFPGKEPPL SYK 9710204
LTP
1.00
 GRB2 SH2;
INPP5D SH2		 -
0.85
 --
Y 350 EEEEPPDHQYYNDFPGKEPPL ZAP70 9710204
LTP
1.00
 GRB2 SH2;
INPP5D SH2		 -
0.85
 --
Y 350 EEEEPPDHQYYNDFPGKEPPL - 15592455
HTP
1.00
 GRB2 SH2;
INPP5D SH2		 -
0.85
 --
Y 350 EEEEPPDHQYYNDFPGKEPPL FLT4 9927207
LTP
1.00
 GRB2 SH2;
INPP5D SH2		 -
0.85
 --
T 386 AARPTAPNAQTPSHLGATLPV - 16251354
LTP
0.22
 - -
0.87
 --
S 426 CPGRELFDDPSYVNVQNLDKA - 18669648
HTP
0.10
 - -
0.65
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 11075717
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR SYK 9710204
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR ZAP70 9710204
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 8610109
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 9741627
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 12522270
HTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 15592455
HTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR FLT4 9927207
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 18083107
HTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 18669648
HTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --

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