Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Nitric-oxide synthase, endothelial (Nitric-oxide synthase, endothelial)

Seq-ID:

P29474 [Homo sapiens]

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Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

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Molecular Function	Cellular Component	Biological Process
arginine binding, actin monomer binding, heme binding, cadmium ion binding, NADP or NADPH binding, FAD binding, calmodulin binding, nitric-oxide synthase activity, tetrahydrobiopterin binding, FMN binding	Golgi membrane, caveola, cytosol, cytoskeleton	regulation of blood vessel size, positive regulation of vasodilation, oxidation reduction, blood vessel remodeling, regulation of systemic arterial blood pressure by endothelin, anti-apoptosis, response to heat, positive regulation of guanylate cyclase activity, arginine catabolic process, negative regulation of muscle hyperplasia, positive regulation of angiogenesis, nitric oxide biosynthetic process, smooth muscle hyperplasia, endothelial cell migration, negative regulation of platelet activation, response to fluid shear stress, mitochondrion organization

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	81	VKNWEVGSITYDTLSAQAQQD	-	18083107	HTP	0.16		-	-	0.51	1M9M	55.02%
T	495	AKGTGITRKKTFKEVANAVKI	-	16126727	LTP	0.05		-	-	0.33	-	-
S	615	QHKSYKIRFNSISCSDPLVSS	PKB_group	12171920	LTP	0.23		-	Flavodoxin_1	0.19	-	-
S	633	VSSWRRKRKESSNTDSAGALG	PKA_group	12171920	LTP	0.04	MOD_PKA_1	-	Flavodoxin_1	0.47	-	-
S	1177	QEVTSRIRTQSFSLQERQLRG	-	16126727	LTP	0.16	MOD_PKB_1	-	-	0.41	-	-
S	1177	QEVTSRIRTQSFSLQERQLRG	PKB_group	10376603	LTP	0.16	MOD_PKB_1	-	-	0.41	-	-
S	1177	QEVTSRIRTQSFSLQERQLRG	PKB_group	12446767	LTP	0.16	MOD_PKB_1	-	-	0.41	-	-
S	1177	QEVTSRIRTQSFSLQERQLRG	PKB_group	12791703	LTP	0.16	MOD_PKB_1	-	-	0.41	-	-
S	1177	QEVTSRIRTQSFSLQERQLRG	PKB_group	16043647	LTP	0.16	MOD_PKB_1	-	-	0.41	-	-
S	1179	VTSRIRTQSFSLQERQLRGAV	PKB_group	12501214	LTP	0.08	MOD_PKB_1	-	-	0.37	-	-