Substrate: cdc25c (M-phase inducer phosphatase 3)
Seq-ID: P30307 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16690   PLK1_HUMAN
MINT-3294433   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
WW domain binding		 cytosol,
nucleoplasm		 regulation of cyclin-dependent protein kinase activity,
cell division,
traversing start control point of mitotic cell cycle,
protein amino acid dephosphorylation,
regulation of mitosis,
mitosis,
interspecies interaction between organisms,
DNA replication,
cell proliferation
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 17 SSTREEGSSGSGPSFRSNQRK - 18669648
HTP
0.15
 - -
0.75
 - low
S 38 MLNLLLERDTSFTVCPDVPRT - 18669648
HTP
1.00
 - -
0.41
 - low
T 48 SFTVCPDVPRTPVGKFLGDSA CDK1 8119945
LTP
0.19
 PIN1 WW -
0.44
 - low
T 48 SFTVCPDVPRTPVGKFLGDSA - 18669648
HTP
0.19
 PIN1 WW -
0.44
 - low
S 57 RTPVGKFLGDSANLSILSGGT - 18669648
HTP
0.13
 - -
0.47
 - low
S 61 GKFLGDSANLSILSGGTPKRC - 18669648
HTP
0.24
 - -
0.40
 - low
S 64 LGDSANLSILSGGTPKRCLDL - 18669648
HTP
0.13
 - -
0.38
 - low
T 67 SANLSILSGGTPKRCLDLSNL CDK1 8119945
LTP
0.24
 MOD_CDK_SPxK_1
 PIN1 WW -
0.40
 - low
T 67 SANLSILSGGTPKRCLDLSNL - 18669648
HTP
0.24
 MOD_CDK_SPxK_1
 PIN1 WW -
0.40
 - low
S 122 MNHDQHLMKCSPAQLLCSTPN CDK1 8119945
LTP
0.06
 - M-inducer_phosp
0.49
 - low
T 130 KCSPAQLLCSTPNGLDRGHRK CDK1 8119945
LTP
0.20
 PLK1 PBD M-inducer_phosp
0.55
 - low
S 148 HRKRDAMCSSSANKENDNGNL - 18669648
HTP
0.20
 - M-inducer_phosp
0.71
 - low
S 168 LVDSEMKYLGSPITTVPKLDK CDK1 8119945
LTP
1.00
 - M-inducer_phosp
0.53
 - low
S 168 LVDSEMKYLGSPITTVPKLDK - 12742231
LTP
1.00
 - M-inducer_phosp
0.53
 - low
S 168 LVDSEMKYLGSPITTVPKLDK - 16964243
HTP
1.00
 - M-inducer_phosp
0.53
 - low
S 168 LVDSEMKYLGSPITTVPKLDK - 22067460
HTP
1.00
 - M-inducer_phosp
0.53
 - low
S 191 NLGEDQAEEISDELMEFSLKD PLK3 14968113
LTP
0.21
 - M-inducer_phosp
0.57
 - low
S 198 EEISDELMEFSLKDQEAKVSR PLK1 11897663
LTP
0.14
 MOD_PLK
 - M-inducer_phosp
0.49
 - low
S 198 EEISDELMEFSLKDQEAKVSR PLK3 14968113
LTP
0.14
 MOD_PLK
 - M-inducer_phosp
0.49
 - low
S 214 AKVSRSGLYRSPSMPENLNRP CDK1 8119945
LTP
1.00
 - M-inducer_phosp
0.67
 - low
S 214 AKVSRSGLYRSPSMPENLNRP - 12766774
LTP
1.00
 - M-inducer_phosp
0.67
 - low
S 216 VSRSGLYRSPSMPENLNRPRL CHK2 10744722
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low
S 216 VSRSGLYRSPSMPENLNRPRL - 15629715
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low
S 216 VSRSGLYRSPSMPENLNRPRL CHK2 9836640
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low
S 216 VSRSGLYRSPSMPENLNRPRL BRSK1 9543386
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low

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