Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
caveola,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
positive regulation of insulin receptor signaling pathway,
positive regulation of fatty acid beta-oxidation,
phosphoinositide 3-kinase cascade,
negative regulation of insulin secretion,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 24 RKVGYLRKPKSMHKRFFVLRA CK2_group 8349691
LTP
1.00
 - PH
0.26
 1QQG 44.26%
S 24 RKVGYLRKPKSMHKRFFVLRA PLK1 15849359
LTP
1.00
 - PH
0.26
 1QQG 44.26%
Y 46 SEAGGPARLEYYENEKKWRHK - 15592455
HTP
1.00
 - PH
0.49
 1QQG 9.61%
Y 46 SEAGGPARLEYYENEKKWRHK - 18083107
HTP
1.00
 - PH
0.49
 1QQG 9.61%
S 268 RAMSDEFRPRSKSQSSSNCSN IKK_group 12351658
LTP
1.00
 - -
0.69
 --
S 270 MSDEFRPRSKSQSSSNCSNPI IKK_group 12351658
LTP
1.00
 YWHAG 14-3-3;
YWHAZ 14-3-3		 -
0.69
 --
S 272 DEFRPRSKSQSSSNCSNPISV IKK_group 12351658
LTP
1.00
 - -
0.67
 --
S 274 FRPRSKSQSSSNCSNPISVPL IKK_group 12351658
LTP
1.00
 - -
0.69
 --
S 307 VGLTRRSRTESITATSPASMV IKK_group 12351658
LTP
1.00
 - -
0.78
 --
S 307 VGLTRRSRTESITATSPASMV PKC_delta 14583092
LTP
1.00
 - -
0.78
 --
S 307 VGLTRRSRTESITATSPASMV - 16099428
LTP
1.00
 - -
0.78
 --
S 307 VGLTRRSRTESITATSPASMV - 15199052
LTP
1.00
 - -
0.78
 --
S 307 VGLTRRSRTESITATSPASMV - 16129690
LTP
1.00
 - -
0.78
 --
S 312 RSRTESITATSPASMVGGKPG IKK_group 12351658
LTP
1.00
 - -
0.80
 --
S 312 RSRTESITATSPASMVGGKPG - 11606564
LTP
1.00
 - -
0.80
 --
S 312 RSRTESITATSPASMVGGKPG - 15199052
LTP
1.00
 - -
0.80
 --
S 323 PASMVGGKPGSFRVRASSDGE PKC_zeta 15516986
LTP
0.05
 - -
0.79
 --
S 323 PASMVGGKPGSFRVRASSDGE - 14583092
LTP
0.05
 - -
0.79
 --
S 323 PASMVGGKPGSFRVRASSDGE PKC_zeta 16129678
LTP
0.05
 - -
0.79
 --
S 341 DGEGTMSRPASVDGSPVSPST IKK_group 12351658
LTP
0.96
 - -
0.90
 --
S 345 TMSRPASVDGSPVSPSTNRTH IKK_group 12351658
LTP
1.00
 - -
0.90
 --
S 348 RPASVDGSPVSPSTNRTHAHR - 16020478
LTP
1.00
 - -
0.90
 --
S 348 RPASVDGSPVSPSTNRTHAHR - 18220336
HTP
1.00
 - -
0.90
 --
S 374 RLHPPLNHSRSIPMPASRCSP - 16020478
LTP
1.00
 YWHAG 14-3-3;
YWHAZ 14-3-3		 -
0.77
 --
S 527 LDNRFRKRTHSAGTSPTITHQ IKK_group 12351658
LTP
1.00
 - -
0.82
 --
T 530 RFRKRTHSAGTSPTITHQKTP - 16020478
LTP
1.00
 - -
0.88
 --
S 531 FRKRTHSAGTSPTITHQKTPS IKK_group 12351658
LTP
1.00
 - -
0.89
 --
S 531 FRKRTHSAGTSPTITHQKTPS - 18220336
HTP
1.00
 - -
0.89
 --
S 574 SGGRLPGHRHSAFVPTRSYPE PKC_delta 15516986
LTP
1.00
 - -
0.80
 --
S 574 SGGRLPGHRHSAFVPTRSYPE - 14583092
LTP
1.00
 - -
0.80
 --
Y 612 DSSTLHTDDGYMPMSPGVAPV - 15001544
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.81
 --
Y 612 DSSTLHTDDGYMPMSPGVAPV - 18083107
HTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.81
 --
S 616 LHTDDGYMPMSPGVAPVPSGR MAPK3 15001544
LTP
0.18
 MOD_ProDKin_1
 - -
0.82
 --
S 616 LHTDDGYMPMSPGVAPVPSGR - 14769130
LTP
0.18
 MOD_ProDKin_1
 - -
0.82
 --
S 629 VAPVPSGRKGSGDYMPMSPKS - 17081983
HTP
0.30
 - -
0.82
 --
Y 632 VPSGRKGSGDYMPMSPKSVSA - 15001544
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.83
 --
Y 632 VPSGRKGSGDYMPMSPKSVSA - 18083107
HTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.83
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 14769130
LTP
1.00
 - -
0.79
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 16099428
LTP
1.00
 - -
0.79
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 15576463
LTP
1.00
 - -
0.79
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 16123357
LTP
1.00
 - -
0.79
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 17081983
HTP
1.00
 - -
0.79
 --
S 639 SGDYMPMSPKSVSAPQQIINP - 14769130
LTP
1.00
 - -
0.73
 --
S 639 SGDYMPMSPKSVSAPQQIINP - 16099428
LTP
1.00
 - -
0.73
 --
S 639 SGDYMPMSPKSVSAPQQIINP - 15576463
LTP
1.00
 - -
0.73
 --
S 639 SGDYMPMSPKSVSAPQQIINP - 16123357
LTP
1.00
 - -
0.73
 --
Y 662 RHPQRVDPNGYMMMSPSGGCS - 15592455
HTP
1.00
 Fyn SH2;
MATK SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.77
 --
S 794 ARHQHLRLSTSSGRLLYAATA SIK 12624099
LTP
1.00
 - -
0.65
 --
S 794 ARHQHLRLSTSSGRLLYAATA AMPK_group 20135346
LTP
1.00
 - -
0.65
 --
S 892 QPLLHPPEPKSPGEYVNIEFG - 16020478
LTP
1.00
 - -
0.79
 --
Y 896 HPPEPKSPGEYVNIEFGSDQS - 11259577
LTP
1.00
 GRB2 SH2;
PTPN11 SH2		 -
0.76
 --
S 1078 GMSAFTRVNLSPNRNQSAKVI - 16503154
LTP
0.30
 - -
0.60
 --
S 1101 DPQGCRRRHSSETFSSTPSAT PKC_theta 15364919
LTP
1.00
 - -
0.78
 --
S 1101 DPQGCRRRHSSETFSSTPSAT - 17081983
HTP
1.00
 - -
0.78
 --
S 1101 DPQGCRRRHSSETFSSTPSAT RSK-1 17709744
LTP
1.00
 - -
0.78
 --
S 1101 DPQGCRRRHSSETFSSTPSAT - 18220336
HTP
1.00
 - -
0.78
 --
T 1111 SETFSSTPSATRVGNTVPFGA - 18220336
HTP
1.00
 - -
0.68
 --
S 1145 SEDVKRHSSASFENVWLRPGE - 16020478
LTP
1.00
 - -
0.61
 --
S 1222 GSGESSSTRRSSEDLSAYASI - 16020478
LTP
0.07
 - -
0.70
 --
S 1223 SGESSSTRRSSEDLSAYASIS - 16020478
LTP
0.11
 - -
0.68
 --

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