Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35569 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58476   NUCL_MOUSE
MINT-6381887   P85A_MOUSE
MINT-6793439   PTN1_HUMAN
MINT-6794075   INSR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
SH2 domain binding		 microsome,
cytosol,
nucleus		 positive regulation of mesenchymal cell proliferation,
positive regulation of cell migration,
protein kinase B signaling cascade,
mammary gland development,
insulin receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 3         MASPPDTDGFSDV - 17242355
HTP
 - - -
0.50
 --
S 267 DEFRPRSKSQSSSSCSNPISV - 12714600
LTP
1.00
 - -
0.66
 --
S 302 VGLTRRSRTESITATSPASMV PKB_group 11701324
LTP
1.00
 MOD_PKB_1
 - -
0.78
 --
S 307 RSRTESITATSPASMVGGKPG - 16055440
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 15994203
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 12714600
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 14998989
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 11160134
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 15314024
LTP
1.00
 - -
0.80
 --
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16129678
LTP
0.05
 - -
0.79
 --
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16099431
LTP
0.05
 - -
0.79
 --
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16055440
LTP
0.05
 - -
0.79
 --
S 324 GKPGSFRVRASSDGEGTMSRP - 17242355
HTP
1.00
 - -
0.83
 --
S 340 TMSRPASVDGSPVSPSTNRTH - 17242355
HTP
1.00
 - -
0.90
 --
S 408 TSDCLFPRRSSASVSGSPSDG - 15485932
LTP
1.00
 - -
0.60
 --
Y 608 DTSNLHTDDGYMPMSPGVAPV - 9395471
LTP
1.00
 PIK3R1 SH2 -
0.80
 --
Y 608 DTSNLHTDDGYMPMSPGVAPV - 15821749
LTP
1.00
 PIK3R1 SH2 -
0.80
 --
S 612 LHTDDGYMPMSPGVAPVPSNR - 15994203
LTP
0.18
 - -
0.81
 --
S 612 LHTDDGYMPMSPGVAPVPSNR - 9395471
LTP
0.18
 - -
0.81
 --
S 612 LHTDDGYMPMSPGVAPVPSNR - 15821749
LTP
0.18
 - -
0.81
 --
S 612 LHTDDGYMPMSPGVAPVPSNR - 10092613
LTP
0.18
 - -
0.81
 --
S 632 RKGNGDYMPMSPKSVSAPQQI ROCK2 16098829
LTP
1.00
 - -
0.79
 --
S 632 RKGNGDYMPMSPKSVSAPQQI - 11287630
LTP
1.00
 - -
0.79
 --
S 635 NGDYMPMSPKSVSAPQQIINP ROCK2 16098829
LTP
1.00
 - -
0.72
 --
S 635 NGDYMPMSPKSVSAPQQIINP - 11287630
LTP
1.00
 - -
0.72
 --
S 635 NGDYMPMSPKSVSAPQQIINP - 15994203
LTP
1.00
 - -
0.72
 --
S 789 ARHQHLRLSSSSGRLRYTATA AMPK_group 11598104
LTP
0.03
 - -
0.75
 --
S 1097 DTQGCRRRHSSETFSAPTRAG - 15364919
LTP
1.00
 - -
0.79
 --
S 1139 SEDVKRHSSASFENVWLRPGD - 17242355
HTP
1.00
 - -
0.64
 --
S 1214 SNEGNSPRRSSEDLSNYASIS - 17242355
HTP
1.00
 - -
0.76
 --

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