Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-45938   ITB2_HUMAN
MINT-45939   ITB3_HUMAN
MINT-60761   INSR_RAT
MINT-6762786   GRB2_HUMAN
MINT-6762811   PTN11_HUMAN
MINT-6762830   PTPRA_HUMAN
MINT-6762866   PTN1_HUMAN
MINT-6762880   P85A_HUMAN
MINT-6762904   CRK_HUMAN
MINT-6795115   INSR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin-like growth factor receptor activity,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
negative regulation of somatostatin secretion,
positive regulation of insulin receptor signaling pathway,
negative regulation of insulin secretion,
protein heterooligomerization,
insulin receptor signaling pathway,
positive regulation of phosphoinositide 3-kinase activity,
positive regulation of phosphorylation,
positive regulation of glucagon secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 99 RDEHFAIAADSEAEQDSWYQA CK2_group 8349691
LTP
0.11
 MOD_CK2_1
 - PH
0.28
 - medium
Y 460 PARGEEELSNYICMGGKGAST INSR 7504175
LTP
1.00
 - -
0.58
 - medium
T 502 GATMGTSPALTGDEAAGAADL CK2_group 8349691
LTP
0.00
 MOD_CK2_1
 - -
0.72
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV - 12220227
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 658 RHPQRVDPNGYMMMSPSGSCS IGF1R 11572799
LTP
1.00
 - -
0.72
 - medium
Y 727 GGKLLPCTGDYMNMSPVGDSN IGF1R 11572799
LTP
1.00
 - -
0.60
 - medium
S 789 ARHQHLRLSSSSGRLRYTATA AMPK_group 11598104
LTP
0.03
 - -
0.77
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 7504175
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP IGF1R 8530377
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 8530377
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 939 APREETGSEEYMNMDLGPGRR IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 7504175
LTP
0.16
 - -
0.64
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ IGF1R 11572799
LTP
0.16
 - -
0.64
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 11572799
LTP
0.16
 - -
0.64
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 7504175
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK IGF1R 11572799
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 11572799
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1222 PRRSSEDLSTYASINFQKQPE INSR 7504175
LTP
0.09
 PTPN11 SH2 -
0.77
 - medium
Y 1222 PRRSSEDLSTYASINFQKQPE - 12220227
LTP
0.09
 PTPN11 SH2 -
0.77
 - medium

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