Substrate: IL-6R (gp130) (gp130 is shared by members of the IL-6 family)
Seq-ID: P40189 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ciliary neurotrophic factor receptor activity,
protein homodimerization activity,
interleukin-27 receptor activity,
ciliary neurotrophic factor receptor binding		 extracellular region,
oncostatin-M receptor complex,
interleukin-6 receptor complex,
extracellular space,
ciliary neurotrophic factor receptor complex		 positive regulation vascular endothelial growth factor production,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of anti-apoptosis,
leukemia inhibitory factor signaling pathway,
response to cytokine stimulus,
negative regulation of interleukin-6-mediated signaling pathway,
positive regulation of tyrosine phosphorylation of Stat1 protein,
positive regulation of adaptive immune response,
ciliary neurotrophic factor-mediated signaling pathway,
positive regulation of T cell proliferation,
positive regulation of osteoblast differentiation,
interleukin-27-mediated signaling pathway,
positive regulation of acute inflammatory response,
positive regulation of cardiac muscle hypertrophy
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 667 DPSKSHIAQWSPHTPPRHNFN - 17081983
HTP
1.00
 - -
0.66
 - medium
S 667 DPSKSHIAQWSPHTPPRHNFN - 18088087
HTP
1.00
 - -
0.66
 - medium
Y 683 RHNFNSKDQMYSDGNFTDVSV - 10661409
LTP
0.20
 - -
0.44
 - medium
Y 759 SSQNTSSTVQYSTVVHSGYRH - 8934572
LTP
1.00
 PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.61
 - medium
Y 759 SSQNTSSTVQYSTVVHSGYRH - 9505191
LTP
1.00
 PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.61
 - medium
Y 767 VQYSTVVHSGYRHQVPSVQVF - 8612579
LTP
1.00
 STAT3 SH2 -
0.45
 - medium
Y 767 VQYSTVVHSGYRHQVPSVQVF - 10661409
LTP
1.00
 STAT3 SH2 -
0.45
 - medium
S 780 QVPSVQVFSRSESTQPLLDSE - 18669648
HTP
1.00
 - -
0.62
 - medium
S 782 PSVQVFSRSESTQPLLDSEER - 15786731
LTP
1.00
 - -
0.66
 - medium
S 782 PSVQVFSRSESTQPLLDSEER - 10811661
LTP
1.00
 - -
0.66
 - medium
T 783 SVQVFSRSESTQPLLDSEERP - 18669648
HTP
1.00
 - -
0.68
 - medium
Y 814 GGDGILPRQQYFKQNCSQHES - 8612579
LTP
1.00
 STAT3 SH2 -
0.61
 - medium
Y 814 GGDGILPRQQYFKQNCSQHES - 10661409
LTP
1.00
 STAT3 SH2 -
0.61
 - medium
S 820 PRQQYFKQNCSQHESSPDISH - 17081983
HTP
0.14
 - -
0.59
 - medium
S 829 CSQHESSPDISHFERSKQVSS - 17081983
HTP
1.00
 - -
0.71
 - medium
T 890 GTEGQVERFETVGMEAATDEG PKC_delta 12361954
LTP
0.58
 - -
0.74
 - medium
Y 905 AATDEGMPKSYLPQTVRQGGY - 8612579
LTP
1.00
 STAT1 SH2;
STAT3 SH2		 -
0.70
 - medium
Y 905 AATDEGMPKSYLPQTVRQGGY - 10661409
LTP
1.00
 STAT1 SH2;
STAT3 SH2		 -
0.70
 - medium
Y 915 YLPQTVRQGGYMPQ        - 8612579
LTP
1.00
 STAT1 SH2;
STAT3 SH2		 -
0.64
 - medium
Y 915 YLPQTVRQGGYMPQ        - 10661409
LTP
1.00
 STAT1 SH2;
STAT3 SH2		 -
0.64
 - medium

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