Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

STAT 1 (Transcription factor)

Seq-ID:

P42224 [Homo sapiens]

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Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-74755 ERBB2_HUMAN
MINT-7264037 CBP_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity, sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm, nucleolus	transcription from RNA polymerase II promoter, activation of caspase activity, I-kappaB kinase/NF-kappaB cascade, interspecies interaction between organisms, regulation of transcription, DNA-dependent, response to virus, tyrosine phosphorylation of STAT protein

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	701	MELDGPKGTGYIKTELISVSE	-	7592750	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	-	15322115	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	JAK2	11438544	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	JAK1	11438544	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	-	10748192	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	SRC	14978237	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	JAK2	14978237	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	JAK1	14978237	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
S	727	LQTTDNLLPMSPEEFDEVSRI	-	7543024	LTP	1.00		-	-	0.53	-	-
S	727	LQTTDNLLPMSPEEFDEVSRI	-	18669648	HTP	1.00		-	-	0.53	-	-