Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Crk (The Crk protein contains a single SH2 and two SH3 domains in the order SH2-SH3-SH3)

Seq-ID:

P46108 [Homo sapiens]

Download:

Interaction Network(s):

STRING

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-15716   CBL_HUMAN
MINT-17467   VAV_HUMAN
MINT-51245   SMAD3_HUMAN
MINT-72620   WASL_HUMAN
MINT-74497   EGFR_HUMAN
MINT-74498   ERBB2_HUMAN
MINT-74500   ERBB3_HUMAN
MINT-2855127   ATX1_HUMAN
MINT-6762904   IRS1_RAT
MINT-6763928   PAXI_HUMAN
MINT-6763936   BCAR1_HUMAN
MINT-7103547   MK08_HUMAN
MINT-7104372   ACK1_HUMAN
MINT-7235318   ABL1_MOUSE
MINT-7253878   SNX17_HUMAN
MINT-7253890   PHAR2_HUMAN
MINT-7253902   FANCA_HUMAN
MINT-7253974   AKAP6_HUMAN
MINT-7254022   MINT_HUMAN
MINT-7254046   AKAP2_HUMAN
MINT-7254082   ICAL_HUMAN
MINT-7254106   ABL1_HUMAN
MINT-7254130   ASAP2_HUMAN
MINT-7254142   FCG2B_HUMAN
MINT-7254154   FCG2C_HUMAN
MINT-7254202   ASAP1_HUMAN
MINT-7254250   DOCK1_HUMAN
MINT-7254262   RRAS_HUMAN
MINT-7254274   SOS1_HUMAN
MINT-7254286   RGS7_HUMAN
MINT-7254334   E41L3_HUMAN
MINT-7254406   DNLI3_HUMAN
MINT-7254430   RPGF1_HUMAN
MINT-7254454   DLGP4_HUMAN
MINT-7254478   SP1_HUMAN
MINT-7254490   FLNB_HUMAN
MINT-7254502   TGON2_HUMAN
MINT-7254514   C1QR1_HUMAN
MINT-7254526   GHR_HUMAN
MINT-7254538   SHAN2_HUMAN
MINT-7254550   SUV92_HUMAN
MINT-7254562   CELR2_HUMAN
MINT-7254574   ABL2_HUMAN
MINT-7254586   THOC2_HUMAN
MINT-7254634   ASPP2_HUMAN
MINT-7254658   TPX2_HUMAN
MINT-7254694   NFASC_HUMAN
MINT-7254706   STF1_HUMAN
MINT-7254718   FLNC_HUMAN
MINT-7254754   DDX41_HUMAN
MINT-7254766   MLL4_HUMAN
MINT-7254780   TRI39_HUMAN
MINT-7254804   M4K1_HUMAN
MINT-7254852   TAL1_HUMAN
MINT-7254864   ARHGB_HUMAN
MINT-7254876   FLNA_HUMAN
MINT-7254936   KIF22_HUMAN
MINT-7254948   BMX_HUMAN
MINT-7254960   DYN2_HUMAN
MINT-7254999   MY18B_HUMAN
MINT-7255074   RPP38_HUMAN
MINT-7255086   SNX3_HUMAN
MINT-7255245   PRIC3_HUMAN
MINT-7255257   BRD4_HUMAN
MINT-7255293   GCF_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH2 domain binding	plasma membrane, endosome, cytosol, nucleus	actin cytoskeleton organization, regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	74	SSGPRPPVPPSPAQPPPGVSP	-	18669648	HTP	0.51		-	SH2	0.92	-	-
S	83	PSPAQPPPGVSPSRLRIGDQE	-	18669648	HTP	0.29		-	SH2	0.76	-	-
Y	221	QPLGGPEPGPYAQPSVNTPLP	-	12198159	LTP	0.31		CRK SH2	-	0.84	-	-
Y	221	QPLGGPEPGPYAQPSVNTPLP	-	9642287	LTP	0.31		CRK SH2	-	0.84	-	-
Y	221	QPLGGPEPGPYAQPSVNTPLP	-	9480991	LTP	0.31		CRK SH2	-	0.84	-	-
Y	221	QPLGGPEPGPYAQPSVNTPLP	Abl	8194526	LTP	0.31		CRK SH2	-	0.84	-	-