Substrate: Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))
Seq-ID: P46527 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-17680   AKT1_HUMAN
MINT-17889   1433T_HUMAN
MINT-63858   GDIR1_HUMAN
MINT-1779946   MCM7_HUMAN
MINT-3379700   CDK2_HUMAN
MINT-3379718   CDK4_HUMAN
MINT-7219650   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase inhibitor activity,
transforming growth factor beta receptor, cytoplasmic mediator activity,
protein binding		 cytosol,
nucleus		 negative regulation of kinase activity,
regulation of cyclin-dependent protein kinase activity,
negative regulation of cell proliferation,
negative regulation of cell growth,
cell cycle arrest,
G1/S transition of mitotic cell cycle,
autophagic cell death,
cellular response to lithium ion,
induction of apoptosis,
negative regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 10  MSNVRVSNGSPSLERMDARQ - 15302935
HTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ KIS 12093740
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ - 12042314
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ - 15735731
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ - 14504289
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ - 12482975
LTP
0.28
 - -
0.76
 --
S 10  MSNVRVSNGSPSLERMDARQ PKB_group 16780593
LTP
0.28
 - -
0.76
 --
Y 74 FQNHKPLEGKYEWQEVEKGSL SRC 17254967
LTP
1.00
 - CDI
0.62
 --
Y 74 FQNHKPLEGKYEWQEVEKGSL - 18454177
LTP
1.00
 - CDI
0.62
 --
S 83 KYEWQEVEKGSLPEFYYRPPR - 15034923
LTP
0.18
 MOD_CK2_1
 - -
0.59
 1JSU 65.57%
Y 88 EVEKGSLPEFYYRPPRPPKGA - 16195327
LTP
1.00
 - -
0.68
 1JSU 70.31%
Y 88 EVEKGSLPEFYYRPPRPPKGA - 17254966
LTP
1.00
 - -
0.68
 1JSU 70.31%
Y 88 EVEKGSLPEFYYRPPRPPKGA SRC 17254967
LTP
1.00
 - -
0.68
 1JSU 70.31%
Y 89 VEKGSLPEFYYRPPRPPKGAC - 16195327
LTP
0.22
 - -
0.67
 1JSU 36.68%
Y 89 VEKGSLPEFYYRPPRPPKGAC SRC 17254967
LTP
0.22
 - -
0.67
 1JSU 36.68%
S 140 LVDPKTDPSDSQTGLAEQCAG - 17525332
HTP
0.85
 - -
0.82
 --
T 157 QCAGIRKRPATDDSSTQNKRA PKB_group 12244301
LTP
0.94
 MOD_PKB_1
 - -
0.85
 --
T 157 QCAGIRKRPATDDSSTQNKRA PKB_group 12244302
LTP
0.94
 MOD_PKB_1
 - -
0.85
 --
T 157 QCAGIRKRPATDDSSTQNKRA PKB_group 12244303
LTP
0.94
 MOD_PKB_1
 - -
0.85
 --
S 178 NRTEENVSDGSPNAGSVEQTP MAPK1 10831586
LTP
0.15
 MOD_ProDKin_1
 - -
0.94
 --
S 178 NRTEENVSDGSPNAGSVEQTP - 22067460
HTP
0.15
 MOD_ProDKin_1
 - -
0.94
 --
T 187 GSPNAGSVEQTPKKPGLRRRQ - 10831586
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.94
 --
T 187 GSPNAGSVEQTPKKPGLRRRQ CDK2 12700233
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.94
 --
T 187 GSPNAGSVEQTPKKPGLRRRQ - 12042314
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.94
 --
T 187 GSPNAGSVEQTPKKPGLRRRQ - 15735731
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.94
 --
T 198 PKKPGLRRRQT           - 12042314
LTP
0.00
 YWHAQ 14-3-3 -
0.54
 --
T 198 PKKPGLRRRQT           RSK_group 14504289
LTP
0.00
 YWHAQ 14-3-3 -
0.54
 --
T 198 PKKPGLRRRQT           RSK-2 14504289
LTP
0.00
 YWHAQ 14-3-3 -
0.54
 --

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