Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Presenilin 1 (Presenilin 1 (PS-1) (S182 protein))

Seq-ID:

P49768 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-14193   PKP4_HUMAN
MINT-15987   FLNB_HUMAN
MINT-16205   B2CL1_HUMAN
MINT-17726   FLNA_HUMAN
MINT-49819   CADH1_HUMAN
MINT-2837737   GSK3B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium channel activity, beta-catenin binding, endopeptidase activity, PDZ domain binding	centrosome, Golgi membrane, smooth endoplasmic reticulum, integral to plasma membrane, cell surface, kinetochore, nuclear outer membrane, endoplasmic reticulum membrane, rough endoplasmic reticulum, gamma-secretase complex	induction of apoptosis by extracellular signals, membrane protein ectodomain proteolysis, anti-apoptosis, Notch receptor processing, membrane protein intracellular domain proteolysis, Notch signaling pathway, amyloid precursor protein catabolic process, cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	43	RERQEHNDRRSLGHPEPLSNG	-	17081983	HTP	0.72		-	-	0.89	-	medium
S	310	EGDPEAQRRVSKNSKYNAEST	PKA_group	14576165	LTP	0.25	MOD_PKA_1	-	PSN	0.66	-	medium
S	346	FSEEWEAQRDSHLGPHRSTPE	PKC_alpha	14576165	LTP	0.24		-	PSN	0.62	-	medium
S	353	QRDSHLGPHRSTPESRAAVQE	GSK-3_beta	11104755	LTP	0.15	MOD_GSK3_1	-	PSN	0.59	-	medium
T	354	RDSHLGPHRSTPESRAAVQEL	CDK_group	12056836	LTP	0.11		-	PSN	0.58	-	medium
T	354	RDSHLGPHRSTPESRAAVQEL	CDK5	12056836	LTP	0.11		-	PSN	0.58	-	medium
S	357	HLGPHRSTPESRAAVQELSSS	GSK-3_beta	11104755	LTP	0.93	MOD_GSK3_1	-	PSN	0.48	-	medium
S	365	PESRAAVQELSSSILAGEDPE	-	18669648	HTP	0.33		-	PSN	0.47	-	medium
S	366	ESRAAVQELSSSILAGEDPEE	-	18669648	HTP	0.90		-	PSN	0.46	-	medium
S	367	SRAAVQELSSSILAGEDPEER	-	17081983	HTP	0.50		-	PSN	0.44	-	medium
S	367	SRAAVQELSSSILAGEDPEER	-	18669648	HTP	0.50		-	PSN	0.44	-	medium