Substrate: DNA ligase IV (DNA ligase IV)
Seq-ID: P49917 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
protein C-terminus binding,
metal ion binding,
ATP binding,
DNA ligase (ATP) activity		 condensed chromosome,
DNA-dependent protein kinase-DNA ligase 4 complex,
DNA ligase IV complex		 chromosome organization,
central nervous system development,
cell division,
positive regulation of neurogenesis,
isotype switching,
DNA ligation involved in DNA recombination,
cell cycle,
T cell receptor V(D)J recombination,
in utero embryonic development,
response to gamma radiation,
response to X-ray,
nucleotide-excision repair, DNA gap filling,
neuron apoptosis,
initiation of viral infection,
negative regulation of neuron apoptosis,
somatic stem cell maintenance,
DNA replication,
T cell differentiation in the thymus,
single strand break repair,
DNA ligation involved in DNA repair,
cell proliferation,
double-strand break repair via nonhomologous end joining,
positive regulation of fibroblast proliferation,
pro-B cell differentiation,
provirus integration
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 199 MIIKDLKLGVSQQTIFSVFHN ATM 10608806
LTP
1.00
 MOD_PIKK_1
 - DNA_ligase_A_N
0.07
 --
T 650 IIEHLKAPNLTNVNKISNIFE DNA-PK 15194694
LTP
0.00
 - -
0.23
 --

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