Substrate: Polo-like kinase 1 (Serine/threonine kinase)
Seq-ID: P53350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16690   MPIP3_HUMAN
MINT-63234   RECQ5_HUMAN
MINT-2634770   RGRF1_HUMAN
MINT-7266250   P53_HUMAN
MINT-7266318   MDM2_MOUSE
MINT-7266353   MDM2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding,
ATP binding,
polo kinase kinase activity,
anaphase-promoting complex binding		 centrosome,
cytosol,
outer kinetochore of condensed nuclear chromosome,
nucleoplasm		 protein amino acid phosphorylation,
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
G2/M transition DNA damage checkpoint,
positive regulation of proteasomal ubiquitin-dependent protein catabolic process,
regulation of mitotic cell cycle,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 137 FVVLELCRRRSLLELHKRRKA - 15713655
LTP
1.00
 - S_TKc
0.08
 2RKU 4.10%
T 210 KVEYDGERKKTLCGTPNYIAP LOK 12207013
LTP
1.00
 - S_TKc
0.27
 2RKU 68.12%
T 210 KVEYDGERKKTLCGTPNYIAP - 18669648
HTP
1.00
 - S_TKc
0.27
 2RKU 68.12%
T 214 DGERKKTLCGTPNYIAPEVLS - 18669648
HTP
1.00
 - S_TKc
0.28
 2RKU 67.12%
S 387 MLQQLHSVNASKPSERGLVRQ - 18669648
HTP
0.62
 - -
0.49
 1UMW 22.95%

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