Substrate: Histone deacetylase 4 (Enzyme: Deacetylase)
Seq-ID: P56524 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49703   MEF2A_HUMAN
MINT-49706   MEF2C_HUMAN
MINT-3296491   1433Z_HUMAN
MINT-3975818   1433S_HUMAN
MINT-6802058   HIF1A_HUMAN
MINT-7144512   ZN148_HUMAN
MINT-7299965   BUB1B_HUMAN
MINT-7555703   ATF2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium ion binding,
transcription repressor binding,
specific transcriptional repressor activity,
transcription activator binding,
transcription activator activity,
histone deacetylase activity,
histone deacetylase binding,
zinc ion binding		 histone deacetylase complex,
transcriptional repressor complex		 B cell differentiation,
negative regulation of gene-specific transcription from RNA polymerase II promoter,
nervous system development,
positive regulation of cell proliferation,
negative regulation of transcription factor activity,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of myotube differentiation,
transcription,
histone H4 deacetylation,
positive regulation of transcription factor activity,
response to denervation involved in regulation of muscle adaptation,
inflammatory response,
histone H3 deacetylation,
response to interleukin-1,
chromatin remodeling,
cardiac muscle hypertrophy in response to stress,
negative regulation of glycolysis,
positive regulation of protein sumoylation,
peptidyl-lysine deacetylation,
regulation of protein binding
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 246 KDDFPLRKTASEPNLKLRSRL - 10958686
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.64
 - low
S 246 KDDFPLRKTASEPNLKLRSRL - 10869435
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.64
 - low
S 467 RQHRPLGRTQSAPLPQNAQAL CaM-KIV 11470791
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.84
 - low
S 467 RQHRPLGRTQSAPLPQNAQAL - 18669648
HTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.84
 - low
S 565 GVQVKQEPIESDEEEAEPPRE - 18669648
HTP
0.37
 - -
0.90
 - low
S 632 GGHRPLSRAQSSPASATFPVS CaM-KIV 11470791
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.67
 - low
S 632 GGHRPLSRAQSSPASATFPVS - 18669648
HTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.67
 - low
S 633 GHRPLSRAQSSPASATFPVSV - 18669648
HTP
1.00
 - -
0.68
 - low
S 636 PLSRAQSSPASATFPVSVQEP - 18669648
HTP
1.00
 - -
0.73
 - low
T 638 SRAQSSPASATFPVSVQEPPT - 18669648
HTP
0.10
 - -
0.76
 - low

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