Substrate: ADAM 17 (Metallo protease)
Seq-ID: P78536 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13999   MD2L1_HUMAN
MINT-58311   PTN3_HUMAN
MINT-1901801   DLG1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
interleukin-6 receptor binding,
metalloendopeptidase activity,
zinc ion binding,
integrin binding,
PDZ domain binding,
SH3 domain binding		 integral to plasma membrane,
cell surface,
actin cytoskeleton,
apical plasma membrane,
membrane raft		 positive regulation of cell growth,
response to hypoxia,
response to high density lipoprotein stimulus,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
PMA-inducible membrane protein ectodomain proteolysis,
response to drug,
regulation of mast cell apoptosis,
membrane protein intracellular domain proteolysis,
positive regulation of epidermal growth factor receptor activity,
epidermal growth factor receptor signaling pathway,
positive regulation of T cell chemotaxis,
germinal center formation,
Notch signaling pathway,
positive regulation of transforming growth factor beta receptor signaling pathway,
cell adhesion mediated by integrin,
response to lipopolysaccharide,
T cell differentiation in the thymus,
spleen development,
positive regulation of chemokine production,
neutrophil mediated immunity,
B cell differentiation,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
wound healing, spreading of epidermal cells,
negative regulation of interleukin-8 production
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 379 YYSPVGKKNIYLNSGLTSTKN - 17081983
HTP
1.00
 - Reprolysin
0.31
 2DDF 25.76%
S 382 PVGKKNIYLNSGLTSTKNYGK - 17081983
HTP
0.24
 - Reprolysin
0.31
 2DDF 0.00%
T 735 RIIKPFPAPQTPGRLQPAPVI MAPK3 12058067
LTP
0.12
 MOD_ProDKin_1
 - -
0.53
 --
S 791 PFPNSSTAAKSFEDLTDHPVT - 12621058
LTP
1.00
 - -
0.73
 --
S 791 PFPNSSTAAKSFEDLTDHPVT - 17081983
HTP
1.00
 - -
0.73
 --
S 791 PFPNSSTAAKSFEDLTDHPVT - 18669648
HTP
1.00
 - -
0.73
 --
S 819 FKLQRQNRVDSKETEC      - 12621058
LTP
1.00
 - -
0.72
 --

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