Substrate: Mdm2 (Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2. -) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2))
Seq-ID: Q00987 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16320   ARRB2_HUMAN
MINT-58469   MED1_HUMAN
MINT-58599   CHK2_HUMAN
MINT-68739   HIPK2_HUMAN
MINT-1776635   RB_HUMAN
MINT-3376147   ARBK1_HUMAN
MINT-3391121   RL5_HUMAN
MINT-4793330   PML_HUMAN
MINT-6540837   PSME3_HUMAN
MINT-6540889   P53_HUMAN
MINT-6801697   DAXX_HUMAN
MINT-6823537   AKT1_HUMAN
MINT-6823574   PIM2_HUMAN
MINT-6823669   FKBP3_HUMAN
MINT-7013760   RYBP_HUMAN
MINT-7266353   PLK1_HUMAN
MINT-7718939   SNAI1_HUMAN
MINT-7904837   GORAB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
p53 binding,
enzyme binding,
zinc ion binding,
basal transcription repressor activity,
ubiquitin-protein ligase activity		 plasma membrane,
endocytic vesicle membrane,
cytosol,
nucleolus,
nucleoplasm,
insoluble fraction,
protein complex		 positive regulation of cell proliferation,
protein complex assembly,
protein destabilization,
positive regulation of mitotic cell cycle,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
positive regulation of proteasomal ubiquitin-dependent protein catabolic process,
protein ubiquitination involved in ubiquitin-dependent protein catabolic process,
interspecies interaction between organisms,
negative regulation of cell cycle arrest,
negative regulation of transcription from RNA polymerase II promoter,
protein localization in nucleus,
establishment of protein localization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 157 PSSSHLVSRPSTSSRRRAISE - 15688025
LTP
1.00
 - -
0.65
 - medium
S 166 PSTSSRRRAISETEENSDELS PKB_group 11504915
LTP
0.09
 MOD_PKB_1
 - -
0.78
 - medium
S 166 PSTSSRRRAISETEENSDELS DAPK3 15001356
LTP
0.09
 MOD_PKB_1
 - -
0.78
 - medium
S 186 SGERQRKRHKSDSISLSFDES PKB_group 11504915
LTP
0.97
 MOD_PKB_1
 - -
0.53
 - medium
S 188 ERQRKRHKSDSISLSFDESLA PKB_group 15169778
LTP
1.00
 MOD_PKB_1
 - -
0.46
 - medium
S 188 ERQRKRHKSDSISLSFDESLA PKB_group 15527798
LTP
1.00
 MOD_PKB_1
 - -
0.46
 - medium
S 240 EHSGDWLDQDSVSDQFSVEFE - 12167711
LTP
1.00
 - -
0.49
 - medium
S 242 SGDWLDQDSVSDQFSVEFEVE - 12167711
LTP
1.00
 - -
0.47
 - medium
S 246 LDQDSVSDQFSVEFEVESLDS - 12167711
LTP
1.00
 - -
0.50
 - medium
S 260 EVESLDSEDYSLSEEGQELSD - 12167711
LTP
1.00
 - -
0.69
 - medium
S 262 ESLDSEDYSLSEEGQELSDED - 12167711
LTP
0.13
 - -
0.74
 - medium
S 269 YSLSEEGQELSDEDDEVYQVT - 15703839
LTP
0.13
 - -
0.66
 - medium
Y 394 QASQSQESEDYSQPSTSSSII Abl 14757045
LTP
0.09
 - -
0.64
 - medium
Y 394 QASQSQESEDYSQPSTSSSII Abl 12110584
LTP
0.09
 - -
0.64
 - medium
Y 394 QASQSQESEDYSQPSTSSSII Abl 16702947
LTP
0.09
 - -
0.64
 - medium
S 395 ASQSQESEDYSQPSTSSSIIY ATM 11331603
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 - medium
S 407 PSTSSSIIYSSQEDVKEFERE ATR 14654783
LTP
1.00
 MOD_PIKK_1
 - -
0.53
 - medium

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