Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

TIE2 (TEK) (PTK receptor for angiopoietin 1)

Seq-ID:

Q02763 [Homo sapiens]

Download:

Interaction Network(s):

NetworKIN

External Source(s):

Phosida

MINT Interaction(s):

-

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transmembrane receptor protein tyrosine kinase activity, ATP binding, protein binding	basolateral plasma membrane, integral to plasma membrane, cell surface, microvillus, apical plasma membrane, membrane raft	positive regulation of ERK1 and ERK2 cascade, protein amino acid phosphorylation, protein oligomerization, cell-cell signaling, positive regulation of protein kinase B signaling cascade, regulation of cell proliferation, transmembrane receptor protein tyrosine kinase signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	897	NLLGACEHRGYLYLAIEYAPH	-	11080633	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	TyrKc	0.05	1FVR	36.24%
Y	897	NLLGACEHRGYLYLAIEYAPH	-	11513602	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	TyrKc	0.05	1FVR	36.24%
Y	992	DFGLSRGQEVYVKKTMGRLPV	TIE2	11513602	LTP	1.00		-	TyrKc	0.13	1FVR	62.01%
Y	992	DFGLSRGQEVYVKKTMGRLPV	-	8382358	LTP	1.00		-	TyrKc	0.13	1FVR	62.01%
Y	1048	PYCGMTCAELYEKLPQGYRLE	-	11080633	LTP	1.00		-	TyrKc	0.12	1FVR	39.30%
Y	1048	PYCGMTCAELYEKLPQGYRLE	TIE2	11513602	LTP	1.00		-	TyrKc	0.12	1FVR	39.30%
Y	1102	LNRMLEERKTYVNTTLYEKFT	-	10521483	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1102	LNRMLEERKTYVNTTLYEKFT	-	9632797	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1102	LNRMLEERKTYVNTTLYEKFT	TIE2	12082108	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1108	ERKTYVNTTLYEKFTYAGIDC	TIE2	10521483	LTP	0.08		DOK_group PTB; GRB14 SH2; PIK3R1 SH2	-	0.11	1FVR	76.42%
Y	1108	ERKTYVNTTLYEKFTYAGIDC	TIE2	12665569	LTP	0.08		DOK_group PTB; GRB14 SH2; PIK3R1 SH2	-	0.11	1FVR	76.42%
Y	1113	VNTTLYEKFTYAGIDCSAEEA	TIE2	10521483	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.12	1FVR	15.72%
Y	1113	VNTTLYEKFTYAGIDCSAEEA	-	12665569	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.12	1FVR	15.72%